Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 199 for “"Genetic Background"”.
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The genetic background of gestational diabetes mellitus
The aims of this work is to better determine the genetic background of gestational diabetes (GDM) and to examine how specific genes affect the development of diabetes post partum. In the DiPiS (Diabetes Prediction in Skåne) study we typed for HLA-DQB1 alleled, the transcription factor 7-like …
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Deciphering the genetic background of Systemic Sclerosis
Contains fulltext : 99157.pdf (Publisher’s version ) (Open Access)
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Marker-Qtl Associations: Comparisons of Genetic Background Effects in Maize
The third chapter was a study of the usefulness of several multivariate statistical techniques not commonly used in crop sciences for identification of marker alleles associated in some manner to QTL. Data from the S$\sb {4:6}$ lines per se and crosses to the Stiff Stalk and Lancaster testers were …
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Genetic Background and Genotype-Phenotype Correlations in Palmoplantar Epidermal Differentiation Disorders
… of the molecular basis of pEDDs, the genetic diagnosis remains unresolved in a subset of patients, and genotype-phenotype relationships are not yet fully defined. The aim of this thesis was to elucidate the genetic background and genotype-phenotype correlations in pEDDs through …
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Overview of the Genetic Background Influencing the Pharmacokinetics and Pharmacodynamics of Statins
… which can be attributable to a number of genetic factors and personal medication habits. This thesis aims to review the genetic factors affecting the pharmacodynamics and pharmacokinetics of statins.
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Clinical Diagnosis, Genetic Background and Treatment of Vitamin-D Resistant Hypophosphatemic Ricket
X-linked hypophosphatemia (XLH) is the most common heritable form of rickets. It involves loss-of-function mutations in the phosphate-regulating endopeptidase homolog X-linked (PHEX) gene, which give rise to the increase of fibroblast growth factor 23 (FGF23). Excess FGF23 reduces renal phosphate …
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Implications of the interactions between genetic background and dietary phosphorus on porcine muscle
… in this area, little research has examined the genetic mechanisms underlying the control of P utilization. Lack of understanding of the molecular response of skeletal muscle to dietary P and the influence of genetics has hindered our understanding of P homeostatic mechanisms. The objectives of …
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The influence of genetic background on drug resistance in the malaria parasite Plasmodium falciparum
… into 37 progeny from the NF54 × Cam3.II genetic cross using CRISPR/Cas9. The African NF54 parasite is considered wild-type and is broadly drug susceptible. The Cambodian Cam3.II parasite is multidrug-resistant owing to numerous mutations, including the R539T mutation in *pfkelch13*, a …
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The effects of noise exposure and genetic background on auditory-evoked behaviors in larval zebrafish
… (Danio rerio). Zebrafish have been a powerful genetic model species used in the study of development of auditory structures and exhibit a well-studied and robust escape response when presented with a loud acoustic stimulus. I used psychophysical methods to measure auditory sensitivity and …
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Identification of phenotypic variation across levels of cSOD activity in Drosophila melanogaster reveals that phenotypes are most influenced by second chromosome genetic background and sex at high cSOD activity
… in cSOD activity were on phenotypes across genetic backgrounds and between sexes. Analysis of variance (ANOVA), and the effect size partial eta squared (η2p) were used to partition the amount of variation attributable to sex, cSOD activity, and genetic background across the distal and …
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Unraveling the genetic determinants of virulence in Cryptococcus neoformans
… specific factors, including C. neoformans genetic background. C. neoformans has three major lineages: VNI, VNII, and VNB. VNI and VNII are both clonal and globally distributed, with the vast majority of disease caused by VNI. VNB is highly diverse and regional; disease caused by VNB …
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The feasibility of interspecific rescue of endothelial/hematopoietic lineage deficiency
… an endothelium/hematopoietic system from a rat genetic background and the other tissues and organs from a mouse genetic background. The first series of experiments of this thesis work were designed to test the feasibility for the interspecific chimeras (mouse-rat and rat-mouse) that can be made …
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Variable DNA methylation in the mouse genome: repetitive elements, unique regions and functional implications
… cited as the best examples of mammalian epigenetic inheritance. A recent screen in the C57BL/6J mouse strain identified over 100 candidate VM-IAPs providing novel insights into metastable epialleles. In this thesis, I revisit the phenotypic and epigenetic heritability associated with the …
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The Malleability of Gene Regulation in Healthy Individuals: Analyzing CRISPR-based Screens with Single-Cell RNA-Sequencing Readout across Genetic Backgrounds
… that has driven the field of quantitative genetics since its inception, is that of understanding the relationship between genetic variation and complex traits. In the last few decades, genome-wide association (GWAS) and quantitative trait studies have implicated thousands of genetic loci in …
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Genetics, behavior, and disease resistance in chickens
… designed to examine the interfacing of behavior, genetics, physiology and disease resistance in the domestic fowl. The principle objective was to obtain insights into the mechanisms involved in the responses of the domestic chicken to various husbandry situations. A second objective was to …
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Molecular Genetic Variation of Diaporthe Phaseolorum and Phomopsis Longicolla and Their Detection From Soybean Tissues
… hosts. In addition, AFLP data demonstrated that genetic variation of P. longicolla isolates were not correlated with their geographic locations. However, the genetic background of D. phaseolorum var. meridionalis isolates were related to their geographic locations and some biological …
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Role of 5-ht2c receptor density on behaviour in mice
… backcrossing of the mouse lines onto the C57Bl/6 genetic background the abnormal behavioural phenotypes were lost suggesting that 5-HT2C receptor function is particulary sensitive to the genetic background on which it is being expressed. In response to altered expression levels of 5-HT2C receptor, …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes and mycobacterium tuberculosis infections in mice
… and survival studies on both C57BL/6 and Balb/C genetic backgrounds. Our findings revealed that the function of CysLTR1 in bacterial infections is influenced by the host's genetic background and gender. Interestingly, CysLTR1 deletion did not impact survival or tissue pathology in C57BL/6 mice …
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Genetic dissection of variability in cognitive and locomotor phenotypes using Drosophila melanogaster
… is to further our understanding of the role of genetic variability in the diversity of phenotypic presentation seen in learning, memory, and neurodegenerative mutations using the Drosophila Synthetic Population Resource (DSPR). I utilized quantitative trait loci (QTL) mapping and directional …
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