Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Genetically identical"”.
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Embryogenic response of potato anther culture to colchicine
… x ID 5 family, from the second experiment, were genetically characterized based on RAPD markers. Forty-three loci were scored from 13 primers for groups of monoploids derived from the same flasks of anther culture. From one flask, two pairs of monoploids were found to be genetically identical. …
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Origins of cell-to-cell variability in apoptosis
… genetic differences. However, even members of a genetically identical group of cells or organisms in identical environments can exhibit variability in state and phenotype. One striking example of such heterogeneity is revealed when a genetically identical population of human cells is exposed to …
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The Discordant Development of Sexual Orientation in Identical Twins
The present thesis investigated how genetically identical twins with discordant sexual orientations differed in correlates of their sexual orientation in order to understand to what degree non-genetic factors affect the formation of sexual orientation. Because identical twins share 100% of their …
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Identification and characterisation of murine metastable epialleles conferred by endogenous retroviruses
… transgenerational epigenetic inheritance within genetically identical individuals. It is not known whether the behaviour exhibited by the ERV at Avy represents a common occurrence throughout the genome or is unusual. Taking a genetic approach in purified cell populations, I have conducted a …
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Multiplexed biochemical imaging reveals the extent and complexity of non-genetic heterogeneity in DNA damage-induced caspase dynamics.
Genetically identical cells show a heterogeneous response to a multitude of signals such as growth factors and DNA damage. While this heterogeneity has been shown to be a major determinant of treatment success in several diseases including cancer, little is known about how differences in …
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Integrating discrete stochastic models with single-cell and single-molecule experiments
… have noticed that individual cells that are genetically identical behave seemingly randomly in the way they carry out their most basic functions. The field of stochastic single-cell biology has been focused developing mathematical and computational tools to understand how cells try to buffer …
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Determining the Fate of Hybridized Genomes in the Allopolyploid Brassica napus
… S12 generations. Although these lineages were genetically identical at the time of hybridization, divergence was apparent by the S2 generation. There was a significant increase in sequence loss across generations within both lineages. Four of six generations from both lineages displayed no …
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Regulation of DNA replication and cellular responses to perturbations in replication in the bacterium Bacillus subtilis
When a cell grows and divides to give rise to genetically identical cells, the genome of the cell is duplicated prior to cell-division. The process of genomic duplication is called DNA replication, and is closely coordinated with other processes in the cell, such as growth rate, and cell division. …
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Stochastic Modeling of Gene Expression and Post-transcriptional Regulation
… that can give rise to phenotypic differences for genetically identical cells. Understanding how the underlying biochemical reactions give rise to variations in mRNA/protein levels is thus of fundamental importance to diverse cellular processes. Recent technological developments have enabled …
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Dissecting Tumor Heterogeneity In Lung Cancer
… cancer is a heterogeneous disease composed of genetically and phenotypically distinct tumor cells as well as a heterogeneous microenvironment consisting of non-cancer cells and extracellular matrix. Constant interactions among these components ultimately leads to a complex tumor tissue that is …
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Several consequences of aneuploidy
… of euploid and trisomic cell lines that were genetically-identical and differed only in karyotype. I discovered that under most circumstances, aneuploidy impeded proliferation, anchorage-independent growth, and tumor formation in xenografts. Thus, single-chromosome aneuploidy actually …
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Factors affecting VA-mycorrhizal community structure in the Namib Dune Field: and the population biology of an ectomycorrhizal Basidiomycete: Suillus granulatus
… compatible individuals were not necessarily genetically identical. I concluded that RAPD marker analysis provides a more effective means for determining clonal distribution in ectomycorrhizal populations, than does somatic incompatibility testing.
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Derepression of heterochromatin inactivation by induction of a nearby promoter in Drosophila melanogaster
… initiating a heat shock response, but otherwise genetically identical. These lines were reared in both heat shock and non-heat shock conditions and then variegation was assessed by the amount of eye pigment deposited by the derepression of the mini-white gene. Our results indicate that …
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Determining The Genotype-Phenotype Connection In Synthetic Inducible Gene Expression Systems
… an individual cell’s phenotype. However, even genetically identical cells display a variety of phenotypes, which may be attributed to differences in their environment. Yet, even after controlling for these two factors, individual phenotypes still diverge due to noisy gene expression. Synthetic …
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Highly Constrained Kinetic Models for Quantitative Single-Cell Gene Expression Analysis
Cells are for the most part genetically identical, and it is the gene expression which determines different cell types in the body. Transcription, the first step in gene expression, is a complex, multi-step process initiated by transcription factors (TFs) binding to DNA promoter regions, followed …
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Predation Risk and Colony Structure in the Pea Aphid, Acyrthosiphon Pisum
… aggregations, that is, when individuals are genetically identical (the "evolutionary self"). As aphids (small, herbivorous insects) are parthenogenetic, emit alarm signals, and have high levels of phenotypic plasticity to cope with environmental stressors like predation risk, they are a model …
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Monoallelic Gene Expression In Human Neural Stem Cells
… potential source of phenotypic diversity between genetically identical neural stem cells in vitro. Furthermore, I find the novel RME genes reported in this thesis to be epigenetically distinct from biallelic genes in human foetal and adult brain in a manner consistent with monoallelic expression. …
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Gene expression changes during mammalian male meiotic initiation
… mitosis, which generates daughter cells that are genetically identical to the mother cell, or meiosis, which divides the genome for haploid gamete generation. Germ cells undergo meiotic initiation, the transition from the mitotic cell cycle to the meiotic cell cycle, once in a generation. In …
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Human Cellular Genetics of Innate Immunity
… alongside cell-to-cell heterogeneity in a genetically identical cell population, the basis of this variation is not fully understood. In this PhD, I established large-scale single-cell RNA sequencing experiments to study cellular variation in the innate immune response in fibroblasts of 70 …
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Geobiology of marine magnetotactic bacteria
… FISH also showed that aggregates consist of genetically identical cells. QPCR data indicated that populations are finely layered around the oxic-anoxic interface: cocci immediately above the dissolved Fe(II) peak, barbells immediately below, the MMP in microsulfidic waters, and the …
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