Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 73 for “"Genetic regulation"”.
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Genetic Regulation of Müllerian Duct Regression
<p>Mammals, including humans, develop progenitor tissues for both male and female reproductive tract organs before they fully differentiate into a male or female tract. The progenitor tissue for the male reproductive tract is known as the Wolffian duct (WD), and the progenitor tissue for the female …
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Tissue specific genetic regulation of Interleukin 6
Interleukin 6 (IL6) is associated with arterial disease development, progression and surgical outcome. Raised levels of IL6 may play a causal role in disease development or may be the effect of pathology. An IL6 single nucleotide polymorphism (SNP) G- 174C has been identified and reported to …
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Linking genetic regulation and the metabolic state
Genome sequencing and the subsequent development of high-throughput probing of cellular states have dramatically increased our ability to understand cellular compensation to perturbation. As such, integrating system-wide measurements (e.g. gene expression) with networks of protein-protein …
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Genetic regulation of cell extrusion in caenorhabditis elegans
Programmed elimination of cells occurs during animal development and homeostasis to maintain appropriate cell numbers. One evolutionarily conserved method by which organisms eliminate cells in a programmed manner is by cell-autonomous activation of the caspase-mediated apoptosis pathway, which …
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Genetic Regulation of Intrinsic Endurance Exercise Capacity in Mice
… family studies. This variation is evidence of a genetic component to the phenotype of endurance exercise capacity: however, the genetic factors responsible for explaining this variation are undefined, in part because previous research has been performed on a limited scale. Therefore, three sets …
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Genetic Regulation of Maize and Sorghum under Abiotic Stress
… resilience in agronomic crops and understand the genetic mechanisms conferring adaptation to water-limited environments.
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Genetic regulation of dietary restriction-induced longevity in Caenorhabditis elegans
… stroke in humans. Clearly, identification of the genetic mechanisms underlying these protective effects of DR would have profound implications for the development of novel medical interventions affecting diseases of aging. Recent studies of model organisms have revealed many genetic pathways that …
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Genetic Regulation of Retinal Cells by Variation of Underlying Elastic Modulus
… This finding implies an alteration of the genetic regulation arising from the tension in the cytoskeleton. Hence, a structure that does not exist inside the nucleus is changing the transcription of DNA. How this non-chemical signaling occurs, as well as which genes are affected in which …
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Clonal architecture and genetic regulation of the developing mammalian cerebral cortex
… of neurons and glia that differentiate into genetically-defined subtypes residing in different regions of the brain with different mature functions. While development is ongoing, it is challenging to study individual cells as they divide, differentiate, and migrate through the growing layers …
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Genetic regulation of maize floral development - insights from the transcriptome and translatome
… gene expression. Understanding gene expression regulation in maize floral development is critical to regulate floret fertility in other grasses and potentially useful to engineer more productive cereal crops. In this work, I focus on gene expression regulation at transcriptome and translatome …
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Modeling Time-Varying Networks with Applications to Neural Flow and Genetic Regulation
… as neural growth during learning or changes in genetic regulation during cell differentiation. Approaches are needed that explicitly model networks as they change in time and that characterize the nature of those changes.</p><p>In this work, we develop a new class of graphical models in which …
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Gillenia trifoliata: a tool to understand the genetic regulation of apple flesh development
… The aim of this thesis was to understand the genetic regulation of apple flesh development using Gillenia as a negative control. Firstly, phenological and genomic resources were established for Gillenia (Ireland, Wu, et al., 2021), and together provide an interspecies standardisation tool and …
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Genetic regulation of neuronal stem cell differentiation: a single-cell sequencing study in planarians
… adult stem cells: the neoblasts. However, the genetic networks that drive the differentiation of planarian adult stem cells into the neural lineage are still unknown. Here we show that single-cell expression profiling technologies allow disentangling neuronal heterogeneity to investigate the …
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Uncovering the Importance of Cell Morphology, Genetic Regulation, and Neuronal Signalling in Quiescent Neural Stem Cells
… The thesis aimed to understand NSCs and their regulation using three separate methods. Firstly, an investigation was performed into how the distinct quiescence features – cellular projections – regulate quiescence induction and reactivation. It revealed that projections are involved in guiding …
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In Vitro studies of factors which may influence ligand binding, function, immunogenicity and genetic regulation of the Beta-2 adrenergic receptor in asthma
This thesis records a series of experiments conducted to gain further insight into factors which influence the expression, ligand binding and functional activity of the beta-2 adrenergic receptor. These studies were prompted by previous reports that the postulated beta-2 adrenergic receptor …
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DNA binding economies
… demonstrate the framework with an application to genetic regulation. Genetic regulation determines how DNA is read and interpreted, is responsible for cell specialization, reaction to drugs, metabolism, etc. Improved understanding of regulation has potential to impact research on genetic diseases …
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Genetic and Hormonal Regulation of Worker Behavioural Development in Honey Bees
How such plastic physiological and genetic regulation mechanisms for behavioral development might have evolved in the highly eusocial insects has been studied only theoretically. I performed three experiments with male honey bees (drones) to investigate how mechanisms regulating worker behavioral …
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Decoding CD4+ T cell activation by multi-modal phenotyping
… that underlie T cell activation and their genetic regulation with a focus on two functional read-outs: transcriptomics and image-based profiling. In the first chapter, I optimise a protocol for pooled CRISPR-KO screens in primary CD4+ T cells with single-cell RNA sequencing as a read-out, …
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Molecular Study of Diapause via Generation of Two CDNA Libraries and Partial Cloning of the Ecdysone Receptor in <em>Sarcophaga crassipalpis</em>.
… genes during the diapause syndrome. The genetic regulation of diapause in <em>S. crassipalpis</em> is also of interest. This species enters diapause during metamorphosis, which is under regulation of the steroid hormone 20-hydroxyecdysone (20-HE). Because the metamorphic system is …
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Anomalous diffusion of mRNA in the cytoplasm of HeLa cells
… and functions, as well as gene expression and genetic regulation. We study the motion of individual messenger RNA molecules in the cytoplasm of HeLa cells. RNAs are imaged in live cells via total internal reflection (TIRF) microscopy. In order to visualize individual RNA molecules expressing …
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