Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Gene pathway"”.
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Graph Attention Mechanisms for Modeling Pathway-Level Importance from Gene Expression
… revolutionized the analysis and profiling of gene expression data, enabling a comprehensive understanding of the complex mechanisms underlying molecular biology. However, the high dimensionality and noise inherent in gene expression data pose significant challenges for biomarker discovery and …
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Gene switches and their applications in eukaryotic systems
Gene switches, also known as transcription factors, are important components of genetic circuits, and they have wide utility in synthetic biology, gene therapy, and developmental biology. Small molecule inducible gene switches are especially valuable as they offer an easy way to regulate target …
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Rational Engineering of Expression Level of Multi-Gene Systems encoding Natural Product Biosynthesis in Streptomyces
… harbor unprecedented numbers of biosynthetic gene clusters (BGCs) potentially encoding novel compounds. However, cloning and controlled expression of these large BGCs in a heterologous host require tedious optimization on a case-by-case basis. This dissertation presents a synthetic biology …
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Sparse group sufficient dimension reduction and covariance cumulative slicing estimation
… immediate application of our method is to the gene pathway data analysis where genes naturally fall into groups (pathways). An analysis of a glioblastoma microarray data is included for illustration of our method. In Part Two, for many-valued or continuous Y , the standard practice of replacing …
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Drosophila Nicotinamidase And Sir2 In Longevity Regulation And Oxidative Stress Response, And The Implications For Aging Theory
… Evidence is mounting, however, that many genetic manipulations that promote resistance to oxidative stress do not correlate with an increase in lifespan. Furthermore, many biochemical and genetic pathways involved in lifespan regulation do not have any known role in oxidative stress …
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Developing synthetic, minimal promoters in Saccharomyces cerevisiae
… DNA insertions to express a heterologous multi-gene pathway. Furthermore, their high sequence homology provides the organism the opportunity to perform homologous recombination resulting in undesirable gene deletions. For these reasons, there is a critical demand for short promoters with low …
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Cellular reprogramming in eukaryotes
… processes are controlled by a highly complex genetic and epigenetic network. Although much of this complexity is still unknown to us, we have nonetheless begun exploring, perturbing, and creating genetic circuits in cells. To truly understand and control a cell, we have to build it from …
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Computational methods for personalized cancer genomics
… based on potentially clinically relevant driver genes, each with unique defining target features and pathways. These subtypes correspond to and build upon our previous knowledge of breast cancer subtypes. We also identify disease mechanisms in identifying key novel cancer pathways in which driver …