Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 65 for “"Gene-environment"”.
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Exploring Multivariate Gene-Environment Interactions: Models And Applications
… are driven by multiple risk factors, including genetic variants, environmental exposures and interactions between the two. The advent of GWAS in 2005 and subsequent methodological advances have increased our knowledge of the genetic risk factors underpinning complex diseases. In addition, some …
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Etiology of orofacial clefts, gene-environment interactions and folate
Contains fulltext : 146928.pdf (Publisher’s version ) (Open Access)
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Using Zebrafish Behavior to Study Gene-Environment Interactions After Chemical Exposures.
North Carolina State University Theses Genomic Sciences.
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Bayesian Statistical Methods In Gene-Environment and Gene-Gene Interaction Studies
… diseases such as cancer result from multiple genetic changes and environmental exposures. Due to the rapid development of genotyping and sequencing technologies, we are now able to more accurately assess causal effects of many genetic and environmental factors. Genome-wide association studies …
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Molecular basis of gene-environment interactions in the pathogenesis of asthma and COPD
… (GST) are potent antioxidants. In this work, genetic polymorphisms that alter GST enzyme activity were genotyped in a family-based childhood asthma cohort (341 families, n = 1508) and analysed to investigate whether they alter the risk of developing asthma when individuals are exposed to …
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Estimating the magnitude of gene-environment correlation for cognitive ability, personality, psychopathology, and height
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-12-01
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Using Genetic Epidemiologic Methods to Explore the Influence of Gene-Environment Interactions on Colorectal Adenoma Recurrence
… There is evidence to suggest that common genetic polymorphisms can modify the effect of environmental risk factors on colorectal neoplasia. Methods: Data on 1430 individuals were obtained from two chemoprevention trials, the Wheat Bran Fiber Trial (WBF) (1) and the Effects of …
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Infant emotionality moderates relations between maternal parenting in early childhood and children's reactivity and effortful control at 54 months: Differential susceptibility or gene-environment dual risk vulnerability
… accounted for by one of two explanatory models: gene-environment dual risk vulnerability or differential susceptibility. Predicting later levels of childhood reactivity, infants with high levels of emotional intensity were more vulnerable to maternal rejection than infants with low levels of …
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Investigating the role of ALDH3B2 and FUT2 as potential risk genes to colorectal cancer through computational analysis and gene expression study of colonic cells, and utilizing colorectal cancer cell lines to explore gene-environment interactions
… studies (TWAS) has brought to light numerous genetic loci known or predicted to be involved in conferring risk to various cancers. Using a systems genetics approach of GWAS and TWAS, this study sought to investigate two identified genes, ALDH3B2 and FUT2, in order to better understand their …
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Cortisol in Middle Childhood: Associations with Genetic Polymorphisms and Early Environmental Risk
… stress than others. The exploration of candidate genes and gene-environment interactions may be one promising window on risk versus resilience trajectories. However, prior work involving three polymorphisms (COMT Val158Met, MAOA-LPR, and 5-HTTLPR) has yielded well publicized but inconsistently …
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Genetics of Experience: Genetically Sensitive Approaches to Measuring Childhood Environment
Environmental experience is not free of genetic influence. Through genetically-influenced behaviours, genes can influence exposure to certain environments: gene-environment correlation. Particular genotypes may also be more or less sensitive to the effects of the environment: gene-environment …
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Robust numerical methods to solve differential equations arising in cancer modeling
… is a complex disease that involves a sequence of gene-environment interactions in a progressive process that cannot occur without dysfunction in multiple systems. From a mathematical point of view, the sequence of gene-environment interactions often leads to mathematical models which are hard to …
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Self-injurious and aggressive behaviour in Angelman, Cri du Chat and Cornelia de Lange syndromes
… behavioural phenotype to challenging behaviour (gene-environment interactions). Next, the phenomenology and correlates of self-injurious and aggressive behaviour in the syndromes were explored at a given level of behavioural specificity. Results showed that self-injury was more common in Cornelia …
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Exploring a Role for the Parkinson Disease-Linked GBA1 Gene in Host Responses to Infections
… arises from a combination of factors including genetics, environment, gene-environment interactions, sex and age. How these factors interact has yet to be elucidated. We have previously published roles for PD-linked genes in response to microbial infections in an effort to model gene-environment …
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Novel cardiovascular risk factors in childhood
… dysfunction (Study II-III); exposure to environmental tobacco smoke (ETS) affects heart rate variability (HRV), and whether this association is influenced by diabetes-risk HLA (Study IV). The aim of study V was to investigate in an animal model susceptible to vascular disease whether …
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The molecular genetics of bipolar affective disorder : South African populations, endophenotypes, and environmental influence
The identification of the genetic variants underpinning bipolar disorder (BPD) has been impeded by a complex pattern of inheritance that may include by genetic heterogeneity, genetic epistasis, gene-environment interactions, incomplete penetrance and variable expressivity. In this thesis three …
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Investigating the molecular underpinnings of major depressive disorder and the utility of biomarkers in the inflammatory cytokine pathway as aids for clinical diagnosis and treatment selection
… depressive disorder (MDD) is a complex, heterogeneous disorder<br/>characterised by a pathological distortion of emotional mood. There is evidence<br/>of both genetic and environmental risk factors for MDD, and gene-environment<br/>interactions may play a particularly important role. …
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Bayesian regularized quantile mixed models for longitudinal studies
… correlations in the presence of data heterogeneity and long tailed distributions of the disease phenotype is challenging, especially in the context of high dimensional regressions. Here, we aim at developing novel Bayesian regularized quantile mixed effect models to tackle these challenges. …
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Exploring Interactions Between DRD4 Genotype and Perceived Parenting Environment
… (SITSS). Results indicated that although no gene-environment interactions were found when examining child perceptions, a significant interaction emerged between DRD4 and parenting in predicting externalizing behaviors when using parent reports. Children without the 7-repeat allele appeared to …
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