Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 85 for “"Gene networks"”.
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Feedback regulation in gene networks
Cellular genetic information is encoded in DNA. The passage of this information from DNA to proteins is regulated at multiple levels and each level gives cells the chance to control the structure and function of their components. Transcriptional regulation is an important part of this multi-level …
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Functional modularity in gene networks
… aide the analysis and design of multi-module genetic systems. These tools are a result of combining mathematical modeling and theoretical analysis with experiments performed in Escherichia coli. While current approaches most often neglect to account for context-dependence in living systems, …
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Cortisol responsive gene networks in cardiovascular disease
… CORtisol NETwork (CORNET) consortium identified genetic variants, spanning the SERPINA6/SERPINA1 locus on chromosome 14, associated with morning plasma cortisol and shown to be causal for ischaemic heart disease. SERPINA6 encodes Corticosteroid Binding Globulin (CBG), responsible for binding most …
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Impact of Stochastic Transcriptional Delay on Gene Networks
… way to account for these reactions in models of gene regulatory networks is to incorporate dynamical delay. The stochastic nature of the reactions necessary to produce protein leads to a waiting time that is randomly distributed, complicating simulation and analysis. We examine this problem using …
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Modeling and Validation of Gene Networks in Breast and Pancreatic Cancer
… pipeline to discover alcohol-regulated metabolic genes associated with oncogenic calcium signaling. The role calcium signaling in cancer promoting actions of alcohol was validated experimentally and the clinical relevance of these genes was established by their expression profiles in publicly …
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Exploring flowering gene networks in soybean and arabidopsis through transcriptome analysis
… of this thesis was to explore the flowering gene networks in soybean through an RNASeq based transcriptome analysis. Chapter One discusses the effect of three photoperiod treatments, short day (SD), long day (LD) and shift from 3 weeks LD to 1 week SD on six domesticated varieties of Glycine …
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Progesterone Receptor Regulation of the Gene Networks That Control Ovulation in Mice
… PR-null mice, my research has uncovered novel gene networks, which act downstream of PR to control ovulation. Most notably, my study has identified several factors such as the peroxisome proliferator-activator receptor gamma (PPARgamma), hypoxia-inducible factors (HIFs), and interleukin-6 …
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GENETIC DISSECTION OF MATURITY DATE IN PEACH AND APRICOT REVEAL A ROLE FOR CONSERVED GENE NETWORKS
… by multiple factors, both environmental and genetical, being of notewhorthy importance and impact in the orchard management activities. Nevertheless MD is characterized by a high variability, having cultivated varieties classified from very early to ultra-late ripening. Dissection of the …
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Leveraging biological pathways and gene networks to understand the genetic architecture of diseases and complex traits
… highlighted the role of biological pathways and gene networks in disease biology. In this thesis, we formally assess (1) the contribution of disease-associated gene pathways to disease heritability, (2) the contribution of genes with high network connectivity in known gene networks to disease …
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Spatial organisation of the immunoglobulin heavy chain locus and inter-chromosomal gene networks driving B cell development
… Igl) loci. The mouse Igh is a large (~3Mb) multigene locus that contains 195 variable (V), 10 diversity (D) and 4 joining (J) genes that undergo developmentally regulated V(D)J recombination to produce the variable region of the antibody. Gene expression depends on spatial organisation of …
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Hepatic gene networks due to the trans-10, cis-12-conjugated linoleic acid supplementation in growing male mice
… trans-10, cis-12-CLA supplementation on hepatic gene expression in growing male mice by measuring mRNA abundance of thirty-eight genes encoding important enzymes, ligand-dependent nuclear receptors, transcription regulators and transporters in lipid metabolism. Feeding growing male mice diets …
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Identification And Characterization Of The Major Gene Ma And Its Associated Co-Expression Gene Networks Regulating Apple Fruit Acidity
… study attempts to identify and characterize the gene underpinning Ma and its associated co-expression gene networks. To achieve the goal, three sets of experiments were conducted. The first set of experiments was designed to identify the candidate gene for Ma and was summarized in Chapter 1. This …
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Coordinated regulation of the flagellar, Salmonella pathogenicity island 1, and the type I fimbriae gene networks in Salmonella typhimurium
… This decision process is governed by large genetic networks that process the information leading to a phenotypic response from the cell. Using the food-borne pathogen, Salmonella, as a model organism, we try to investigate how cells encode strategies in networks to optimally control cellular …
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Longitudinal gene networks, canonical pathways and functional analysis of microarray data from Longissimus thoracis et lumborum muscle samples of early-weaned Angus steers
… relies partly on transcriptional control of gene networks as a long-term mechanism affecting the level of expression of several key enzymes. Objectives were to evaluate temporal gene expression profiles in Longissimus thoracis et lumborum of early-weaned (155 +/- 10 d age at weaning) Angus …
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Simulation and identification of gene regulatory networks
Gene regulatory networks are a well-established model to represent the functioning, at gene level, of utterly elaborated biological networks. Studying and understanding such models of gene communication might enable researchers to rightly address costly laboratory experiments, e.g. by selecting a …
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Identification of glucocorticoid-regulated genes and inferring their network focused on the glucocorticoid receptor in childhood leukaemia, based on microarray data and pathway databases
… there are many controversial hypotheses about genes regulated by GCs and their gene networks. In particular, two main issues are investigated: (i) GC-regulated genes and (ii) the glucocorticoid receptor (GR) gene networks. Only few overlapping genes have been reported from previous studies. …
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Synthetic biological circuits for continuous signal processing
Natural organisms evolved gene networks that measure continuous environmental information and adjust gene expression to maximize fitness. Engineered cells will need to be capable of similar signal processing and computation in order to operate efficaciously in complex environments, like the human …
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Minimizing interference due to genetic manipulation
Synthetic gene networks are the functional genetic 'programs' that will form the basis of increasingly sophisticated engineered organisms, cells and tissues. Important factors to consider in biologically engineering circuits are modularity and orthogonality of the components. We explore these …
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Development and evaluation of machine learning algorithms for biomedical applications
Gene network inference and drug response prediction are two important problems in computational biomedicine. The former helps scientists better understand the functional elements and regulatory circuits of cells. The latter helps a physician gain full understanding of the effective treatment on …
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