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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 227 for “"Gene silencing"”.

  1. Gene silencing in plants : mechanisms & spread

    Dedic-{u0301}Hagan, Jasmina2004

    aus-cath Repository record

  2. Gene silencing in plants : mechanisms & spread

    Dedic-{u0301}Hagan, Jasmina2004

    anu Repository record

  3. Mechanisms of piRNA-guided co-transcriptional gene silencing

    Eastwood, Evelyn LouiseUniversity of Cambridge2022

    … depends on the Panx-induced co-transcriptional silencing (PICTS) complex, which contains Panx, Nxf2 and Nxt1. PICTS operates at the interface between piRNA-guided Piwi and heterochromatin effectors. While the N-terminal region of Panx is known to deliver the transcriptional silencing signal, the …

    cambridge Repository record

  4. IMPACT OF ACLY GENE SILENCING ON HEPATIC LIPID METABOLISM

    RODA, SILVIAUniversità degli Studi di Milano2026

    … partire dal citrato mitocondriale. L’acetil-CoA generato costituisce un precursore fondamentale sia per la de novo sintesi degli acidi grassi, attraverso la sua conversione in malonil-CoA mediata dell’acetil-CoA carbossilasi (ACC), sia per la biosintesi degli steroli tramite la via del …

    milano Repository record

  5. Sequence-specific gene silencing by transitive signals in plants

    Bleys, AnnickGhent University. Faculty of Sciences2006

    … field that aims at unraveling the process of RNA silencing, in particular of transitive silencing. In the first, application-oriented part of the thesis, we examined the potential of transitive silencing as a tool for functional genomics, and in the second, more fundamental part, we focused on …

    ghent Repository record

  6. The development of gene silencing strategies for plant parasitic nematodes

    Dalzell, JohnathanQueen's University Belfast2011

    … Although RNAi has been used widely to probe gene function in PRNs, this current body of work highlights a number of serious and potential issues which should be considered in future experimental designs.<br/><br/>Taken together, the data presented in this thesis: reveal that nematode …

    qu-belfast Repository record

  7. Gene discovery in Catharanthus roseus using virus induced gene silencing

    Payne, RichardUniversity of East Anglia2015

    This thesis presents the use of Virus Induced Gene Silencing (VIGS) for the discovery of enzymes and transporters involved in monoterpene indole alkaloid (MIA) metabolism in the medicinal plant Catharanthus roseus. C. roseus is the source of a number of MIAs that are used as chemotherapeutic agents …

    east-anglia Repository record

  8. piRNA-dependent transcriptional gene silencing during Drosophila oogenesis and embryogenesis

    Fabry, Martin Heinrich UlrichUniversity of Cambridge2020

    … effects of transposons, thus maintaining transgenerational genome integrity. In Drosophila melanogaster ovaries, piRNA-Piwi complexes localise to the nucleus and scan nascent transcripts for transposon expression by using complementary antisense piRNAs as guides. Following target engagement, …

    cambridge Repository record

  9. Sex in Cryptococcus: Signaling, Mating-type Locus Evolution and Gene Silencing

    Hsueh, Yen-Ping2008

    <p>Fungi have a genetically controlled sex determination system, which is governed by a small, sex-specific region in the genome called the mating-type locus (MAT). In the basidiomycetous yeast Cryptococcus neoformans, the pathogen that causes cryptococcal meningitis and cryptococcosis, sex has …

    duke Repository record

  10. The role of RNAi genes in Neurospora crassa post-transcriptional gene silencing

    Reustle, Lindsay A.University of Missouri--Columbia2014

    Meiotic silencing was first identified in the bread mold Neurospora crassa (by our group and others) and has since been discovered in worms, mice, and humans. Neurospora is an excellent model organism in that it is inexpensive, has a relatively small number of genes, and a rapid life cycle with two …

