Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 84 for “"Genetic model"”.
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Inference on a genetic model
… on the mutation rates α₁ and α₂ of a population genetic model introduced by Moran [Proc. Camb. Phil. Soc. 54 (1958), pp. 60-71]. The deductive theory by approximate methods of such models has reached an advanced stage but little has been done along the line of statistical inference. Moran's model …
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p53 in a Genetic Model: Illuminating Adaptive Radiation Responses
… and genomic instability, indicating in our model, apoptosis is important for maintenance of genomic stability in response to ionizing radiation. I also examined a global transcriptional change in response to ionizing radiation in the absence of Dmp53. Only 35 genes were constantly radiation …
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A longitudinal behavior genetic model for ordered categorical variables
A model for the analysis of longitudinal twin data consisting of ordered categorical variables was proposed. Proportional changes in response categories across time were modeled within growth curve by means of mean and variance changes in underlying continuous variables. Variances of the growth …
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Taphonomy and Palaeoecology of multi-element skeleton invertebrates: a genetic model for exceptional preservation
… in their features and origin. Three different genetic mechanisms, such as multiple in situ reworking, storm deposition and autochthonous accumulation can be inferred. The third case focused on regular echinoid and spatangoid mass accumulations, which are extremely rare in the fossil record of …
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The Uranium Mineralization of the Macusani District, Southeast Peru: Mineralogy, Geochemistry, Geochronology and Ore-Genetic Model.
Uranium mineralization of the Quenamari Meseta, Macusani District, SE Peru, is hosted by peraluminous, sillimanite-andalusite-muscovite-biotite rhyolites of the 12.3 - 6.8 Ma Macusani Formation of the Miocene-Pliocene Quenamari Group. The main ore mineral, meta-autunite, (Ca[(UO2)(PO4)]2(H2O)6-8), …
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Brachypodium distachyon as a genetic model pathosystem to study resistance against fungal pathogens of small grain cereals
… distachyon (Bd) has the potential to serve as a model pathosystem relevant to small-grain cereals. Chapter 3 provides evidence of compatibility between Bd and the main causal agents of FHB and shows that symptom development mirrors closely that in wheat. Natural variation in disease resistance …
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Drosophila melanogaster Genetic Model of Parkinson’s Disease: phytotherapy approach for a new and more sustainable pre-clinical investigation
Drosophila melanogaster (Dm) is a valuable genetic model for exploring molecular, genetic and cellular aspects of neurodegeneration in Parkinson's disease (PD), for further understanding its etiology and pathogenesis and making valid contributions to drug screening. This study used two …
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Characterization of the Roman lines/strains of rats as a genetic model of psychiatric disorders: a behavioral and brain dialysis study
… it is most likely that the combination of genetics, early life adverse events, and ongoing stress may ultimately determine the individual vulnerability to stress-related disorders, such as depression. Therefore, the development and characterization of animal models of vulnerability and …
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Parsing genetic models
… of computer vision applications for parsing genetic models. Genetic models are a visual illustration often used in the biological sciences literature. These are used to demonstrate how a discovery fits into what is already known about a biological system. A system that determines the …
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An investigation of genetic polymorphism in association with Type 2 diabetes and metabolic syndrome.
… countries. Various studies have suggested the genetic susceptibility to the disorders. The main aim of the thesis was to investigate the putative association of single nucleotide polymorphisms with Type 2 diabetes (T2D), metabolic syndrome (MetS) and the major components of metabolic syndrome. …
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Changes in Skeletal Muscle Sarcoplasmic Reticulum Calcium Handling and Regulatory Protein Content in Congestive Heart Failure
… function. The purpose of this study was to use a genetic model of heart failure, the SHHF rat, to examine the levels of regulatory calcium handling proteins to determine if changes in the amounts of RyR, DHPR, SERCA1, SERCA2, Csq and CaM are altered in congestive heart failure. A significant …
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Exploring the impact of polygenes on genetic inheritance model identification, with application to Familial Colorectal Cancer Type X (FCCTX)
Although a genetic inheritance pattern has not yet been identified, there seems to be a hereditary component for some types of cancer. The focus of this thesis is on identifying the factors that enable correct identification of genetic inheritance models. Exploring this topic involved complex …
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Optimal Management of a Common Property Pest Under Risk: An Application to the Corn Rootworm
An integrated pest management model is developed for the northern corn rootworm, Diabrotica longicornis, and the western corn rootworm, Diabrotica virgifera, insect pests of corn. Uncertainty and risk aversion are incorporated into an economic threshold model. Two control actions, soil insecticide …
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Hypercontraction and Drosophila : a model system for the study of human myopathies
… dystrophies and cardiomyopathies. Development of model systems in which to utilize high-throughput screens for novel compounds will help in drug discovery for these diseases. In addition, genetic model systems will allow us to dissect the molecular and cellular pathways activated in response to …
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Single Cell RNA Sequencing Data Analysis and Applications in Caenorhabditis Elegans Embryo Development
… (hereinafter “C. elegans”) embryo. As a key genetic model organism, especially for embryo development, this nematode has an invariant cell lineage which was fully mapped, making it the ideal model in which gene expression patterns of individual cells could be used to construct the …
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A novel compound heterozygous NEB mutationin Korean patients with intellectual disability, epilepsy,and acongenital myopathy
… onset. I performed several conventional genetic tests to detect chromosomal aberrations, gene copy number variations, and candidate gene and mitochondrial gene mutations. After finding no abnormality ,I conducted whole exome sequencing (WES)in this family. After filtering the WES data, I …
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Dissecting the molecular mechanisms of germ cell development in the planarian Schmidtea mediterranea
… in germ cell development is limited to classical genetic model organisms and would benefit from studying additional animal models. Freshwater planarian provides a unique system for studying germ cell development: these animals appear to form their germline post-embryonically from neoblasts, the …
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Pericyte deficiencies in a foxf2 loss of function mutant
… a zebrafish foxf2a loss of function mutant as a genetic model of CSVD to show pathological alterations in brain pericytes. Not only are there fewer brain pericytes across the lifespan, but these pericytes also exhibit morphological abnormalities like increased soma size, process length and …
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Developing C. elegans as a model to study Type 2 Diabetes Mellitus
<p>Caenorhabditis elegans has been studied as a model organism in various areas of biomedical research because it shares many conserved functions at molecular and genetic levels with humans. Specifically, it is an ideal organism to study heterogeneous metabolic syndromes such as Type 2 Diabetes …
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