Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Genetic Structures"”.
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Population genetic structures and dispersal patterns of arthropods in New Zealand and the Ross Dependency, Antarctica
… of populations. This thesis assesses population genetic structures and dispersal patterns of arthropods in two geographic regions-Antarctica and New Zealand-using molecular techniques in conjunction with distributional data and dispersal experiments. Regional genetic divergence was revealed using …
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The Genetic Structure of the Kuwaiti and Failaka Island Populations: Y-chromosome & Mitochondrial DNA Variation
… This dissertation investigated the paternal genetic structure of the Kuwaiti and Failaka Island populations using 15 loci Y-STR data. In addition, the maternal genetic structure of Failaka Island has been investigated using mtDNA HVS-I sequence data. This is the first genetic study to …
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Genome-wide diversity assessment for genetic resource management of Eucalyptus dunnii, E. grandis, E. nitens and E. urophylla
… Symphyomyrtus. As such, the distribution of genetic variation in natural and breeding populations of these Eucalyptus species needs to be better understood to continue to inform developing breeding practices and effective conservation efforts. To achieve this goal, this study set out to …
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Tuning DNA binding and gene expression using zinc finger proteins and engineered promoters
… to a degree that is not possible using natural genetic structures.1 However, previous studies on promoter engineering have focused on natural transcription factors (TFs),2 including the lac repressor, which produces a switch-like “all-or-none” response.3 In this project, we worked to develop a …
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A proteomic approach for studying LTR retrotransposon host factors in saccharomyces cerevisae
… that resemble retroviruses, both in their genetic structures and replication cycles. Ty retrotransposition begins in the nucleus with the transcription of Ty RNA. Following translation of Ty proteins, virus-like particles (VLPs) assemble in the cytoplasm. VLPs contain Ty RNA and enzymes …
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The significance of cell-surface α2,3-linked Sialic Acid in Osteoclasts
<p>Osteoclasts are giant, multinucleated cells that, alongside osteoblasts, are central to maintaining physiologically healthy bone. The functions of osteoclasts and osteoblasts-degrading and depositing bone matrix, respectively-are paired in healthy bone tissue, thereby yielding no net bone loss …
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Adaptive scaling of evolvable systems
… of forms. A particular feature of models such as Genetic Algorithms (GA) [18, 12] is the incremental combination of partial solutions distributed within a population of solutions. This mechanism in principle allows certain problems to be solved which would not be amenable to a simple local search. …
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INVESTIGATING IMMUNE SYSTEM REGULATION THROUGH CROSS-DISEASE GENETIC ANALYSIS AND B CELL FATE DECISIONS
… cluster into families, suggesting a shared genetic mechanism. Common genetic causes might indicate shared pathogenic mechanisms that cross-disease therapies could target. In this thesis, I investigated the genetic relationship among nine immune-mediated diseases. I identified three different …
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Approaches to mitochondrial genome sequencing using the oxford nanopore minion device
Current DNA sequencing methods rely on polymerase chain reaction (PCR) to create sufficient copies of targeted DNA fragments to serve as a library. PCR and subsequent clean-up steps add considerable time and cost to the process and provide opportunity for introduction of amplification errors or …
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Identification and Characterization of the Cis-acting Elements Around the Murine cd4 Cnhancer
<p>The cluster determinant 4 (CD4) molecule is a transmembrane glycoprotein. CD4 is essential for normal T helper cell function and plays an important role in T cell development and activation. CD4 is encoded by a single gene located on chromosome 6 in the mouse and chromosome 12 in the human. Both …
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Identification and Characterization of Control Elements within the Murine CD4 Gene
<p>The control of CD4 gene expression is essential for T lymphocyte development. Since the molecular mechanism for the control of CD4 gene expression during T cell development had not been elucidated, a study of the factors that control CD4 gene expression may lead to further. Toward these goals, …
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The conservation genetics of the Clanwilliam cedar (Widdringtonia cedarbergensis)
… fires. This study set out to determine levels of genetic diversity and fitness within and among populations of the Clanwilliam cedar for the following reasons: (1) to assess the level of genetic diversity; (2) to screen the seed source for the replanting programme; (3) to locate vigorous seedling …
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Dissecting the genetic bases of severe malaria resistance using genome-wide and post genomewide study approaches
… gap, we applied various contemporary statistical genetic analytic approaches to malaria GWAS datasets of diverse malaria endemic populations. First, we accessed malaria resistance GWAS datasets of three African populations (N=~11,000) including Kenya, Gambia and Malawi from European Genome Phenome …
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Induced Cytotoxicity In Crebbp/Ep300Mut Head and Neck Squamous Cell Carcinoma
<p><strong>INDUCED CYOTOXICTY IN <em>CREBBP</em>/<em>EP300</em>mut HEAD AND NECK SQUAMOUS CELL CARCINOMA</strong></p> <p>Thomaia Pamplin</p> <p>Advisor: Curtis Pickering, Ph.D.</p> <p>Background: Head and neck squamous cell carcinoma HNSCC is the most common malignancy in the head and neck. Most …
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The Role of Nogo-A During Development of the Chick Central Nervous System
<p>Nogo-A is a potent inhibitor of axon regeneration that is expressed by myelin forming oligodendrocytes of the adult central nervous system (CNS). However, neuronal expression of Nogo-A during development suggests an additional role. Little is known about the putative functions of Nogo-A during …
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Epidemiología molecular en Escherichia coli procedente de fauna salvaje: resistencia antimicrobiana, virulencia y diversidad y diversidad genética
… the major circulating clones, the mechanisms and genetic platforms involved in the flow of resistance genes between humans, animals, and the environment, and potential wild reservoirs of zoonotic E. coli pathotypes. In the first and second chapters, population structure and antimicrobial …
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Genetic Mechanisms of Transcriptional Regulation in Childhood Acute Lymphoblastic Leukemia
… ALL, improving our understanding of the genetic basis of childhood acute lymphoblastic leukemia (ALL). Recent genome-wide association studies (GWAS) have identified germline genetic variations of ARID5B and, more recently, IGF2BP1 that are associated with susceptibility to ALL. …
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PAX3 expression, protein modifications and downstream target gene profiling in melanocytes and melanoma cells
… which encode proteins that have differing structures and are therefore likely to activate different downstream target genes. The presence of post-translational modifications has also been shown to alter the functions of the proteins. PAX3 regulates the maintenance of undifferentiated …
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Identifying the Molecular Cause of Extreme Endoplasmic Reticulum Dilation in Pediatric Osteosarcoma and Its Relationship to the Disease
<p>Pediatric osteosarcoma tumors are characterized by an unusual abundance of grossly dilated endoplasmic reticulum and an immense genomic instability that has complicated identifying new effective molecular therapeutic targets. Here we report a novel molecular signature that encompasses the …
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Investigating the Role of ZNF384 Rearrangements in Acute Leukemia
… most often, transcription factors or epigenetic modifiers. It has been shown that ZNF384-rearranged tumors have a distinct gene expression profile that is consistent between disease groups and N terminal partners. Genomic analyses of patient tumors has shown that ZNF384 fusions arise in …
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