Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 195 for “"Gene expression profiles"”.
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Lung disease diagnosis from gene expression profiles
… from a broad range of lung diseases. We used gene expression microarray data from five different lung diseases—lung adenocarcinoma, lung squamous cell carcinoma, large cell lung carcinoma, chronic obstructive pulmonary disease, and asthma—as well as a non-diseased phenotype, to train a …
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Sex Specific Gene Expression Profiles In Fibrosis and Copd
… not entirely conserved between sexes. Modulated expression of a number of genes related to immune regulation and extracellular matrix remodeling, important events involved in IPF and COPD, have been measured in lung cells and tissues however limited investigations have probed the expression of …
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Dimensionality of Data Matrices With Applications to Gene Expression Profiles
Finally, a robust extension of the dimensionality tests is discussed, and a real example is used to demonstrate the merit of the robust alternative.
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Unique gene expression profiles of microglia and astrocytes following innate immune activation
… identifying common and unique pathways of gene expression during activation may provide new insight into the distinct roles these cells have in the CNS during infection and inflammation. In the current study, we utilized microarray analysis to examine the response of astrocyte and microglia …
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Prediction method of condition-specific protein-protein interactions using gene expression profiles
… PPIs를 정확히 이해하는데 제약점이 되고 있다. 한편, 유전자 발현 프로파일(GEP, gene expression profiles) 데이터는 여러 세포조건을 가지고 있지만 이를 이용한 조건 특이적인 PPIs 예측정도를 조사한 연구는 많지 않다. 본 연구에서는 줄기세포 및 종양세포에서 조건 특이적인 PPIs 데이터를 구축하고, 이 중 배아 줄기세포(ESC, embryonic stem cell)의 GEP 를 이용한 ESC-특이적 PPIs 예측정도를 여러 정규화 방법 (Normalization methods) 및 유전자 공동 …
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Characterization of DNA methylation and gene expression profiles in post-traumatic stress disorder
… is necessary, but not sufficient, for the pathogenesis of PTSD, and that many other pre-existing factors, including genetic background, play an influential role in determining individual response to trauma. PTSD is a complex syndrome with a great degree of heterogeneity in presentation within …
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Global Gene Expression Profiles and Proteomic Assessments in Adult Females with Obstructive Sleep Apnea Syndrome
… Both clinical characteristics and complex genetic and environmental interactions have made it difficult to understand OSAS disease etiology and identifying patients at risk is still elusive. A pattern of gene expression in cells or tissues related to a disease state for OSAS would provide …
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Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer
… hydrocarbon receptor (AhR) which activates CYP1 gene transcription. Polymorphisms in these genes affect enzyme activity and therefore BaP bioactivation.
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Detection of Novel Genomic Markers for Predicting Prognosis in Hepatocellular Carcinoma Patients by Integrative Analysis of Copy Number Aberrations and Gene Expression Profiles: Results from a Long-Term Follow-Up
… of DNA copy number aberrations (CNAs) and gene expression profiles. Array comparative genomic hybridization and expression array were performed on 45 and 31 HCC samples, respectively. To identify functionally important genes, concordant results of DNA copy number and gene expression were …
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A novel 4-valued discrete network for the analysis of signalling events integrating protein interaction and gene expression data applied on hematopoietic diefferentiation
… made with the aid of interaction databases and gene expression profiles. Starting from molecular interaction-databases complex networks are generated comprising all known cellular signalling paths. But, not all of them play a role in a specific cellular model. The specific adaptation of the …
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Identification of DNA Copy Number-Dependent Transcriptional Deregulation inHepatocellular Carcinoma (HCC)
In recent years, cancer heterogeneity, which is essentially inherent in various types ofcancer, has been of interest to the cancer genome research. Many studies using various approaches have tried to solve the conundrum of so-called cancer heterogeneity. However, even though many successes have …
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Arid1a Haploinsufficiency Initiates Neural Crest Transformation in a Mouse Model of Mycn-driven Neuroblastoma
… in the chromatin remodeler and tumor suppressor gene (TSG) ARID1A. Additional causal studies supported ARID1A’s candidacy as a putative 1p36 TSG in MYCN-driven NBL. This study aimed to causally test Arid1a loss during Mycn-driven NBL initiation through the development of a mouse model of high …
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Alendronate Alters Single Cell Gene Expression of Cortical Osteoblast Lineage Cells During Bone Loss
… bone, we were able to individually analyze their gene expression profiles using the quantitative polymerase chain reaction (qPCR). The mice used for the study were divided into 4 treatment groups, including ovariectomized mice (OVX) and sham surgical controls (SHAM), treated with or without the …
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Influence of gene expression gradients on positional information content in fly embryos
… Much previous work has focused on using the full gene expression profiles when calculating the available positional information. In an attempt to simplify the model a discretized version, where the gene expression profiles are simplified to a binary system, was proposed. Binarizing, however, …
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The Discovery and Evolutionary Analysis of Divergent Homologs Involved in Cattle Immune and Reproductive Biology
… ESTs followed by comparative, evolutionary and gene expression studies. Eight have not been identified previously. These were named: CSSMST1, CIST1, HAVCRNDP, PRP8, PRP9, PRP11, SECTM1A and SECTM1B. Nucleotide substitution analysis provided evidence for positive selection in members of the PRP …
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Inferring the properties of transcription factor regulation
… models have thus been developed to infer the genes targeted by TFs using gene expression profiles, position weight matrices modeling TF protein binding, histone modifications, and other secondary datasets. We develop a framework for scoring the potential targets of various TFs using models …
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Transcriptomic profiling of human cells destined for therapeutic applications
… MSCs are multipotent cells that have both regenerative and immunomodulatory capacity, and which are being developed for therapeutic intervention across a variety of inflammatory and immune conditions. MSCs can be isolated from various tissues, such as bone marrow, umbilical cord, and bone …
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Genexpressionsanalysen zur Charakterisierung primärer Mammatumoren im neoadjuvanten Setting
… very heterogenous disease. For several years, gene expression analysis has been studied as a useful method for routine diagnosis. It is considered to be a promising complement to established routine parameters in breast cancer characterisation for the prognosis of disease outcome and therapy …
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Drug Repurposing Using Gene Expression Data Mining
… overall cost and risk.</p> <p>Drug-perturbed gene expression profiles are powerful phenotype readouts of biological systems, and they have been widely used in drug repurposing studies. However, the existing drug-perturbed gene expression datasets are extremely noisy and the profiling is …
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The Role of Luteal Phase Fallopian Tube Epithelium in High-grade Ovarian Serous Carcinoma
… that may predispose to malignant transformation. Gene expression profiling of laser capture microdissected FTEn, FTEb and SerCa indicated that SerCa have similar molecular profiles whether of presumed ovarian or tubal origin, supporting the notion they share a common cell of origin within the FTE. …
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