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Showing 1 to 20 of 56 for “"Genetic linkage"”.
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Genetic linkage studies in Huntington's disease
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Genetic linkage of multiple modifications in the pig
Genetic engineering facilitates heritable modification of target genomes. Modifications can be site-specific or random. Though inefficient, homologous recombination allows for precise genome modification. Random integration can be very efficient, but lacks the opportunity to control the orientation …
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New Score Tests for Genetic Linkage Analysis in a Likelihood Framework
<p>Linkage analysis has been the successful primary tool for mapping many Mendelian traits and some complex traits until the genetic analysis paradigm shifted from rare Mendelian disease mapping using family data to the common variant-common disease mapping mainly using unrelated case-control data, …
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Genetic linkage and association studies in celiac disease: discoveries from whole genome analysis
… by inflammation in the small intestine of genetically predisposed individuals caused by inappropriate immune response to gluten, a protein enriched in some of our common grains (wheat, rye and barley). The toxicity of gluten is manifested by the autoimmune action of T-lymphocytes on mucosal …
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Development of a Genetic Linkage Map of Broccoli and Identification of QTL Associated With Glucosinolate Variability
… experiment then demonstrates how the broccoli genetic linkage map can be used to identify genetic factors affecting qualitative and quantitative differences in health promoting compounds. QTL analysis in this experiment identified seven QTL on six linkage groups associated with the variability …
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Development of microsatellite (SSR) marker multiplexes for future construction of a genetic linkage map for pear (Pyrus communis L.)
Recent advances in the field of plant genetics and application of molecular technologies has lead to greater understanding of various crop genomes and their organization.The applications of these techniques include molecular markers which have been used to examine DNA variation within crop species. …
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Genetic linkage map of LCP 85-384, genetic diversity of a S. spontaneum collection and the contribution of S. spontaneum to Louisiana commerical germplasm
… (SRAP) marker technique was used to assess genetic relationships and diversity among genotypes of Saccharum and allied genera. In the SRAP technique, the primers were arbitrarily designed with an AT- and GC-rich motif to anneal introns and exons, respectively. The level of polymorphism …
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Towards an Understanding of Genetic Control of Processing Quality Traits in Blackcurrant (<i>Ribes nigrum</i> L.)
… analysis and a new high-density quality-specific genetic linkage map and quantitative trait loci association with major quality compounds such as anthocyanins, sugars, organic acids and other polyphenols were developed. This contributed to the identification of significant associations between 28 …
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Extending the Scalability of Linkage Learning Genetic Algorithms: Theory and Practice
… formation. It also observes that the linkage learning genetic algorithm has a consistent, sequential behavior instead of different behaviors on different problems as was previously believed. Moreover, the competition among building blocks of equal salience is the main cause of the …
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Identification of a mutation affecting plasmid establishment in Escherichia coli K-12
… coli K-12 strain JF55 has been located on the genetic linkage map. This mutation maps at approximately min 48 and is contransducible with purF. A new use of the process of zygotic induction has been explored to indirectly test the ability of an Est⁻ strain to support the first stage in plasmid …
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Genomic characterization of multi-parental populations of sorghum and rice
… International Rice Research Institute (IRRI) on genetic analysis of two important cereal crops, sorghum and rice. Research presented in chapters 1 and 2 was performed at UIUC under the supervision of Dr. Patrick J. Brown, and research presented in chapter 3 was performed at IRRI under the …
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Genetic and Sex Steroid Hormone Contributions to the Sexual Dimorphism in Murine Experimental Allergic Encephalomyelitis
… EAE had important implications on the degree of genetic susceptibility necessary to result in disease. We also found that of the many quantitative trait loci (QTL) identified to date, genetic linkages to mouse chromosomes 7 and 11 were strongly associated with susceptibility to EAE. Further, the …
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Molecular Genetics on the Genus Glycine: I. Phylogenetic Study of the Subtribe Glycininae. II. Development of a Universal Soybean Genetic Map
During the last decade various soybean genetic linkage maps have been developed based not only on morphological and biochemical traits but also on molecular traits such as RFLP, RAPD, AFLP, and SSR data. None of these, however, has been associated with specific chromosomes of soybean. Therefore, …
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Flavour quality factors and its regulation in red raspberry (rubus idaeus)
Breeding in red raspberries is hampered by genetic incompatibility between varieties and a long juvenility period. Molecular breeding efforts in red raspberry have provided viable applications to incorporate disease resistance in new varieties. This approach could also be applied in developing …
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Isolation of innate immune response genes, expression analysis, polymorphism identification and development of genetic markers for linkage analysis in common carp (Cyprinus carpio)
… caused by cyprinid herpesvirus-3 (CyHV-3). Genetic variation in resistance to CyHV-3 infection was observed in different common carp strains, indicating that disease resistance can be improved by selective breeding. Marker-assisted selection is a breeding strategy that can accelerate genetic …
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Linkage mapping and genetic analysis of Trypanosoma brucei
… of T.brucei is now available and the diploid genetic system has recently been demonstrated to be Mendelian. This opens up the possibility of using a classical genetic approach to identify genetic loci that determine important phenotypic traits in this parasite, such as host specificity, drug …
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Molecular investigations of gene families encoding foldase enzymes in wheat
… is to develop molecular markers and identify any genetic linkage between these gene-specific markers and quantitative trait loci related to dough quality. Thus, this project involved the characterisation of the gene families encoding PDI and cyclophilin in wheat and assessment of these genes for …
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Genetic analysis of agronomic and enological traits in grapevine
… for their use as potential varietal markers. A genetic linkage map was constructed using Joinmap 3.0 software, following a pseudo-testcross strategy. Altogether271 simple sequence repeat (SSR) and 18071 SNP (Single Nucleotide Polymorphism) markers, and one CAPS marker were screened. Finally, a …
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Approach to the identification of sex-determining genes in the tilapia genome by genetic mapping and comparative positional cloning
… understood because of the variation in the genetic basis of sex-determination and the lack of morphological differences between sex chromosomes.</p><p>To facilitate QTL analysis of these traits, a genetic linkage map was constructed from hybrids between Oreochromis aureus and O. niloticus …
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A Genetic Approach towards Modulating Pre-Harvest Pod Shatter in Brassica napus (Oilseed Rape)
… separation in both B. napus and Arabidopsis. A genetic linkage map has been produced for the population and includes a number of candidate gene markers with established roles in fruit development in Arabidopsis. The linkage map was used as a basis to perform a QTL analysis where a number of loci …
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