Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Gene expression heterogeneity"”.
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Influenza a virus gene expression heterogeneity regulates viral superinfection potential and host innate antiviral response
… in the U.S. alone. Its genome consists of eight gene segments each encoding one or more viral proteins. The expression of all eight genes is required to initiate productive infection. Interestingly, under the single particle infection condition, most IAV particles are semi-infectious particles …
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Transcription factor antagonism regulates heterogeneity in embryonic stem cell states
Gene expression heterogeneity underlies cell states and contributes to developmental robustness. While heterogeneity can arise from stochastic transcriptional processes, the extent to which it is regulated is unclear. Here we characterize the regulatory program underlying heterogeneity in murine …
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Spatiotemporal Interaction Networks in Plant Development
… polarity, and quantitative analysis of spatial gene expression. First, we deployed genetic, in vivo imaging and computational studies to derive an auxin-initiated feedback network of transcription factors regulating the vascular patterning and stem cell differentiation in the shoot apical …
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Molecular systems analysis of a cis-encoded epigenetic switch
An ability to control the degree of heterogeneity in cellular phenotypes may be important for cell populations to survive uncertain and ever-changing environments or make cell-fate decisions in response to external stimuli. Cells may control the degree of gene expression heterogeneity and …
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Date with Destiny: Genetic and Epigenetic Factors in Cell Fate Decisions in Populations of Multipotent Stem Cells
… Stem Cells (ESCs) to self-renew, via monitoring gene expression heterogeneity of key genes. The second model focused on Neural Mesodermal Progenitors (NMPs), a bipotent cell population found in the Caudal Lateral Epiblast (CLE) of mammalian embryos, which contributes to the spinal cord and …
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Transcriptomic and proteomic dysregulation in neuropsychiatric disorders
… disruptions within different genomic elements – genes, transcripts, novel open reading frames (nORFs: unannotated ORFs in the genome with recent evidence of coding potential), and their proteins – and considered how these elements contributed to disorder development. We used a combination of …