Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Gene rearrangements"”.
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Detection of AR gene rearrangements and regulation of AR variant-driven prostate cancer models
… mechanisms including AR amplification, AR gene rearrangements, AR ligand binding domain mutations, altered expression of AR coregulatory factors, and the emergence of AR variants (AR-V). These resistance mechanisms allow AR to function in the presence of AR inhibitors, which creates …
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Μελέτη ανασυνδυασμού DNA σε υπερπλασίες του λεμφικού συστήματος και λεμφώματα
… investigating the possible existence of clonal gene rearrangements. Such rearrangements have been detected in a number of clinically benign entities but so far they have not been reported in clear reactive processes. We report here that 5/22 reactive processes analysed with IG and TCR gene …
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RET receptor activation targets expression of the pleiotropic cytokine interleukin-11
… carcinoma (MTC), whereas RET fusion oncoproteins generated by gene rearrangements are associated with papillary thyroid carcinoma (PTC). In gene expression screens, interleukin-11 was identified as a RET-responsive gene. We sought to characterize the expression of IL-11 in response to activation …
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DNA Secondary Structure in Human Disease and Gene Regulation
… DNA breakpoints at the leukemia-associated gene MLL in human hematopoietic stem cells coincide with sites of predicted DNA stem-loop structure and predicted topoisomerase II cleavage. This suggests a role for DNA secondary structure formation in mediating topoisomerase II-dependent DNA …
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In vivo and in vitro studies of immunodeficiency in Ataxia-telangiectasia
Ataxia-telangiectasia (A-T) is a rare neurodegenerative disorder caused by mutations in the ATM gene which has a central role in the cellular response to DNA double strand breaks, cell cycle checkpoint control and initiation of the intrinsic pathway of apoptosis. Ataxiatelangiectasia is classified …
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Complex evolution of mitochondrial genomes: lessons from salamanders
… Chapter Two describes the correlation between gene rearrangement/genome expansion and increased rates of substitution in salamander mitochondrial genomes. Most protein-coding genes maintain their position along the mutation gradient in rearranged/expanded mitochondrial genomes, and the genes …
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A Broad Analysis of Tandemly Arrayed Genes in the Genomes of Human, Mouse, and Rat
Tandemly arrayed genes (TAG) play an important functional and physiological role in the genome. Most previous studies have focused on individual TAG families in a few species, yet a broad characterization of TAGs is not available. We identified all the TAGs in the genomes of human, chimp, mouse, …
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The VH repertoire and clonal diversification of B cells in myositis and vasculitis
… and contributory role in disease pathogenesis. Therefore establishing the occurrence of highly-specific B cell antigen-driven adaptive immune responses within autoimmune disorders would provide a valuable understanding into the roles of B cells within these disorders. The work of this …
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Significance of Protein Interactions in Mediating AF9 Function
<p>Rearrangements of the MLL gene at chromosome band 11q23 have been associated with a heterogeneous group of lymphoid, myeloid and mixed lineage leukemias. MLL rearrangements occur approximately in 70% of infant leukemias and are also common in therapy-related leukemias where patients were …
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A NOVEL BRAF SIGNALING CASCADE THROUGH p-21 ACTIVATED KINASES REGULATES THYROID CANCER CELL MOTILITY
… on investigating the pathways that lead to pathogenesis with a goal to develop new therapeutics. If detected at an early stage, PTC is curable most of the time; however, for patients with aggressive and invasive forms of it, treatment options are limited and prognosis is poor. Predictors of death …