Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Genetic Models"”.
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Parsing genetic models
… of computer vision applications for parsing genetic models. Genetic models are a visual illustration often used in the biological sciences literature. These are used to demonstrate how a discovery fits into what is already known about a biological system. A system that determines the …
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Understanding Potassium Homeostasis Using Human and Mouse Genetic Models
… of potassium transporters, I choose two genetic models of human potassium disorders, hypokalemic periodic paralysis (hypoPP) and pseudohypoaldosteronism type II (PHA2). Patients with hypoPP are characterized with ictal hypokalemia and muscle paralysis. HypoPP can be divided into familial …
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Improving Genetic Analysis with Augmented Experimental Designs
<p>Genetic analysis aims at providing useful genetic information that can be used in plant or animal improvement. Genetic data are obtained from measuring traits in field experiments. One of the common problems associated with the field experiments is the field variation due to the heterogeneity of …
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Estimation of Variance Components in Finite Polygenic Models and Complex Pedigrees
Various models of the genetic architecture of quantitative traits have been considered to provide the basis for increased genetic progress. The finite polygenic model (FPM), which contains a finite number of unlinked polygenic loci, is proposed as an improvement to the infinitesimal model (IM) for …
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Computational methods for high-throughput pooled genetic experiments
… have created new avenues of attack for classical genetics problems. This thesis develops and applies principled methods for analyzing DNA sequencing data from multiple pools of individual genomes. Theoretical expectations under several genetic models are used to inform specific experimental …
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The Importance of Multiple Study Areas in Landscape Genetics: The American Black Bear in the Rocky Mountains
… distribution. I used individual-based landscape genetics analyses in 12 study areas in western Montana and northern Idaho to assess the influence of landscape features on gene flow among American black bears (Ursus americanus). I compared the influence of landscape features among the study areas, …
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The Importance of Multiple Study Areas in Landscape Genetics: The American Black Bear in the Rocky Mountains
… distribution. I used individual-based landscape genetics analyses in 12 study areas in western Montana and northern Idaho to assess the influence of landscape features on gene flow among American black bears (Ursus americanus). I compared the influence of landscape features among the study areas, …
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The Impact of Impaired Cyclooxygenase-2 Activity on Mouse Brain Development: A Focus on Sex Differences
… (COX-2) knockin and COX-2 knockout mice, genetic models which mimic exposure to antipyretic drugs, impaired COX-2 activity was found to induce sex-dependent changes in the expression of various neuroimmune markers in the brain during development. Further investigations also suggested that …
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Genetic architecture of reproductive and growth traits in laboratory mice
… of means to determine adequacy of various genetic models and obtain estimates of their parameters. Four genetic models tested were: (1) containing additive-dominance effects only, (2) adding non-allelic interactions, (3) containing additive and dominance autosomal and sex-linked effects and …
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Role of Stat3 In Human Nk Cell Functions
… pathway. Previously, we found that K562 cells genetically modified to express membrane bound IL-21 (mbIL-21), which predominantly activates STAT3, induce robust expansion and activation of human NK cells. Further investigations revealed role of STAT3 in the transcriptional regulation of NKG2D, …
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Tuning of Neuronal Excitation by a Brain Specific Microrna MIR-128: From Targets to Behavior
… by the microRNA miR-128. I show using genetic models that endogenous miR-128 plays a powerful role in dampening the excitability of pyramidal projection neurons in the adult forebrain and demonstrate that the loss of this microRNA alone results in severe motor hyperactivity and fatal …
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Molecular Epigenetics in Evolution and Development
… questions. Current quantitative and population genetic models reflect the dominant view of evolution described above, and act as the foundation for both formal and informal descriptions and predictions of evolutionary change. Using results from recent work in molecular epigenetics, I consider …
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Characterizing the Role of the E. Coli Cytochrome Oxidase AppBCX During Intestinal Inflammation
… bd oxidase, AppBCX. Using both chemical and genetic models of non-infectious colitis we have shown that it allows E. coli to utilize low levels of oxygen early in inflammation. Additionally, we have characterized the regulation of this enzyme in vivo highlighting the delicate balance between …
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Computational analysis of cell-cell communication in the tumor microenvironment
… interactions in six syngeneic mouse tumor models. To identify specific receptor-ligand interactions that predict tumor growth rate and immune infiltration, we used receptor-ligand interactions as features in regression models. For the third study, we extended our scRNA-seq approach to …
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Tobacco carcinogen induced mouse lung adenocarcinoma cell lines as tools to identify novel lung cancer genes
… of the cases. Although elaborate lung cancer genetic models exist they do not really recapitulate the human disease. The development of a faithful mouse model suitable for the identification of the missing lung cancer driving oncogenes and mutations remains an unmet and urgent research call. …
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URANYL DEPOSITION IN UNCONFORMITY-RELATED DEPOSITS IN THE ATHABASCA BASIN: EVIDENCE FROM URANIUM SPECIATION IN HEMATITE AND GOETHITE
… at high temperatures under reduced conditions, genetic models for the formation of uranium deposits had almost invariably invoked the pivotal roles of soluble U6+ species for the transport of uranium-bearing fluids and their reduction to sparingly soluble U4+ as the deposition mechanism. …
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ECOLOGICAL PERSPECTIVES ON HOST-PARASITE COEVOLUTION
… their parasites. GFG systems are well-understood genetically and an important source of disease resistance for plant breeders. Therefore considerable effort has gone into studying their evolutionary dynamics in natural pathosystems and modelling the conditions under which long-term polymorphism …
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ADVANCED MRI FOR CARDIAC ASSESSMENT IN MICE
… used model for a number of diseases, induced by genetic modification or surgical intervention. When performing experiments in mice, in vivo magnetic resonance imaging (MRI) can be used to evaluate heart anatomy and function at multiple levels. Volumetric measurements of ventricle size at each …
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Paleomagnetic and mineral magnetic studies of zinc-lead ore deposits in the Metaline (Washington state, USA) and Midlands (Ireland) ore fields
… play an important role in the debate over genetic models for MVT - SEDER deposits, including the structural controls on ore mineralization, syngenetic versus epigenetic models, and the origin and migration pathways for hydrothermal fluids. The genetic controversy arises largely because of …
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Development of A Bayesian Joint Logistic Model to Better Study The Association Between Haplotypes and Disease
… With the ever-increasing applications of cancer genetics in epidemiology, there is great potential to identify genetic risk factors that would help identify individuals with increased genetic susceptibility to cancer, which could be used to develop interventions or targeted therapies that could …
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