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Showing 1 to 20 of 117 for “"Gene expression regulation"”.
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RNA sequencing for the study of gene expression regulation
… of functional cell products is known as gene expression. In recent years, sequencing of RNA (RNA-seq) has emerged as the preferred technology for the simultaneous measurement of transcript sequences and their abundance. The analysis of RNA-seq data presents novel challenges and many …
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Computational Analysis of Gene Expression Regulation from Cross Species Comparison to Single Cell Resolution
Gene expression regulation is dynamic and specific to various factors such as developmental stages, environmental conditions, and stimulation of pathogens. Nowadays, a tremendous amount of transcriptome data sets are available from diverse species. This trend enables us to perform comparative …
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Zinc Finger Protein 36L1 (ZFP36L1): Gene Expression, Regulation and Interactions with Immune Receptors in Human Tumour Cells.
… in the differentiation, proliferation, and angiogenesis of various cell types. ZFP36L1 can positively or negatively regulate cellular processes such as transcription and signalling, depending on external and internal stimulations. The basic mechanism with which this protein functions is via its …
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Analysis of gene expression, regulation and function of three symbiotic ABC subfamily-B transporters in Medicago truncatula
… pathway comprising a core set of around seven genes common to both symbioses, central to which is the calcium calmodulin kinase, CCaMK. Here I describe the identification and characterization of three novel M. truncatula ATPBinding cassette containing sub-family B transporters, …
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Pseudorabies Virus Latency Associated Transcript Gene: Expression, Regulation, and Role in the Establishment of Latency in Swine
… the PrV latency associated transcripts (LAT) gene is also active during an in vitro productive infection. Three polyadenylated [poly(A)] RNAs (about 1.0, 2.0, and 8.0 kb) made during a lytic in vitroinfection share similar physical properties with the in vivo LATs. The 1.0 and 8.0 kb RNAs …
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Computational Approaches to Predict Effect of Epigenetic Modifications on Transcriptional Regulation of Gene Expression
… infer protein-DNA bindings in the presence of epigenetic modifications. Epigenetic modifications are alterations to the DNA resulting in gene expression regulation where the structure of the DNA remains unaltered. It is a heritable and reversible modification and often involves addition or …
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Genetic regulation of maize floral development - insights from the transcriptome and translatome
… Floral development in plants is regulated by gene expression. Understanding gene expression regulation in maize floral development is critical to regulate floret fertility in other grasses and potentially useful to engineer more productive cereal crops. In this work, I focus on gene expression …
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TOWARDS AN UNDERSTANDING OF GENETIC SELECTION IN BREAST CANCER
… genomes accumulate chromosomal abnormalities and gene mutations but must maintain the ability to survive in vitro. We sought evidence in breast cancer that genetic selection acts to maintain tumour survival. Analysis of genomes from 243 breast tumours revealed 766 unstable and 812 stable …
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A bright, sweet evolution: a molecular genetic analysis of Calvin cycle gene expression response to light and sugar in the liverwort marchantia polymorpha, and insights into Calvin cycle promoter motif enrichment in land plants
… given their ease of use in the laboratory. The expression of CBB genes in higher plants is well known to be regulated by light, sugar and plant development, yet no focus has been given to lower plant CBB gene expression regulation. Marchantia polymorpha, a bryophyte in the Marchantiphyta …
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Identification of common and unique stress responsive genes of Arabidopsis thaliana under different abiotic stress through RNA-Seq meta-analysis
… read mapping, read counting and differential expression analyses for RNA-Seq data. We found that 5729 and 5062 genes are induced or repressed by only one type of abiotic stresses. There are only 18 and 12 genes that are induced or repressed by all stresses. The commonly induced genes are …
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Twist of messenger Fate: novel mechanisms for TDP43 in modulating mRNA decay and alternative polyadenylation
… and cytoplasmic accumulation, driving neuronal degeneration. The same phenotype is present in patients bearing ALS-inducing mutations in other genes and ALS sporadic patients, defining TDP43 proteinopathy as a common feature in this pathology. Why does it cause specific motor neuron death? Our …
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Role of m<sup>6</sup>A RNA "reader" YTHDF2 in Mammalian Germ Cells and Early Embryo Development
… of mRNA which ultimately leads to changes in gene expression. Regulation of gene expression is essential for every tissue and every organism, specifically in cell fate determination. N6-methyladenosine (m6A) is one of the most abundant and conserved internal mRNA modifications that plays …
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Paxillin is a Novel Regulator of Xenopus Oocyte Maturation
… ERK2. ERK2 then acts back on MOS to enhance its expression resulting in amplification of the kinase signaling cascade. To date, little is known regarding other factors that regulate this powerful feedback kinase cascade. Here we present the scaffolding molecule, Paxillin, as a newly recognized …
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Sex Differences and the Evolution of Gene Expression
… I focus on sex differences and the evolution of gene expression in three parts. First, I examine the evolutionary properties of genes with sex differences in mean expression levels in the Drosophila brain – a surprisingly understudied organ in this context. Second, I identify and characterize …
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Regulation of INTS-6 by post-translational modifications: exploring phosphorylation, SUMOylation and their biological relevance in Caenorhabditis elegans
… such as development, DNA damage response, and gene expression regulation. In this context and in line with the group's research efforts, the overall objective of this thesis is to study subunit 6 of the Integrator complex (INTS-6), with a particular focus on its role in pathological contexts, …
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Computational methods for inferring regulatory mechanisms from sequence and expression variation
… of sequencing technologies, more and more novel genetic variants are being detected. Numerous human genetic and bioinformatic studies associate genotype data to phenotype information and provide increasing number of phenotype-related variants. Despite the large number of associations been …
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New mechanisms in transcription regulation and chromosome organization in Caulobacter crescentus
… of these proteins can also profoundly affect gene expression regulation. In this work, I have characterized two DNA-binding proteins from the bacterium Caulobacter crescentus; one transcription factor, GcrA, and one NAP, CnpA. First, I found that GcrA, an essential cell-cycle regulator in …
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Transcriptional and Translational Regulation of Cardiac Progenitors in the Mouse and Zebrafish
… Hand2 in the cardiac neural crest progenitors. Generally, expression levels in vertebrates reflect the combined transcription of both alleles of the gene being transcribed. Although there are notable exceptions (i.e., X chromosome genes), the presence of only one functional copy or more than two …
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Mash1 Defines Lineage Restricted Neuronal and Oligodendrocytic Precursor Cells in Spinal Cord Development
… pro-neural function. The transient nature of its expression limits the ability to trace Mash1+ progenitors. To study the developing neural tube from progenitor to adult neuron, transgenic mouse strains were generated that express GFP, Cre recombinase, and tamoxifen-inducible Cre recombinase. The …
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Identification of alternative exon usage in cancer survival using hierarchical modeling
… exon usage (AEU) is an important component of gene expression regulation. Exon expression platforms allow the detection of associations between AEU and phenotypes such as cancer. Numerous studies have identified associations between gene expression and the brain cancer glioblastoma multiforme …
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