Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Gene-Gene Interaction"”.
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Bayesian Statistical Methods In Gene-Environment and Gene-Gene Interaction Studies
… diseases such as cancer result from multiple genetic changes and environmental exposures. Due to the rapid development of genotyping and sequencing technologies, we are now able to more accurately assess causal effects of many genetic and environmental factors. Genome-wide association studies …
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Genome-wide Association Study of TDI-Induced Asthma in a Korean Population : Signofocant Association of a T-catenin(CTNNA3) and TRP channel gene-gene interaction
… 유전적 변이를 찾아보고 유의한 의미를 가지는 유전적 변이에 대해 유전자-유전자 (gene-gene) 상호작용 분석을 통하여 유전적 변이간의 관계를 알아보고자 한다. 연구방법: 직업성 천식인 TDI천식 환자 84명과 건강한 정상인 263명에 대하여 Affymetrix 500K 유전자칩을 사용하여 대량의 유전적 변이들의 유전자형(genotype) 결과를 얻었다. Quality control 을 통하여 대략 500,000개의 데이터에서 200,000개의 유전자변이가 제외가 되어 최종적으로 312,978 개로 연관성 …
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Genome data analysis, protein function and structure prediction by machine learning techniques
… information of a typical human genome has been generated at 2001 by Human Genome Project. However, since there are a huge amount of data, it is still a big challenge for people to understand them, and extract useful structure and function information, such as the function of genes, the structure …
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An Automatic Framework for Embryonic Localization Using Edges in a Scale Space
… computational system for the exploration of gene-gene interaction on Drosophila. Contour extraction of embryonic images is challenging due to many variations in embryonic images. In the thesis work, we develop a localization framework based on the analysis of connected components of edge …
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Appearance Based Stage Recognition of Drosophila Embryos
… host embryo, as well as spatial information of a gene expression region is indispensable input for the discovery of the pattern of gene-gene interaction. Manual labeling of stages is becoming a bottleneck under the circumstance of high throughput embryo images. Automatic recognition based on the …
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Genetic association between schizophrenia and type-2 diabetes
… have a high risk of T2D. In order to clarify a genetic association between these two conditions, this study was designed to investigate a genetic pathway that might be associated with both schizophrenia and T2D, and to explore whether clozapine could affect expression of the genes associated …
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Alignment, Clustering and Extraction of Structured Motifs in DNA Promoter Sequences
… the presence of these motifs play a key role in gene expression regulation. Discovering these patterns is an important step towards understanding protein-gene and gene-gene interaction thus facilitates the building of accurate gene regulatory network models. DNA sequence motif extraction is an …
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The relationship between genes associated with the pain pathways and the development of chronic shoulder pain and disability in South African breast cancer survivors
… include severe acute post-operative pain and genetics. Polymorphisms within genes functioning within the opioid signalling and pain pathways have been implicated in variability in opioid use and the development of chronic musculoskeletal pain and disability conditions. The SA population has a …
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Heredity in Parkinson's disease. From rare mutations to common genetic risk factors.
This study investigated genetic causes of Parkinson's disease (PD) and parkinsonism in southern Sweden. The extensive Lister Family with parkinsonism caused by duplications and triplications of the gene for alpha-synuclein (SNCA) was studied. Clinical, genetic and genealogical data were compiled …
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Machine Learning to Interrogate High-throughput Genomic Data: Theory and Applications
… which has attracted great recent interest. The interaction effects among risk factors, both genetic and environmental, are hypothesized to be one of the main missing heritability sources. Moreover, detection of multilocus interaction effect may also have great implications for revealing …
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The Natural and Orthogonal Interaction (Noia) Models For Quantitative Traits (Qts) and Complex Diseases
… dissertation focuses on developing methods for gene-gene/environment interactions and imprinting effect detections for human complex diseases and quantitative traits. It includes three sections: (1) generalizing the Natural and Orthogonal interaction (NOIA) model for the coding technique …