Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"Gene promoter"”.
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Characterization of the Human Cytomegalovirus UL75 Late Gene Promoter
<p>Gene expression during productive infection by the human cytomegalovirus (HCMV) occurs in an ordered and sequential manner, beginning with immediate early (IE), then early (E) and finally late (L) gene expression. Significant work has addressed the regulation of IE and E gene expression while …
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Functional study of ubiquitin C-terminal hydrolase-L1 gene promoter haplotypes
… have clearly been associated with various neurodegenerative disorders, including Alzheimer’s, Huntington’s and particularly Parkinson’s disease.<br/>The main and unique objective of this study was to identify any common Caucasian sequence variants in UCH-L1’s promoter, and to investigate whether …
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Cloning, sequencing and functional analysis of the chicken tyrosine gene promoter
… and the activation of the tyrosinase gene is characteristic of differentiated melanocytes. In order to study the mechanisms underlying activation of melanocyte-specific genes during differentiation in chick embryos, a chicken genomic DNA library was screened for tyrosinase-encoding …
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Identification and characterization of a chicken major histocompatibility complex class II[beta] gene promoter
… complex (MHC) contains a variety of genes. Among them, the class II genes encode proteins involved in antigen presentation to helper T cells, a key step in initiating immune responses. The regulation of class II gene expression has been extensively studied in mammals. Such studies …
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Propionate induces gluconeogenesis in dairy cattle through direct activation of the bovine cytosolic phosphoenolpyruvate carboxykinase gene promoter
… (PEP), a critical reaction for gluconeogenesis. The two isoforms of PCK, namely cytosolic PCK (PCK1), and the mitochondrial PCK (PCK2) are abundantly expressed in liver and kidney. Increased PCK1 activity and mRNA expression in liver is observed as feed intake recovers during early …
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Association between Chronic Hepatitis B Virus Infection and Interleukin-10, Tumor Necrosis Factor-α Gene Promoter Polymorphisms
… factor-a (TNF-α) and interleukin-10 (IL-10) gene promoter. We studied 412 Korean patients with HBV infection (72 inactive carriers, 261 chronic hepatitis, 79 liver cirrhosis) and 204 healthy individuals who recovered from HBV infection. We assessed polymorphisms in IL-10 gene promoter (-1082, …
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Methylation Change of Histone H3 and CpG Sites at the TIM-3 Gene Promoter in Response to Stimulation
… 세포에서는 자극에 의해 활성화 되었을 때 발현한다고 알려져 있다. 본 연구에서는 epigenetic 조절에 따른 TIM-3 전사 조절을 이해하기 위하여 T 세포를 사용하여 TIM-3 promoter에서의 epigenetic 변형을 분석하였다. 먼저 DNA methyltransferase inhibitor인 5-Azacytidine을 Jurkat T 세포에 처리하였을 때 TIM-3 발현이 증가하였다. 또한 TIM-3 promoter (-1500 ~ -1)에 CpG methyltransferase인 SssI로 메틸화 시켰을 때 …
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Nuclear respiratory factor 1: a novel inhibitor of the human gene promoter of the cardiac isoform of acetyl-coenzyme a carboxylase
… modulator controlling the expression of nuclear genes encoding mitochondrial proteins. Activation of 5'-AMP-activated protein kinase (AMPK) has been associated with enhanced NRF-1 gene promoter binding activity. Furthermore, NRF-1 has been linked with increased gene expression of carnitine …
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Characterisation and functional analysis of the chicken microphthalmia gene
… is known about the regulation of avian melanogenesis. There has only been one report of the characterisation of the chicken tyrosinase gene promoter, and only one full-length chicken microphthalmia cDNA (cmi9) has been identified to date.
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Regulation of Insulin and CHOP Gene Expression in Pancreatic Beta Cells
… to understand the mechanisms by which insulin gene expression is regulated in pancreatic beta cells. In addition to examining histone modifications on the insulin gene promoter, I focused on the effect of MafA modification on insulin expression. MafA is a transcriptional activator of the …
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Ενεργοποίηση του ογκογονιδίου ha-ras1 του ανθρώπου από ογκογονίδια ιών και κυττάρων
THE H-RAS1 ONCOGENE IS A MEMBER OF THE RAS ONCOGENE FAMILY. RAS GENES ARE ACTIVATED IN APPROXIMATELY 50% OF HUMAN TUMOURS. THEREFORE, THE UNDERSTANDING OF THEMECHANISMS OF THEIR ACTIVATION IS CONSIDERED TO BE VERY IMPORTANT FOR THE PROGNOSIS, DIAGNOSIS AND THERAPY OF CANCER. THIS THESIS DESCRIBES …
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The Role Of Crebh In Hepatic Energy Regulation Under Metabolic Stress
… alpha (PPARA) to regulate expression of the genes involved in lipolysis, FA oxidation, and ketogenesis by activating fibroblast growth factor 21 (FGF21), a hepatic hormone that regulates whole-body energy homeostasis. Gain- and loss-of-function analyses indicated that CREBH and PPARA regulate …
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Tuberculosis and genes of the IL12/IL23/IFNγ pathway: Exploring functional significance of novel mutations in the IL12p40 promoter
The aim of this work was to screen the IL12p40 gene promoter for association with TB disease. Initially a subcohort of children (TB cases and healthy controls) from a TB-endemic area was screened for DNA changes by the WAVE method. Thereafter, the entire paediatric cohort and a cohort of healthy …
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Regulation of skeletal muscle glucose transporter 4 expression in fructose-fed exercised rats
… factor to its binding domain on the Glut4 gene promoter, the impact of fructose consumption on this interaction has not been studied. Moreover, there is no direct evidence that an increase in MEF2 binding is due to increased accessibility of the MEF2 binding domain to transcription factors. …
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Investigation of genetic and epigenetic mechanisms of iNOS gene expression in infection of natural populations of Apodemus sylvaticus with the parasite Toxoplasma gondii
… Laboratory studies have shown that the host gene iNOS influences sensitivity and resistance to T. gondii infection. This study sets out to investigate the role of genetic and epigenetic mechanisms of iNOS gene expression in the outcome of infection of natural populations of Apodemus …
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Molecular regulation of the cardiac-enriched acetyl-CoA carboxylase isoform (ACCβ) : a novel target for therapeutic interventions in cardiovascular disease
… transcriptional regulation of numerous metabolic genes. However, transcriptional mechanisms directing the gene expression of the cardiac isoform of acetyl-CoA carboxylase (ACCβ) are less well understood. Previously, four E-box (CANNTG) sequence motifs were identified on the human ACCβ promoter. …
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Clinical and pathological characterization of a novel transgenic animal model of diabetes mellitus expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPR dn)
… recently been shown to be involved in the pathogenesis of diabetes mellitus in humans and animals models of diabetes mellitus. The aim of this study was to characterize a novel transgenic mouse model expressing a dominant negative glucosedependent insulinotropic polypeptide receptor (GIPRdn) …
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DNA methylation detection using an engineered methyl-CpG-binding protein
… evaluate the methylation status of the MGMT gene promoter to determine the best course of treatment for patients with glioblastoma. However, improved methylation detection techniques are required in order to expand the availability of such testing to more patients. Methyl-CpG-binding domain …
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