Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Genes, p53"”.
-
A Novel Drug Delivery System Incorporates a Functional Composite Scaffold Derived from Taxifolin with Potential Cytotoxic and Anticancer Effects on Triple Negative Breast Cancer
… molecular pathways, as evidenced by changes in genes (p53, p21, p27,and Bcl-2) using qPCR and protein levels (p53, p27, and Bcl-2) using Western Blot, suggesting its potential in targeted therapy. The optimised taxifolin-PCL electrospun scaffold enhances cell adhesion, reducing cell viability …
-
A Novel Drug Delivery System Incorporates a Functional Composite Scaffold Derived from Taxifolin with Potential Cytotoxic and Anticancer Effects on Triple Negative Breast Cancer
… molecular pathways, as evidenced by changes in genes (p53, p21, p27,and Bcl-2) using qPCR and protein levels (p53, p27, and Bcl-2) using Western Blot, suggesting its potential in targeted therapy. The optimised taxifolin-PCL electrospun scaffold enhances cell adhesion, reducing cell viability …
-
A Novel Drug Delivery System Incorporates a Functional Composite Scaffold Derived from Taxifolin with Potential Cytotoxic and Anticancer Effects on Triple Negative Breast Cancer
… molecular pathways, as evidenced by changes in genes (p53, p21, p27,and Bcl-2) using qPCR and protein levels (p53, p27, and Bcl-2) using Western Blot, suggesting its potential in targeted therapy. The optimised taxifolin-PCL electrospun scaffold enhances cell adhesion, reducing cell viability …
-
Modeling Epithelial Ovarian Cancer In The Mouse
… animal models studies of this disease's pathogenesis have been challenging. Not surprisingly, establishment of adequate screening tests for early disease stages, at which point the cancer would be curable, and advances in treatment approaches have been slow. Deficiency of tumor suppressor …
-
p53 in a Genetic Model: Illuminating Adaptive Radiation Responses
… genotoxic stress, the tumor suppressor protein p53 promotes adaptive responses, including cell cycle arrest, DNA repair, or apoptosis. How these distinct fates are specified through an action of a single protein is not known. To study its functions in vivo we produced a targeted mutation at the …
-
P53 Genes Act to Restrain Mobile Elements
Oncogenic stress provokes tumor suppression by p53 but the extent to which this regulatory axis is conserved remains unknown. Using a biosensor to visualize p53 action, we find that Drosophila p53 is selectively active in gonadal stem cells after exposure to stressors that destabilize the genome. …
-
Cooperative Tumor Suppression by ARF and p53
… by the inactivation of tumor suppressor genes and enhanced activity of oncogenes leading to deregulated cellular proliferation. Two tumor suppressor genes, p53 and Arf, play important roles in protecting cells against numerous biological stresses. In response to oncogenic signals, …
-
Valor prognóstico das expressões da proteína p53 e do fator de crescimento do endotélio vascular em pacientes com carcinoma epidermóide de esôfago submetidos a esofagectomia
As mutações no gene de supressão tumoral p53 estão entre as anormalidades genéticas mais comuns encontradas numa ampla variedade de tumores. Embora a função do gene p53 ainda não esteja completamente esclarecida, ele parece ser um fator de transcrição nuclear que controla a proliferação celular, a …