Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Genetic compensation"”.
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Investigating the Role of the Lysine-Specific Demethylase 4C in Pancreatic Ductal Adenocarcinoma
… of other KDM4 family member. To bypass this genetic compensation, we tested a preclinical pan-KDM4 inhibitor TACH107 and confirmed its efficacy in in vitro and in vivo PDAC models. Our studies identify KDM4C as an oncogenic molecule that sustains ERK signaling in KRAS mutant PDAC and can be …
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Temporal Comparisons on the Genetic Variation of the Dusky Gopher Frog (Lithobates sevosus)
<p>Monitoring temporal changes in genetic diversity within populations can provide vital information on future viability. The dusky gopher frog, Lithobates sevosus, exists in isolation with an estimated population size of 100-200 individuals, and previous research has shown that low genetic …
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Innate sensing and regulation during enteric caliciviruses infections
… We also show that Med23 knockout cells undergo genetic compensation, suggesting a critical role for MED23 in this pathway. Mechanistically, we show that MED23 interacts with IRF3, and is required for recruitment of RNA Polymerase II to promoters of IRF3-dependent genes. Taken together, our data …