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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 146 for “"Genetic screen"”.

  1. A FORWARD CHEMICAL GENETIC SCREEN FOR NOVEL TARGET DISCOVERY IN PLANTS

    KOH SALLY SHUXIAN2025

    nus

  2. A forward genetic screen to identify factors that control meiotic recombination in Arabidopsis thaliana

    Coimbatore Nageswaran, DivyashreeUniversity of Cambridge2019

    Meiotic recombination promotes genetic variation by reciprocal exchange of genetic material producing novel allelic combinations that influence important agronomic traits in crop plants. Therefore, harnessing meiotic recombination has the potential to accelerate crop improvement via classical …

    cambridge Repository record

  3. A genetic screen for genes involved in dendrite morphogenesis of central neurons in Drosophila melanogaster

    North, AnnemarieOxford Brookes University2011

    … morphogenesis, a mosaic loss of function screen was developed and carried out in Drosophila melanogaster for chromosomal regions required for motor neuron dendrite development. Specifically, the Mosaic Analysis with a Repressible Cell Marker (MARCM) method was modified so that individual …

    oxford-brookes Repository record

  4. A Genetic Screen for Tribbles Suppressors Identifies the E3 Ubiquitin Ligase Neuralized as a Novel Target

    Shipman, Anna LynnUniversity of Missouri -- Kansas City2017

    … used the Drosophila wing as a model tissue for a genetic screen to identify novel targets of Tribbles. Drosophila Tribbles is the founding member of a family of pseudokinases conserved between metazoans. Tribbles family proteins have roles in the cell cycle, insulin signaling, tissue growth and …

    umkc Repository record

  5. A genetic screen to identify novel Helicobacter pylori virulence factors using Saccharomyces cerevisiae as a model eukaryotic cell

    Bothwell, Amelia M.

    … disease due to environmental factors, host genetic factors, and more significantly, genetic differences in the infecting H pylori strains. Type I strains of H pylori contain a 40-kb cytotoxin-associated pathogenicity island (cag PAl) that encodes and secretes the CagA protein into host …

    eastern-wash Repository record

  6. An Integrated Software System for EEG/EMG-Based Forward Genetic Screen of Sleep/Wake Abnormalities in ENU-Mutagenized Mice

    Sato, Makito2016

    … but highly interesting question through forward genetics in mice. We have initiated a dominant screen of ENU-mutagenized mice, in which a comprehensive set of sleep parameters is measured via EEG/EMG-based somnography analysis in basal light/dark periods as well as in the recovery period …

    utswmed Repository record

  7. A Forward Genetic Screen Revealed the Role of POLDIP2 in Ensuring Maternal Inheritance of Mitochondrial DNA in Drosophila melanogaster

    Wang, ZimingUniversity of Cambridge2024

    … homeostasis and apoptosis. They house their own genetic materials known as mitochondrial DNA (mtDNA). In most animals, the inheritance of mtDNA follows a uniparental pattern, generally from the maternal side. Maternal inheritance is accomplished by mechanisms actively degrading paternal mtDNA …

    cambridge Repository record

  8. Cell Death Mechanisms in Drosophila Differentiated Photoreceptor Neurons

    Gambis, Alexis Robert

    … in vivo. These tools enable a recessive genetic screen to search for genes required for the survival of differentiated photoreceptors. Many redox and mitochondrial genes were found to protect photoreceptors from late cell death. Here, we focus on the iron-storage complex, Ferritin. …

    rockefeller Repository record

  9. Isolation and characterization of Saccharomyces cerevisiae mutants for vacuolar import and autophagocytosis

    Andrei, Luminita Cornelia2012

    … shows enzymatic activity. We developed a new genetic screen to isolate mutants in the biogenesis of the vacuolar aminopeptidase 1 based on the enzymatic activity. We developed a new genetic screen to isolate mutants in the biogenesis of the vacuolar aminopeptidase 1 based on the enzymatic …

    goettingen Repository record

  10. The rhinoceros gene of drosophila restricts cell fate specification in the developing eye

    Voas, Matthew G. (Matthew Gary), 1973-Massachusetts Institute of Technology2003

    … Yan, thus allowing differentiation. A previous genetic screen identified modifiers of YanACT, a constitutively active isoform of Yan. From this screen, two alleles of Enhancer of YanAC, 3-5 (EY3-5) were identified as enhancers. A genetic screen was conducted to isolate new EY3-5 alleles for …

    mit Repository record

  11. Identification of a novel role for Eb1 in the regulation of cell growth and G1-S phase progression in Drosophila / by Deborah Coates.

