Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Genetic Code Expansion (GCE)"”.
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Acetylation regulates Thioredoxin Reductase activity and oligomerization
… enzyme in the Trx system and contains the 21st genetically encoded amino acid, selenocysteine (Sec). There were multiple experimentally identified TrxR acetylation sites with an unknown effect on TrxR activity. My thesis tested the hypothesis that programmed protein acetylation will enhance the …
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Bioorthogonal Tethering of Drug Fragments to Engineered G Protein-Coupled Receptors
… This thesis presents a novel strategy employing genetic code expansion (GCE) and bioorthogonal chemical reactions for tethering drug fragments adjacent to allosteric sites in GPCRs to increase their potency and enable fragment-based drug screening in cellular systems. C-C chemokine receptor 5 …
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Using Translational Switching to Investigate the SCN Clockwork
… expression of a transgenic copy. By using genetic code expansion (GCE), it is possible to create translational switches whereby the translation of a transgene is conditional on the provision of a non-canonical amino acid. Incorporation of an ectopic amber stop codon (TAG) into the coding …