Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"Gene signature"”.
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A gene signature for Alzheimer’s disease using RNAi in C. elegans
… caused at least in part by the fact that its genetics are incompletely known. In our laboratory, we have developed a novel computational approach—Network-based Transcriptome-Wide Association Studies (nTWAS)—that seeks to identify the genes associated with AD by comparing gene expression …
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ENHANCING CARDIAC TRANSDIFFERENTIATION OF FIBROBLASTS USING SINGLE-CELL TRANSCRIPTOMICS ANALYSIS AND HIGH-THROUGHPUT CHEMICAL LIBRARY SCREENING APPOACHES
… and induced higher expression of cardiac genes. Further validations suggest that DMSO could function co-linearly with TGF-β or MEK/ERK signalling pathways, although this remains to be proven empirically. Next, single-cell transcriptomic studies revealed trajectory of cardiac …
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Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation To Promote Immune Suppression
… of DC-promoting transcription factor Irf4. Genetic inhibition of RA production by tumor cells or pharmacologic inhibition of RA signaling within the TME increased stimulatory monocyte-derived cells, enhanced T cell-dependent anti-tumor immunity and demonstrated striking synergy with immune …
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Transcriptomic signatures of recurrent tuberculosis disease and treatment response in HIV-infected individuals
… and specific, such as a blood-based RNA signature, would be an important new tool. Such a test may also facilitate monitoring of TB treatment, opening the possibility for customizing the duration of TB treatment to that necessary for cure. We previously discovered and validated a 16-gene …
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Loss of Ptdss1 in tumor cells improves anti-PD-1 therapy
… cells increased expression of IFNγ-regulated genes, including B2m, Cxcl9, Cxcl10, and Stat1. Loss of PTDSS1 in tumor cells also led to increased expression of MHC-I, which was associated with increased expression of cytolytic function related genes in CD8<sup>+</sup> T cells and increased …
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Chemical Biology Approaches to Interrogate Heat Shock Transcription Factor 1 Regulation in Cancer
… cell proliferation, inhibited the HSF1 cancer gene signature and arrested tumor progression in multiple therapy-resistant animal models of prostate cancer. The identification of a direct small-molecule HSF1 inhibitor provides a unique pharmacological tool for future HSF1 research and serves as …
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Determining Mechanisms of Response to Polo-Like Kinase 1 Inhibition In Non-Small Cell Lung Cancer
… cancer-related death worldwide. The discovery of genetic alterations in some patients (~15%) has made it possible to use targeted therapies without the use of chemotherapy. To identify potential therapeutic targets in NSCLC, we systematically evaluated two cancer cell line databases with …
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DEVELOPMENT OF A BIOINFORMATICS FRAMEWORK TO IDENTIFY CELL SUBPOPULATIONS FROM BULK TRANSCRIPTIONAL DATA
… samples are affected by the intrinsic heterogeneity of cells and tissue composition. Nevertheless, in bulk transcriptional profiling, each sample is evaluated without considering the presence of multiple subpopulations. This limitation might be extremely critical when analyzing bulk gene …
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Heterogeneity in vascular smooth muscle cell gene expression and its association with clonal proliferation in models of vascular disease
… datasets and expressed an activated, responsive gene signature in all three environments. This gene signature contains known regulators of plaque progression; suggestive that they may be candidates for those cells selectively proliferating in disease. Focusing on VSMCs from CL, the scRNA-seq …
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LNCFOXP3 CONTROLS CELL IDENTITY AND FUNCTION OF HUMAN REGULATORY T CELLS
… FOXP3 (lncFOXP3), a newly identified lncRNA gene located in close proximity to the FOXP3 gene locus. LncFOXP3 defines Treg identity with higher specificity than FOXP3 itself, since its transcription is detectable only in Treg. LncFOXP3 localizes in cytoplasmic and nuclear compartments, whilst …
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Sphingolipids Modulate the Inflammatory and Functional Response in mdx Mice
… (DMD) is characterized by progressive muscle degeneration and a chronic inflammatory response. Sphingolipid metabolites are associated with the generation or perpetuation of low-grade chronic inflammation critical in atherosclerosis, obesity and cancer. Dietary sphingolipids, however, can …
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Modularity in Somatic Cell Reprogramming
… emerged as a critical approach in personalized regenerative medicine that provides an exclusive platform to study human development ex utero, engineer complex tissues, and build new models of human disease. However, reprogramming human somatic cells is an inefficient and nebulous, ill-defined …
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Investigating The Interaction of Aurka and Ube2C In Colorectal Cancer Cells
… Previous research in our lab identified a gene signature on chromosome 20q associated with colorectal cancer progression. In this study, one of the genes in the signature, the ubiquitin conjugating enzyme UBE2C, was identified through preliminary bioinformatics analysis as a candidate for …
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Single-cell analyses of tumor-infiltrating immune cells
… the single-cell libraries obtained according to gene signature scores, we identified distinct high-level families of immune cells in specific tumor categories. Downstream differential gene expression analyses on the T cells across tumor categories revealed actionable targets that correlated with …
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The Role and Mechanism of The Homeobox Gene Hoxa9 In The Growth of Epithelial Ovarian Cancer
… poorly understood. <em>HOXA9</em>, a homeobox gene that is normally expressed in the developing female reproductive tract, is aberrantly expressed in EOCs and controls the morphologic features of these tumors. The differentiation pattern of a tumor is an important determinant of its clinical …
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Characterization of The Growth Factor Receptor Network Oncogenes in Lung Cancer
… which contributes to complex lung tumor heterogeneity allowing for drug resistance development. In this study, gene expression signatures of six GFRN oncogenes overexpressed in human mammary epithelial cells (HMECs) were generated to interrogate this pathway’s downstream crosstalk, beyond …
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The role of BET proteins in castration-resistant prostate cancer dissemination
… ADT are not singular, but diverse, and include gene amplification, mutation and even complete loss of receptor expression. Collectively, each of these AR adaptations contributes to a complex, heterogenous, ADT-resistant tumor that culminates in prostate tumor cells transitioning from epithelial …
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The novel roles of BCL6 and BATF3 in regulating human CD8⁺ T cell dysfunction
… T cells, yet the underlying molecular and epigenetic drivers remain incompletely defined. Here, we developed an in vitro repeated stimulation model to recapitulate features of human CD8⁺ T cell dysfunction and delineate transcriptional and epigenetic landscapes. Our analyses revealed that BCL6 …
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Integrative Analysis of Omics Data In Adult Glioma and Other Tcga Cancers to Guide Precision Medicine
<p>Transcriptomic profiling and gene expression signatures have been widely applied as effective approaches for enhancing the molecular classification, diagnosis, prognosis or prediction of therapeutic response towards personalized therapy for cancer patients. Thanks to modern genome-wide profiling …
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Characterizing the Hypothalamic Functions of Irx3 and Irx5 in Energy Balance Regulation
… evidence has suggested that postnatal neurogenesis in ARC contributes to energy balance regulation and obesity, little is known about the genetic factors that are involved in this process. Using marker gene staining, lineage tracing and single-cell RNA sequencing analyses, I demonstrate that …
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