    missouri Repository record

  11. Functional gene analysis in cultured vertebrate cells using siRNA mediated gene silencing

    Gruber, Jens2012

    Die Expression von Genen kann sequenzspezifisch durch small interfering RNAs (engl. kleine interferierende RNAs, siRNAs) in einem als RNA Interferenz (RNAi) bezeichneten Prozeß herunterreguliert werden. Die Anwendung von RNAi Technologie erlaubt die systematische Analyse von Genexpression und …

    goettingen Repository record

  12. VSG expression in African trypanosomes: Gene silencing, cell cycle and developmental control

    Hutchinson, Sebastian JohnUniversity of Dundee2016

    … coat. The trypanosome genome contains ~2,000 VSG genes, however only a single VSG gene is transcribed with several expression site associated genes (ESAGs) in a polycistronic transcription unit by RNA-polymerase I, from one of approximately 15 telomeric VSG expression site (VSG-ES). This produces …

    dundee Repository record

  13. Virus induced gene silencing of <em>Fusarium verticillioides</em> pathogenicity genes in maize

    Redfern, Jennifer M.2021

    1 PDF file (x, 99 pages)

    northern-iowa Repository record

  14. Exploring the specificity and mechanisms of siRNA-mediated gene silencing in mammalian cells

    Alemán, Lourdes MariaMassachusetts Institute of Technology2008

    … RNAs (siRNAs) are routinely used to knockdown gene expression. siRNAs bind to their target sequence and guide transcript cleavage and subsequent degradation. This type of silencing is associated with equivalent levels of RNA and protein knockdown. siRNA-mediated knockdown was originally thought …

    mit Repository record

  15. Characterization of the roles of Xrn1p in small-RNA-mediated gene-silencing pathways

    Getz, Matthew Aaron.Massachusetts Institute of Technology2019

    RNA interference (RNAi) is a small-RNA-mediated gene-silencing pathway that is involved in viral defense, transposon silencing, heterochromatin formation, and post-transcriptional gene silencing. Most RNAi pathways are initiated by long, dsRNA which is processed by Dicer into small interfering RNAs …

    mit Repository record

  16. PROTECTION OF ISCHEMIA REPERFUSION INJURY IN MURINE LIVER BY GENE SILENCING OF COMPLEMENT 3

    Zhang, Xusheng2011

    … activation. Thus, blocking complement 3 (C3) genes using a small hairpin RNA (shRNA) can potentially prevent liver IRI. Gene silencing of C3 in vivo was achieved via the administration of shRNA prior to IRI. Liver IRI was evaluated using histopathology, serum alanine aminotransferase (ALT), …

    uwo Repository record

  17. O6 – METHYLGUANINE – DNA METHYLTRANSFERASE (MGMT) GENE SILENCING USING RNA INTERFERENCE AND SENSITIVITY TO TEMOZOLOMIDE.

    Davis, Steven Michael2024

    nmu Repository record

  18. Virus-induced gene silencing and molecular marker mapping for Russian wheat aphid resistance in wheat

    Valdez, Victoria A., author, Haley, Scott D., advisor, Lapitan, Nora Lyssa V., advisor, Leach, Jan E., committee member, Chisholm, Stephen Thomas, 1972-, committee memberColorado State University. Libraries2010

    To view the abstract, please see the full text of the document.

    colostate Repository record

  19. Mobile RNA reveal differential requirements for gene silencing in C. elegans at single-cell resolution

    Ravikumar, Snusha2018

    … RNA (dsRNA) into animals can silence genes of matching sequence in diverse cell types through mechanisms that have been collectively called RNA interference. In the worm C. elegans, such organism-wide silencing relies on the transport of dsRNA to most cells and requires amplification …

    maryland Repository record

  20. Posttranscriptional gene silencing of p27 in primary prostate epithelial cells by small inhibitory RNA (siRNA)

    Mertelsmann-Voss, Christina

    … in p27 levels contributes to prostate tumorigenesis are still poorly understood. <br>The aim of this study was to establish a system to downregulate p27 protein in primary diploid prostate epithelial cells (PrEC) for prolonged periods in order to create a model for further studies on its …

    freiburg-diss Repository record

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