Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Genetic transcription"”.
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Regulatory Control of Brucella Genetic Transcription
… this thesis probes multiple aspects of Brucella transcriptional regulation. Chapter 1 analyzes historical and current justifying the importance of the work to the Brucella field. Chapter 2 uses a mouse model of infection along with transcriptomics and traditional bacteriological assays to …
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Protein localization during the cyanobacterial circadian cycle
… shown that the circadian clock is independent of genetic transcription and depends only upon the interactions between three proteins - KaiA, KaiB, and KaiC. As such, the cyanobacterial circadian clock provides a unique opportunity to study complex dynamics that can result just from the …
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Synthesis and biological research of the pseudomonas aeruginosa signaling compounds PQS and N-3-oxo-dodecanoyl-L-homoserine lactone
… fibrosis type infection, where the change in genetic transcription could be easily determined. The presence of cytokines produced during Pseudomonas aeruginosa infections was established based upon reverse transcriptase PCR followed by the amplification of cytokine cDNA and analysis by gel …
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Development and Characterization of a Stopped-Flow-Bypass Analysis System With Applications To Biochemical Measurements
… (Kms, Kis, VMAXs) were determined directly. Genetic transcription levels of luciferase in whole intact E. coli cells were also determined using chemiluminescent detection. Flow system configuration, components, and flow ratios were investigated for their effects on achieving physical steady …
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Spatiotemporal Regulation of the NADP(H) Phosphatase Nocturnin
… clock" is a molecular oscillator driven by a genetic transcription/translation feedback loop, which orchestrates the rhythmic expression of thousands of genes. An intimate link between circadian clocks and metabolism is established by the rhythmic transcription of output genes involved in …
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Dissecting Transcriptional Regulatory Networks with Systems Biology Approaches
… is focused on understanding these mechanisms of transcriptional regulation using systems biology approaches. Transcription regulatory networks play an important role in mediating external stimuli and coordinating responses to changing environments. Different methods that infer regulatory …
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The characterization of the ABF-1 promoter
<p>The basic helix-loop-helix (bHLH) family oftranscription factors consists of proteins involved in cellular proliferation and differentiation. The HLH structure plays a key role in protein-protein dimerization and with the DNA target sites, referred to as E boxes containing the consensus DNA …
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Isolation and characterization of CEABF-1, the ABF-1 homolog in C. elegans
<p>The basic helix-loop-helix (bHbH) family-of transcription factors is important in many developmental and regulatory pathways such as cellular proliferation and differentiation, lineage commitment, sex determination, neurogenesis, myogenesis, hematopoeisis and pancreatic development. The …
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Mapping of the repression domain and the subcellular localization of the ABF-1 protein
<p>Basic helix-loop-helix transcription factors play important roles in pathways that result in the formation of such tissues as skeletal muscle, the nervous system, pancreas and heart. A recently discovered B-cell restricted bHLH transcription factor activated Bcell factor 1 (ABF -1) is suspected …
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Regulatory RNAs at the Heart of Sugar Metabolism: New Mechanisms and Novel Discoveries
Bacteria are adept at using a variety of posttranscriptional strategies to regulate gene expression. Specifically, various RNA-mediated genetic control elements have been discovered in the past decade through a combination of genetics, bioinformatics, and transcriptomic approaches. Together, these …
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Characterization of downstream target genes regulated by ABF-1 in different states of B cell development
… belongs to the basic helix-loop-helix family of transcription factors. ABF-1 mRNA molecules have been detected in the lymphoid tissues, which include the bone marrow, lymph nodes, and appendix, as well as transformed B cells lines infected with Epstein-Barr virus. This study investigates the role …
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The quorum-sensing regulation of Vibrio fischeri : novel components of the autoinducer/LuxR regulatory circuit
… 30C6-HSL and the ainS-dependent C8-HSL) and the transcriptional activator LuxR regulate the luminescence system in a cell-density dependent manner by a process termed quorum sensing. In this study, five additional proteins whose production is regulated by quorum sensing are described, and the …
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Characterization of the 5̕ untranslated region ( 5̕ UTR) of the alcohol oxidase I (AOX I) gene in Pichia pastoris.
… were due to translation rates and not nRNA transcription or degradation.</p>
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Characterization of ABF-1 in C. elegans and regulation of cellular growth and ID3 by human ABF-1
<p>ABF -1 is a human class II bHLH transcription factor that is expressed predominantly in activated B cells and EBV immortalized cell lines. A portion of this study sought to characterize the homolog of ABF- l in Caenorhabditis e/egans. The nematode gene product, ceABF -1, is capable of forming …
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Characterization of the Pichia pastoris alcohol oxidase I promoter
… the last 15 years, little is known about the transcription controls at a molecular level. A 5'>3' deletion analysis of the AOXI promoter was perrormed to gain understanding of the promoter's regulation and provided insight to the approximate locations of the important regulatory regions. A …
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