Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Genetic Therapy"”.
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Mechanisms of Cell Death Initiated in Herpes Simplex Virus Thymidine Kinase Expressing Colon Tumor Cells Treated with Ganciclovir and UCN-01
… (GCV), has shown great promise for the genetic therapy of many cancers, but most patients have had only a partial or minimal response to the therapy. After screening a panel of two drug combinations, our laboratory has shown that the combination of GCV and the protein kinase inhibitor …
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Site-Specific Genome Engineering in Mouse Primary Fibroblasts
Site-specific genome engineering is a powerful tool for medical therapeutics and basic scientific research. As the name implies, site-specific genome engineering describes the ability to add or subtract nucleic acid information in a precise, controlled manner within the genome. This technology has …
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Site-Specific Genome Engineering in Mouse Primary Fibroblasts
Site-specific genome engineering is a powerful tool for medical therapeutics and basic scientific research. As the name implies, site-specific genome engineering describes the ability to add or subtract nucleic acid information in a precise, controlled manner within the genome. This technology has …
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Investigating Feeding Omega-3 Polyunsaturated Fatty Acids and/or Soy Protein Isolate to Female pck Rats on Polycystic Kidney Disease and Related Complications
Polycystic kidney disease (PKD) is a genetic disorder characterized by multiple benign cysts along the epithelial lining of the kidneys. As PKD progresses, cyst growth increases kidney volume, decreases renal function, and may eventually lead to end stage renal disease. In addition to renal …
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Precision Gene Editing for Muscle Diseases
… to do the many incredible things. Consequently, genetic mutations that cause muscle disease can have a profound effect on the afflicted individual. Gene editing tools like base editors and prime editors enable us to target and correct the underlying genetic causes of these diseases. Base editors …
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Examining the biophysics of ultrasound and contrast agent induced angiogenesis
… the past two decades, cellular, molecular, and genetic therapy attempts have been made in order to find a clinically relevant treatment. Ultimately, it is the invasiveness or lack of site specificity that provides the largest obstacle for therapeutic effectiveness of angiogenic treatments. …
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Prevention of Duchenne Muscular Dystrophy by CRISPR/Cas Therapeutic Genome Editing
… human body and hence muscle diseases caused by genetic mutations have a profound and systemic impact on human health. Duchenne muscular dystrophy (DMD) is a lethal neuromuscular disorder, caused by mutations in the DMD gene on the X chromosome, which consists of 79 exons encoding dystrophin …
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Glucose-6-Phosphatase in Metabolic Disease and Cancer
… initiated by G6PC deletion. We found modest genetic silencing of c-Myc normalized genes and metabolites related to glycolysis and the pentose phosphate pathway. In both the liver and a hepatocyte cell line, suppressing c-Myc attenuated the accumulation of lactate and urate, despite persistent …