Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Genetic lesions"”.
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The Mechanism of Tumorigenesis In The Immortalized Human Pancreatic Cell Lines: Cell Culture Models of Human Pancreatic Cancer
… most lethal cancer in the world. The most common genetic lesions identified in PDAC include activation of K-ras (90%) and Her2 (70%), loss of p16 (95%) and p14 (40%), inactivation p53 (50-75%) and Smad4 (55%). However, the role of these signature gene alterations in PDAC is still not well …
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Genomic analysis of mouse tumorigenesis
… We were interested in identifying the additional genetic lesions that got positively selected during tumorigenesis of these mice.
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The Role of HNF4A in Germ Cell Tumor Development
… copy number variations are the primary genetic lesions discovered in yolk sac tumors. Frequent gains of chromosome 20q13 provide clues as to the identity of important YST driver genes. We have determined that the Hepatocyte Nuclear Factor 4 alpha locus, which resides in this region, is …
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Investigation of Ring Finger Protein 8 in Mammalian Physiology and Pathogenesis
… followed by signal propagation to repair these genetic lesions. Interestingly, DSBs are not only hazardous, but are also programmed to occur during normal physiological processes such as immunoglobulin heavy chain (IgH) class switch recombination (CSR), an important mechanism for antibody …
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Investigating the initiation and progression of small cell lung cancer
… the need to better understand this disease, the genetic lesions that contribute to SCLC remain poorly characterized. To investigate the genetic aberrations that occur in SCLC, we analyzed the copy number alterations in tumors and metastases arising in a mouse model of SCLC (mSCLC), driven by …
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Network analyses for functional genomic screens in cancer
… B-cells that results from accumulation of genetic lesions, yet we have an incomplete understanding of all genes contributing to the disease and how they interact. To discover genetic mediators of this disease, we employ a genome-scale shRNA screen, and complement this data with differential …
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Epidermal growth factor and Transforming growth factor α motogenic activities are mediated by Epidermal growth factor receptor : Identification of signalling pathways involved in head and neck cancer
… that some of these tumours have additional genetic lesions. Resistance to Cetuximab has been associated with the genetic lesions to EGFR mutation and Ras mutations. These mutations are more common in Asian than Caucasian patients. More recently the Tyrosine kinase inhibitors (Gefitinib and …
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Mapping the Landscape of Acquired Vulnerabilities in Ovarian Cancer
Recent undertakings to identify the genetic lesions associated with ovarian cancer have noted the striking diversity of mutations occurring in this disease. This genetic diversity has complicated the search for novel therapies. However, recent data has suggested that one commonality of ovarian …
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Characterizing the Role of TLX1 in T-cell Acute Lymphoblastic Leukemia
… promote oncogenic transformation by accumulating genetic lesions and aneuploidy5,6,8–12. Characterization of TLX1 T-ALLs has suggested recurrent secondary mutations and colocalization with several transcription factors on the genome5,6,8,13. However, the precise mechanisms through which TLX1 …
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A chromatin-modifying protein is a context-dependent modulator of cell survival in hematopoietic malignancies
… are important drivers of leukemia. Many genetic lesions in hematopoietic malignancies lead to altered function of one or more chromatin-modifying proteins, often resulting in less differentiated cells that are more therapy-resistant. While a number of these lesions have led to development …
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Correlations Between Electron Microscopic and Classical Analytic Observations of Three Strains of Temperature-Sensitive Male Sterility Mutants of <em>Drosophila melanogaster</em>.
Spermatogenesis is a specialized case of cytodifferentiation involving the assembly of cellular components into haploid gametes. It is directed, presumably, by the sequential activation and repression of genes.
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Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor
… Since pre-B ALL induction requires secondary genetic events, we attempted to abrogate these E2A-PBX1-mediated effects by modulating expression of the Cdkn2a locus. Loss of Cdkn2a through deletion or Bmi1 overexpression failed to ameliorate the apoptotic response, suggesting that E2A-PBX1 …
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Whole body metabolic alterations as an early event in Kras-Driven cancers
… of non-small cell lung cancer driven by the same genetic lesions as our pancreatic cancer model displayed the opposite plasma BCAA changes. We subsequently demonstrated these changes were the result of tumor cell autonomous differences in BCAA incorporation and catabolism between the tumors of …
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Time to quit? Non-genetic heterogeneity in cell fate propensity after DNA damage
… cell cycles and the transmission of unresolved genetic lesions from one phase to the next. Furthermore, these mechanisms are also believed to underpin the responses of cells, both in normal and cancerous tissues, to those therapies that either directly or indirectly generate DNA damage. In …
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The Search for Regulatory Mutations in Gitelman Syndrome
… whole genome sequencing technologies has allowed geneticists to gradually uncover a wide spectrum of rare, deleterious mutations with large effect sizes, which are responsible for Mendelian diseases. Roughly 70% of human genes are single copy and have orthologs across the vertebrate lineage, …
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Regulation of the development and regeneration of the zebrafish posterior lateral line
… as high decibel and prolonged sound exposure, genetic lesions, age, illnesses, and ototoxic medications including aminoglycoside antibiotics and some chemotherapy drugs. Aquatic vertebrates such as zebrafish (Danio rerio) have a specialized class of mechanosensory hair cells found in the …
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The Long-Rage Directional Behavior of the Nematode C. Elegans
… In agreement with the results obtained by genetic lesions in the signal transduction pathways for thermotaxis and odortaxis, no rescue of directional behavior was observed when expressing TAX-4 in the thermosensory neuron AFD, or in the olfactory neurons AWB and AWC. Partial rescue of …
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Pax5 Haploinsufficiency Cooperates with BCR-ABL1 to Induce Acute Lymphoblastic Leukemia
… categories based on the expression of several genetically conserved chromosomal translocations including the t(9,22)[<em>BCR-ABL1</em>], t(1,19)[<em>TCF3-PBX1</em>], t(12,21)[<em>ETV6-RUNX1</em>], <em>MLL</em>rearranged leukemia’s, hyperdiploid and hypodiploid karyotypes, and T-lineage …