Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 142 for “"Genetic architecture"”.
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The Genetic Architecture of Alopecia Areata
… affected hair follicles. Evidence supporting a genetic basis for AA stems from multiple lines of research, including increased risk of disease in first degree relatives, twin studies, and more recently, our initial family-based linkage study and genome wide association study (GWAS) in a cohort …
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INVESTIGATION OF THE GENETIC ARCHITECTURE OF CARDIOMETABOLIC DISEASE
… McFarlane, Aneja, & Sowers, 2003). Previous genetic studies with monozygotic and dizygotic twin pairs suggested a strongly heritable pattern for CMS risk factors, i.e. it is estimated that circulating lipid heritability ranges from 0.58 to 0.66 (h2HDL=0.61, h2LDL=0.59, h2TC=0.58, h2TG=0.66) …
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Genetic architecture and ecological speciation in Heliconius butterflies
… flow persists, recombination will break down the genetic associations between alleles that characterise emerging species and cause reproductive isolation. Accordingly, genetic architectures that impede recombination can slow the breakdown of linkage disequilibrium and facilitate speciation. …
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SNP Interactions in the Genetic Architecture of Blood Pressure
<p>Evidence suggests that there is a substantial genetic component to the regulation of blood pressure: BP) but most BP variance remains unattributed to specific genetic variants. Candidate gene studies show linkage to rare Mendelian disorders but inconsistent association with BP. Massive consortia …
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The Genetic Architecture Of Quantitative Disease Resistance In Maize
Several large scale quantitative genetic studies were conducted to better understand the genetic basis for quantitative disease resistance (QDR) in plants. The focus of these studies was the economically important disease of maize (Zea mays L. ssp. mays), northern leaf blight (NLB, caused by …
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Genetic architecture of transcript splicing in blood and phenotypic consequences
… the largest to-date investigation in to the genetic architecture of transcript splicing in blood, utilising a deeply-phenotyped cohort of 4,732 healthy adults, in addition to 638 adults presenting to intensive care units with sepsis. I first explore the genetic architecture of transcript …
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Genetic architecture of reproductive and growth traits in laboratory mice
… of means to determine adequacy of various genetic models and obtain estimates of their parameters. Four genetic models tested were: (1) containing additive-dominance effects only, (2) adding non-allelic interactions, (3) containing additive and dominance autosomal and sex-linked effects and …
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The Genetic Architecture of Juvenile Migration in Rainbow Trout (Oncorhynchus mykiss)
… life history, little is known of the underlying genetic architecture modulating this adaptive tactic. Using quantitative and molecular genetic techniques I describe the genetic basis of the marine migratory life history in three focused research chapters.</p> <p>In the first I conduct a …
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Integrated approaches to elucidate the genetic architecture of congenital heart defects
… and animal models have supported a substantial genetic component for CHD. However, gene discovery in CHD has been difficult due to the extreme locus heterogeneity and the lack of a distinct genotype–phenotype correlation. Currently, genetic causes are identified in fewer than 20-‐30% of the …
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Functional and cross-trait genetic architecture of common diseases and complex traits
… for learning about diseases and traits from genetic data. First, I introduce a method for partitioning heritability by functional annotation from genome-wide association summary statistics, and I apply it to 17 diseases and traits and many different functional annotations. Next, I show how to …
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Background-dependent genetic architecture of Fusarium head blight resistance in U.S. hard winter wheat
… of QTL combinations and the genomic architecture of introgression populations remain incompletely understood. This study evaluated the effects of three major FHB resistance QTL, Fhb1, Fhb7, and Fhb9, in four U.S. hard winter wheat genetic backgrounds (Guardian, KS Providence, NE18445, …
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Understanding the genetic architecture of secondary domestication traits in Field Pennycress (Thlaspi arvense L.)
… the limited research on pennycress breeding and genetics and aims to establish and characterize a global diversity panel of wild pennycress accessions, two biparental recombinant inbred populations, and three independent EMS-derived mutants to contribute knowledge and resources to understand …
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Genome-wide Analyses of Recombination and the Genetic Architecture of Virulence Traits in Cryptococcus
… to virulence, yet our understanding of the genetic architecture of such traits is limited. In the studies reported here, I describe the first genome-wide analyses of recombination in C. neoformans and C. deneoformans and provide the first high-resolution genetic mapping studies of virulence …
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The genomics behind beauty: disentangling the complex coat color genetic architecture of gir breed
… (Ne) allow the characterization of population genetic structure, whereas genome-wide association studies (GWAS) enable the investigation of the genetic architecture underlying coat color. In this study, phenotypic records from 50,341 animals classified into 25 coat color categories were used, …
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Genetic architecture of multiple disease resistance in one maize chromosome segment substitution line population
… resistant (MDR) varieties is critical. While the genetic basis of resistance to multiple fungal pathogens has been studied in maize, less is known about the relationship between fungal and bacterial resistance. Bacterial leaf streak (BLS) is a foliar disease of maize caused by Xanthomonas vasicola …
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Leveraging biological pathways and gene networks to understand the genetic architecture of diseases and complex traits
… connectivity is highly informative for disease architectures, but the information in gene networks may be subsumed by regulatory annotations, such that accounting for known annotations is critical to robust inference of biological mechanisms.
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Genetic architecture, genecology and phenotypic plasticity in seed and seedling traits of yellow-cedar : (Chamaecyparis nootkatensis (D.Don) Spach)
… was to estimate the amount and distribution of genetic and environmental variation, and correlations between genetic variability and seed source origin, of yellow-cedar (Chamaecyparisnootkatensis (D. Don) Spach). Variation was measured for traits of seed, and for morphological and physiological …
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The Genetic Architecture of Grain Quality and its Temporal Relationship with Growth and Development in Winter Malting Barley (Hordeum vulgare)
This thesis explores the genetic architecture of malting quality within the Virginia Tech barley breeding program, and discusses implications for imposing selection on complex traits that are difficult to phenotype. Malting quality measures are destructive, and can not be performed before selection …
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Investigation of winter wheat sowing date management and genetic architecture of malting quality in winter barley and milling/baking performance in soft red winter wheat
… or expensive to measure. In Chapter II, the genetic architecture of end-use quality is investigated in two soft red winter wheat bi-parental (Pioneer '25R47' / 'Jamestown' and Pioneer '26R46' / 'Tribute'). Both populations were genotyped with a public 90,000 wheat iSelect SNP-Array, grown …
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Developing a gene model for simulations that incorporates multi-species conservation
The genetic architecture, the number, frequency, and effect size of disease causing alleles for many common diseases including Type 2 Diabetes is not fully understood. Genetic simulations can be used to make predictions under specified genetic architecture models. Models whose predictions are …
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