Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Gene-set analysis"”.
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Microarray-based gene set analysis in cancer studies
… addresses the development and application of gene set analysis methods to problems in microarray-based data sets. The work consists of three parts. In the first part a gene set analysis method (PCOT2) is developed. It utilizes inter-gene correlation to detect significant alteration in gene …
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Bayesian Hierarchical Latent Model for Gene Set Analysis
Pathway is a set of genes which are predefined and serve a particular celluar or physiological function. Ranking pathways relevant to a particular phenotype can help researchers focus on a few sets of genes in pathways. In this thesis, a Bayesian hierarchical latent model was proposed using …
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Investigating the effect of paralogs on microarray gene-set analysis
… experiment, researchers often shift focus from analysis of individual differentially expressed genes to analyses of sets of genes. These gene-set analysis (GSA) methods use previously accumulated biological knowledge from databases such as the Gene Ontology (GO) or KEGG to group genes into sets …
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Genetic Risk Factors for PTSD: A Gene-Set Analysis of Neurotransmitter Receptors
… in many afflicted individuals. The pathogenesis of PTSD is not well understood, and genetic mechanisms are particularly elusive. Neurotransmitter systems are thought to contribute to PTSD etiology and are the targets of most pharmacotherapies used to treat PTSD, including the only two FDA …
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Gene Set Analysis of Post-Lactational Mammary Gland Involution Gene Signatures In Inflammatory and Triple Negative Breast Cancer
… and Stein et al. (2004) conducted a detailed analysis of these changes in the mouse mammary gland. Their results showed that tissue remodeling during post-lactational involution period mimics wound healing and tumorigenesis like pathological conditions. This indicates that post-lactational …
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Understanding co-expressed gene sets by identifying regulators and modeling genomic elements
… phenotypes by identifying experimentally derived sets of functionally related genes with similar transcriptional profiles. These gene sets are then frequently subjected to statistical tests of association relating them to previously characterized gene sets from literature and public databases. …
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Genetic exploration of exercise associated sudden death in racehorses
… found to be an important underlying cause. The genetics underlying EASD have been largely unexplored in horses.Hypothesis: Thoroughbred racehorses with variants in ion channels and other arrhythmogenic genes are predisposed to a higher risk of EASD. Specific Aim1: This study aimed to identify …
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A Tail-Based Test For Differential Expression Analysis and Pathway Analysis In Rna-Sequencing Data
<p>RNA sequencing data have been abundantly generated in biomedical research for biomarker discovery and pathway analysis. Such data at the exon-level are usually heavily tailed and correlated. Conventional statistical tests based on the mean or median difference for differential expression likely …
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Risk factors associated with blood pressure variation in sickle cell disease in Cameroon
… that are considered relatively normal for the general population (i.e., lower than 140 mmHg). SCD patients, generally, have lower systolic, diastolic, and mean BP compared to age and sex-matched controls. Relative Systemic Hypertension (RSH) for SCD patients is defined as BP ranging from …