Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"Gene polymorphism"”.
-
Studies on the angiotensin converting enzyme gene polymorphism and Ace inhibitors
… step in the control of blood pressure. The gene encoding for ACE is subject to an insertion/deletion (I/D) polymorphism which is associated with different levels of the enzyme in serum. This polymorphism accounts for 47% of the variability in serum ACE concentrations between subjects but its …
-
Association of Interleukin-12 gene polymorphism with Hepatitis B virus persistnece and Hepatocelluar carcinoma
… host immune factors including single nucleotide polymorphisms(SNPs), and cytokines play a crucial role in host immune defense. This study was undertaken to investigate the association between HBV persistence and development of hepatocelluar carcinoma(HCC) and SNPs of interleukin(IL)-12A. METHODS: …
-
The association between interleukin-1 gene polymorphism and periodontitis in adults in Africa: A systematic review
… Research suggests that variations within the genes coding for IL-1 i.e. (polymorphisms) can influence an individual's susceptibility to periodontitis. This systematic review aimed to identify, appraise, and synthesize the best evidence for the association between IL-1 gene polymorphism and …
-
Importance of cardiac reserve for evaluation and prediction of cardiac function and morbidity assessed by low-dose dobutamine stress echocardiography
… disease and to evaluate b1-adrenoceptor (AR) gene polymorphism (Ser49Gly). Studies were performed in patients with dilated cardiomyopathy, in rats (young, healthy, diabetic and hypertensive), in mice (immunized against the β1AR) and in heart-transplanted patients. The cardiac reserve was …
-
The Maintenance of Genetic Variation by Environmental Selection
… has been a major task of biologists. Genetic variation plays a major role in the creation of biodiversity because in contrast to environmental influence, genetic variants can be inherited. For a species in natural environments, genetic variation is generated by mutation, eliminated by …
-
Untersuchung von cosmc-Mutationen bei Patienten mit IgA-Nephropathie
… IgA1 galactosylation is involved in the pathogenesis of IgA nephropathy (IgAN), the most common glomerulonephritis in the world. The galactosyltransferase core-1 beta3-galactosyltransferase-1 (C1GALT1) and its chaperone cosmc are specifically required for O-galactosylation of the IgA1 hinge …
-
La percezione del gusto amaro nell’uomo: la sensibilità gustativa al 6-n-propiltiouracile (PROP) come marker della variabilità individuale con implicazioni fisiologico-nutrizionali
… It is associated with the bitter receptor gene (TAS2R38) and with differences in the salivary proteins involved in taste function. Among them, the enzyme Zn dependent gustin, a trophic factor of taste buds. We investigated the possible association of PROP taste phenotype with TAS2R38 …
-
C-Reactive Protein Polymorphism and Serum Levels as an Independent Risk Factor in Sickle Cell Disease
… the relationship of a dinucleotide repeat polymorphism in the intron of the CRP gene and serum CRP levels as independent risk factors for end-organ dysfunction (mild vs. severe) in adults with sickle cell disease. The pathogenesis of secondary complications of sickle cell disease is complex …
-
Freud-1, a novel regulator of the dopamine D2 and serotonin 1A receptor genes
… factors that regulate the expression of neuronal genes remain incompletely understood. The focus of my research has been on the function a novel helix-loop-helix transcription factor, Freud-1, which is implicated in the regulation of the 5-HT1A receptor and is genetically linked to non-syndromic …
-
The human Deleted in Azoospermia gene family : structure, function and evolution
The human Deleted in Azoospermia genes lie within the AZFc region of the Y chromosome that is frequently deleted in men with severe spermatogenic failure and male infertility. This thesis describes the evolution, structure and function of human DAZ genes. First, we determined that Y-linked DAZ …
-
Significant Association of IL-18 Genetic Polymorphisms with Aspirin-Intolerant Urticaria in a Korean Population
… after aspirin ingestion. Although the pathogenesis of AIU has not been fully understood, mast cell activation and neutrophil infiltration have been suggested to be involved. Interleukin-18 (IL-18) can stimulate mast cells and then release inflammatory mediators such as IL-4, IL-13 by …
-
Vulnerability to substance dependence
… current studies was to examine associations with genetic variation, impulsive sensation seeking (ImpSS) and responsiveness to substance-related stimuli among four hundred individuals (100 alcoholics, 100 heroin abusers, 100 smokers and 100 controls), who each completed questionnaires measuring …
-
Prediction and Detection of Hypoglycaemia in Type 1 Diabetes
… I then examined whether individual genetic factors might contribute to risk of persistent severe hypoglycaemia, exploring the association between polymorphisms in Angiotensin Converting Enzyme ACE gene and severe hypoglycaemia in 77 participants in HypoCOMPaSS study. Interestingly, I …
-
A Study of the Molecular Immunogenetics of Type 1 Diabetes in Man
… β cells. There is increasing evidence that genes outside the MHC region contribute to the pathogenesis of type 1 diabetes. Cytokines due to their role in immune regulation seem to play a crucial role in the pathogenesis of the disease. Three hundred and eight patients with type 1 diabetes …
-
Polimorfisme gen apolipoprotein E pada pasien infark miokard akut (IMA) di Rumah Sakit dr. Saiful Anwar Malang
… ini bertujuan untuk mengetahui variasi genetik (polimorfisme) gen Apo E pada pasien IMA di Rumah Sakit dr. Saiful Anwar Malang. Sample darah diambil dari 10 pasien IMA dipilih sesuai dengan kriteria inklusi dan eksklusi. Kemudian dilakukan isolasi DNA menggunakan Geneaid DNA Ekstraction …
-
Sensitivity to chemical stimuli plays a fundamental role in the food preferences. Examples in the evolutionary scale: 1. Role of the walking leg chemoreceptors in the red swamp crayfish Procambarus Clarkii 2. PROP bitter taste sensitivity and its nutritional implications in Humans
… that may contribute to differences in the genetic predisposition to taste PROP and identify confounding variables which may explain the controversial data in the literature about the relationship between PROP taste sensitivity and BMI. 1) We investigated the possible relationship between …
-
Östrogenrezeptor-Gen-Varianten bei Patienten mit Panikstörung
… der Menopause ein, was einen Einfluss von Östrogenen oder Östrogenrezeptoren (ESR) nahe legt. Die vorliegende Arbeit befasst sich mit der Rolle von Östrogenrezeptor α und β (ESRα and β) Genvarianten bei Panikpatienten. Hauptziele waren die Aktualisierung der genomischen Organisation der ESR …
-
Cytochrome P450 1B1 and 12/15 Lipoxygenase Interaction in Paraventricular Nucleus in Angiotensin II-induced Hypertension in Females
… is metabolized by 12/15-lipoxygenase (ALOX15) generating 12(S)- and 15(S)-hydroxyeicosatetraenoic acid (HETE) which have been implicated in cardiovascular and renal diseases. This study was conducted to investigate a) the contribution of ALOX15 to Ang II-induced hypertension and associated …
-
Implication of homocysteine, resistin and vitamin D in development of type 2 diabetes
… was suggested to play a role in the pathogenesis of T2DM. Increased levels of resistin have been linked with adiposity/inflammation and insulin resistance in T2DM patients. Vitamin D deficiency is another global problem and elevated levels of blood glucose and vitamin D deficiency have …
Page 1 of 2