Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 183 for “"Gene products"”.
-
Characterisation of trimethoprim resistance transposons and their gene products
… different plasmid/transposon mediated resistance genes. One gene, mobilised by RP4, was located on a 4 - 6 kb transposon designated Tn4135, and resulted in the mediation of transferable high level trimethoprim resistance of greater than 1000 ug/ml. Biochemical investigation of the transposon gene …
-
Characterization of Murine Cytomegalovirus m142 and m143 Essential Gene Products
… opportunity to study the role of various viral products in replication and pathology in the natural host. Successful replication of CMV in the host depends upon the expression of a cascade of viral genes: immediate early (IE), early (E), and late (L). To date only three MCMV IE proteins have …
-
Study of Receptor Binding and Growth Effect of Gastrin Gene Products
… reports have shown the trophic effect of gastrin gene products on carcinoma cells, especially colonic cancer cells. The C-terminal tetrapeptide of gastrin, shared with Cholecystokinin (CCK), is the minimal sequence required for its biological effect through the CCK2 receptor. Structure-functional …
-
Evolution of vesicular transport in kinetoplastids: dynamics and novel gene products
The membrane trafficking system mediates delivery of macromolecules and metabolites to discrete intracellular compartments from their site of uptake or synthesis. For many pathogens the trafficking system has a special relevance as it is responsible for maintaining the host-pathogen interface, …
-
The effect of potential anticancer gene products on breast cancer cell lines
Cellular or viral delivery of anti-cancer gene therapeutics typically has been investigated as single agents. More recently combinatorial agents have been investigated for which some combinations have shown synergism. The present study was designed to evaluate three different potential anticancer …
-
Interactions Among Murine Cytomegalovirus US22 Family Gene Products That Influence Viral Pathogenesis
… are the key target cell type involved in pathogenesis, which is most effectively studied using the murine model of CMV infection. Previously three murine CMV (MCMV) genes (M139, M140, and M141) were identified to regulate viral expression in cultured macrophages and in mice. These genes are …
-
Regulation of E. coli SOS mutagenesis by dimeric intrinsically disordered umuD gene products
Products of the umuD gene in E. coli are involved in regulating the timing of error-free DNA repair processes and mutagenic translesion DNA synthesis (TLS) during the SOS response to DNA damage. Homodimeric UmuD2 is upregulated early during the SOS response, and a slow post-translational …
-
Studies on Thiobacillus ferrooxidans ATCC 33020 ATP genes and gene products, using Escherichia coli
An atp gene cluster from the extreme acidophile Thiobacillus ferrooxidans ATCC 33020 was cloned by complementation of Escherichia coli unc mutants. Eight different E. coli unc mutants were screened with T. ferrooxidans ATCC 33020 pEcoR251 plasmid and pHC79 cosmid gene banks. The ability of the …
-
Contributions of viral and cellular gene products to the pathogenesis and prognosis of aggressive lymphomas
… feature is that they are functionally heterogeneous and therefore have different biological and molecular signatures which make it difficult for all groups to respond to same line of treatment. Based on the above, I set out to look at the impact of viral and cellular gene products on these …
-
Identification and Classification of Novel Gene Products Involved in Development and Regeneration in Xenopus Laevis
… to characterize new molecular events in lens regeneration. Most of these genes are also expressed during lens development, illustrating the similarity between mechanisms of development and regeneration. A subset of genes; whose expression is up-regulated or initiated early during multiple …
-
Identification and Characterization of Helper Phage Gene Products Involved in Mobilization of Staphylococcal Pathogenicity Island SaPI1
… of staphylococcal phage 80α. The amplified genetic element is subsequently encapsidated and transduced at very high frequency. Previous studies have demonstrated that the transducing particles have virions with tails that appear identical to those of helper phage 80α but have smaller …
-
Cloning of the Genes for Colicin v Production and Immunity and Identification of the Gene Products
The genes for colicin V production and immunity from pColVB188 have been cloned into the amplifiable vectors pMB9, pBR322, pMK16, and into the bacteriophage M13mp8. The genes are closely linked and can be isolated on a deoxyribonucleic acid fragment of about 900 base pairs. The use of the …
-
Regulation of the glpFK operon of Escherichia coli K-12 and characterization of it gene products
The glpF gene, which encodes a cytoplasmic membrane protein that facilitates the diffusion of glycerol into the cell, and the glpK gene, which encodes glycerol kinase, map near minute 88 on the linkage map of Escherichia coli K-12. In the present work, the nucleotide sequence of the 843 base Pair …
-
Molecular studies of the sdaA and sdaB genes and their gene products in Escherichia coli K-12
… the structure of L-SD#1 is coded by the sdaA gene, which has been cloned and sequenced. The entire sdaA gene was fused to the lacZ gene by mutating the stop-codon of sdaA and ligating in-frame to lacZ. The fused gene directed the formation of a large protein showing both L-SD and …
-
Structural Analysis of the TOL pDK1 xylGFJQK Region and Partial Characterization of the xylF and xylG Gene Products
… and xylK (1047 bp), encoding predicted protein products of 51.6, 31.3, 27.8, 32.8, and 36.6 kDa in size, respectively. The average G+C content of the xylLTEGFJQK region was 65.7%, somewhat higher than the 58.9% seen in the immediately upstream xylXYZ region and substantially more than the 50% …
-
Isolation and partial characterization of cDNAs encoding polypeptides that interact with the capB gene products of Dictyostelium discoideum
The gene products of capB, p34 and p31, were previously isolated by co-purification with the cAMP binding protein CABP1 encoded by the capB homolog capA. The GAL4 two-hybrid system was used to screen a Dictyostelium discoideum cDNA expression library to identify proteins that interacted with …
-
The classification of gene products in the molecular biology domain: Realism, objectivity, and the limitations of the Gene Ontology
… across database resources. One such tool is the Gene Ontology (GO), a classification designed to act as a universal index for gene products from any species. The Gene Ontology is used extensively in annotating gene products and analysing gene expression data, yet very little research exists from …
-
Studies on the structure and function of various nif and nif- associated gene products encoded within the Azotobacter vinelandii nif gene cluster
… of nitrogenase from Azotobacter vinelandii. A gene replacement strategy was developed for oligonucleotide-directed mutagenesis of these proteins and the resulting biological and biochemical effects of these changes were examined. Identification of structurally important regions in the MoFe …
-
Characterization of the genes and gene products of the acetate-activating enzymes and a novel iron-sulfur flavoprotein from Methanosarcina thermophila strain TM-1
The genes encoding the acetate kinase and phosphotransacetylase enzymes from <i>Methanosarcina thermophila</i> were isolated from a genomic library on a fifteen kilobase fragment The genes are located adjacent to one another, with the phosphotransacetylase gene (<i>pta</i>) directly upstream of the …
-
Expression, Cloning, and Sequencing of Putative Insulin Signaling Genes Involved in Diapause in the Flesh Fly <em>Sarcophaga crassipalpis</em>.
… diapause and aging programs have a common set of gene expression pathways via insulin signaling. Analysis of a heterologous microarray indicated that two genes involved in the insulin pathway were down regulated during diapause. Both of these genes, Pi3K68d and Pde6, along with the Insulin …
Page 1 of 10