Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Genes targeting"”.
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Identification and investigation of RNA-binding ligands
… of alternative splicing of a variety of genes. Targeting these repeats with small molecules could block the sequestration of MBNL1 and restore normal splicing levels, alleviating the pathogenesis of the disease. To that end, I have screened a library of select compounds, chosen for their …
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Analysis of cathepsin H-deficient mice and identification of a dense cluster of placenta specific peptidase genes
Cathepsin H deficient mice were generated by gene targeting. After confirmation of cathepsin H gene and activity inhibition by southern-northern-western blot analysis and enzyme assay, the cathepsin H deficient mice were analyzed. The first macroscopic observation didn’t show any alteration. The …
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Diversity in APOBEC3 and CCR5 host genes and HIV-1 in a South African population
… of Maraviroc. Several host cell APOBEC3 genes (A3D, A3F, A3G and A3H) have been shown to restrict HIV, and the HIV viral infectivity factor (Vif) protein serves to antagonize the action of APOBEC3 proteins, promoting viral replication. The CCR5 co-receptor and the HIV Env V3 loop have …