    Coates, Deborah Patricia2003

    … Eb1, dEb1, which was identified in a cyclin E genetic screen. A dominant modifier screen was undertaken to identify novel regulators of cyclin E, and cell cycle progression using a hypomorphic allele of cyclin E. One suppressor from this screen, Su(DmcycEjp)2.5, was identified as a potential …

    adelaide Repository record

  12. N-Glycosylation Protects Host from Mycobacterial Infection

    Lyu, BingnanUniversity of Cambridge2024

    … their growth. Through a zebrafish forward genetic screen, we have identified the early steps of N-glycosylation are required for the macrophage to resist mycobacterial infections. N-glycosylation attaches an oligosaccharide molecule to nascent secretory or membrane proteins within the …

    cambridge Repository record

  13. The Characterization of Nemadipine and Migrazole as Small Molecule Tools for Use in the Nematode Caenorhabditis elegans

    Kwok, Trevor2012

    … investigation. They provide an alternative to genetic perturbation and may offer more control over a target’s activity. C. elegans has recently gained prominence as a platform to discover new chemical tools. Through large-scale screens for compounds that induce phenotypes consistent with the …

    toronto-retro Repository record

  14. Forward screening for herbicide resistance in Arabidopsis thaliana and the monocot species Triticum aestivum

    Reavell-Roy, ElysabethUniversity of Ontario Institute of Technology2019

    … mutants were identified from previous forward genetic screens. Some identified CBI resistant mutants demonstrated altered cellulose crystallinity, and cell wall saccharification. In a larger crop species, these characteristics would allow for plant cell wall material to be efficiently converted …

    uoit Repository record

  15. Mosaic Analysis of Neurogenesis and Neuronal Morphogenesis in Drosophila Learning and Memory Center Mushroom Bodies

    Zhu, SijunUniversity of Illinois at Urbana-Champaign2015

    Based on the above findings, a forward genetic screen using MARCM (m&barbelow;osaic a&barbelow;nalysis with r&barbelow;epressible c&barbelow;ell m&barbelow;arker) system, which uniquely labels wild type or homozygous mutant single-cell or subcell lineages born at specific developmental stages, was …

    uiuc Repository record

  16. Using Synthetic Gene Clusters to Model Resistance Gene Evolution by Meiotic Recombination in Arabidopsis thaliana

    Simon, Stacey AnnVirginia Tech2007

    … of this dissertation were to develop a genetic screen that models meiotic unequal crossing over at a synthetic RPP8 (synthRPP8) resistance gene cluster and to assess the effect of abiotic stress on recombination with the synthetic RBCSB gene cluster (synthRBCSB) in Arabidopsis. The …

    vt Repository record

  17. Factors and mechanisms of archaeal transcription termination and DNA repair

    Marshall, Craig, author, Santangelo, Thomas J., advisor, Peersen, Olve, committee member, Wilusz, Carol, committee member, Yao, Tingting, committee memberColorado State University. Libraries2022

    … elongation complexes (TECs) in Archaea from the genetically tractable Thermococcus kodakarensis, and use both factors as models to explore the molecular mechanisms involved in collapse of the TEC. The Factor that terminates transcription in Archaea (FttA), a close homolog of the human CPSF …

    colostate Repository record

  18. Molecular Interactions between Apicomplexan Parasites and their Host Cells

    Toro Moreno, Maria2021

    … Plasmodium liver stage, we implemented a forward genetic screen to identify host factors within the human druggable genome that are critical to P. berghei infection in hepatoma cells, as well as RNA-seq approaches to delineate host and Plasmodium gene expression regulation during infection. …

    duke Repository record

  19. Characterisation of Mitochondrial Dynamics and Mitochondrial DNA Inheritance in Drosophila melanogaster

    Li, Andy Yu ZhiUniversity of Cambridge2023

    … bodies, and the fusome. Next, I used a reverse genetic screen to identify genes linked to mitochondrial trafficking along microtubules that were required for mitoball assembly: <i>milton</i>, <i>miro</i>, and <i>khc</i>. I also generated an X0 male and found that the loss of the Y chromosome did …

    cambridge Repository record

  20. Zebrafish Mutagenesis Study of Host Determinants of Mycobacterial Infection Outcome

    Televantos, ConstantinosUniversity of Cambridge2020

    This thesis describes a large-scale forward genetic screen in zebrafish for host determinants of mycobacterial infection outcome that I participated in. Zebrafish larvae from families randomly mutagenized with N-ethyl-N-nitrosourea were infected with Mycobacterium marinum and monitored over time. …

    cambridge Repository record

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