Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Gene prioritization"”.
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Gene prioritization through hybrid distance-score rank aggregation
… developing novel rank aggregation methods for gene prioritization. Gene prioritization refers to a family of computational techniques for inferring disease genes through a set of training genes and carefully chosen similarity criteria. Test genes are scored based on their average similarity to …
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Causal Gene Prioritization Across Diverse Diseases Through Multi-Omic Data Integration
… loci, yet the underlying causal variants, genes and tissues of action are unknown for most of the reported associations. This limits our biological understanding of the mechanisms underlying diseases and presents a major bottleneck for experimental follow up and clinical translation of the …
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A novel weighted rank aggregation algorithm with applications in gene prioritization
… of the aggregation method on a set of test genes pertaining to the Bardet-Biedl syndrome, schizophrenia, and HIV and show that the combinatorial method matches or outperforms state-of-the art algorithms such as ToppGene.
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Algorithms for discovering disease genes by integrating 'omics data
… “-omic” data, including genomic sequences, gene expression, and molecular interactions. Genome Wide Association Studies (GWAS) compare genomic sequences from healthy and affected populations to identify genetic variants that are potentially associated with diseases. Monitoring of gene …
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Integrative analysis of heterogeneous genomic datasets to discover genetic etiology of autism spectrum disorders
Understanding the genetic background of complex diseases is crucial to medical research, with implications to diagnosis, treatment and drug development. As molecular approaches to this challenge are time consuming and costly, computational approaches offer an efficient alternative. Such approaches …