Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Genetic Epidemiology"”.
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Genetic epidemiology of markers of genomic ageing
… loss, have been linked to cancer. The genetic architecture of these markers is not well understood and studies investigating associations with common age-related cardiometabolic conditions have been limited in their design, analytical methods, power and genetic instruments used. Only a …
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Type 2 diabetes in Sri Lanka : Genetic epidemiology and periodontal association.
Prevalence rates of type 2 diabetes and impaired fasting glyceamia (IFG) in Sri Lanka are high and an increasing number of people are succumbing to disease. Identifying people at risk of developing complications is a healthcare priority of the county to prevent morbidity and mortality. Type 2 …
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Genetic Epidemiology of Polyautoimmunity and Common Autoimmunity in Colombia — Proof of Principle
Introducción: Las enfermedades autoinmunes (EA) son responsables de una gran porción de discapacidad y morbilidad a nivel mundial. Generalmente, las investigaciones científicas se centran en una sola enfermedad, aunque los fenotipos autoinmunes podrían estar representados por efectos pleiotrópicos …
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The Genetic Epidemiology of Purging Disorder, Anorexia Nervosa, and Obsessive Compulsive Personality Disorder
… influence the development of eating disorders, genetic factors contribute notably to their etiology. Understanding genetic factors associated with eating disorders is important, as they can influence how these disorders are recognized, researched, and treated. This dissertation included two …
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Dairy products and cardio-metabolic health: aspects from nutritional, molecular and genetic epidemiology
… evaluating aspects of nutritional, molecular and genetic epidemiology to advance scientific understanding. I undertook research to describe dairy consumption patterns over time by evaluating nationally-representative data of the United Kingdom National Diet and Nutrition Survey. I observed …
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Genetics of hearing impairment and peripheral neuropathy in Mali
… populations. HI is caused by environmental and genetics factors. In many developing countries, environmental factors are reported to be the most prevalent aetiologies while genetic causes are predominant in the developed countries. Over 50% of congenital HI has a genetic origin with more than …
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Examining Alcohol Dependence and Its Correlates From A Genetically Informative Perspective
… disciplines, including developmental psychology, genetic epidemiology, and molecular genetics, to achieve our current understanding of environmental and genetic risk factors for AD as well as its variable developmental trajectories. Nevertheless, there is still much to be learned in order to …
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Genetic Predictors of Hyperglycemia Due to Hydrochlorothiazide Therapy
… and drug metabolizing enzymes; and pharmacogenetics appeared as the science that studies the relationship between drug response and genetic variation.</p> <p>Thiazide diuretics are the recommended first-line monotherapy for hypertension (i.e. SBP>140 or DBP>90). Even so, diuretics are …
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Genetic Variations in Type 2 Diabetes and Cardiovascular Disease: A Focus on Gene-Lifestyle Interactions and Mendelian Randomization
… complex diseases that result from lifestyle and genetic factors. Gene-lifestyle interactions are also believed to contribute to the etiology of these diseases. The aim of this thesis was to investigate gene-lifestyle interactions using the strongest T2D and CVD susceptibility genetic loci and to …
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Genetic Predictors of Metabolic Side Effects of Diuretic Therapy
… analytical strategies to identify and quantify genetic factors that contribute to the development of adverse metabolic effects due to thiazide diuretic treatment. I performed a genome-wide association study (GWAS) and meta-analysis of the change in fasting plasma glucose and triglycerides in …
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Investigation into the causal effect of iron metabolism on cardiovascular disease
… metabolism, and a combination of observational epidemiology, genetic epidemiology and causal inference methods. Results: The observational association of serum iron, ferritin, transferrin and transferrin saturation (TS) with risk of CHD and stroke was assessed in 16,906 male and 17,110 female …
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Identification of genomic factors using family-based association studies
… increasingly popular and important for detecting genetic associations of complex traits. However, it is well known that spurious associations could arise from statistical analysis without proper consideration of genetic relatedness of samples. Many methods have been proposed to guard against these …
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The role of Serum Amyloid A1(SAA1) in coronary artery disease
… remains unknown. In addition, no prior genetic epidemiology study has been conducted on SAA1. Methods and results: Genetic variant screening was performed using cord blood DNA samples from 96 anonymous, unrelated Singaporean Chinese neonates delivered in the National University Hospital, …
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Population-based genotype-phenotype correlation to stratify incident cases of motor neurone disease in Scotland from 2015-2017
… heterogeneity. Recent discoveries in the genetic landscape of MND have resulted in an accelerated research investment exploring aetiology of disease and basis of phenotypic variation. Scotland benefits from a culture of longstanding MND data capture and an integrated healthcare system. …
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Genetic and environmental modifiers of iron overload disease. Why do only some patients get serious health outcomes?
Type 1 genetic haemochromatosis causes iron overload and is most commonly caused by homozygosity for the HFE C282Y variant and to a far lesser extent other HFE C282Y and H63D genotypes. Haemochromatosis is one of the most common genetic conditions in populations of Northern European ancestry, with …
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Investigating the role of human genomewide heterozygosity as a health risk factor
Aim The aim of this study was to investigate the most commonly used approaches to measure individual genome-wide heterozygosity (IGWH) and to investigate whether IGWH can be considered as a health risk factor or a protective factor in humans. Methods This study was based on two samples from …
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