Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 264 for “"Gene expression analysis"”.
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Gene expression analysis in breast cancer
… in breast cancer. An in-house breast cancer gene expression dataset comprising 17 normal and 104 tumour samples was analysed to identify important genes and pathways relevant to various clinical parameters. Our results identified groups of patients with similar expression profiles, the …
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Spatially mapped gene expression analysis from tissue
"Spatial gene expression analysis platforms have been widely used for a variety of applications ranging from pathogen detection to the analysis of spatial variation of an mRNA in a tissue section. Traditionally, this is accomplished by using in situ polymerase chain reaction (in situ PCR) or in …
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Convex matrix factorization for gene expression analysis
A method is proposed for gene expression analysis relying upon convex matrix factorization (CMF). In CMF, one of the matrix factors has a convexity constraint, that is, each row is nonnegative and sums to one, and hence can be interpreted as a probability distribution. This is motivated …
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Gene expression analysis of head and neck cancer development
Microarray analysis was performed on 32 head and neck keratinocytes cultures using Affymetrix U133A/B genechips. The panel of cultures included normal cells, mortal and immortal cultures of dysplastic keratinocytes and mortal and immortal cultures from carcinomas, all grown to a standard protocol. …
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Genetic and gene expression analysis of nasopharyngeal carcinoma (NPC)
… copy number changes and differential RNA expression profiles in Nasopharyngeal carcinoma (NPC). Gene expression profiles identified a large number of differentially regulated genes involved in diverse functional processes, while genetic analysis detected extensive genomic abnormalities …
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Data mining techniques for large-scale gene expression analysis
… and little expense, to evaluate the coordinated expression levels of tens of thousands of genes, evaluate hundreds of thousands of single-nucleotide polymorphisms, and sequence individual genomes. The data produced by these assays has provided the research and commercial communities with the …
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Extensible neural network software : applications in gene expression analysis
… increasingly utilized in the life sciences for analysis of large data sets. High-throughput technologies, such as gene expression microarrays, have challenged traditional statistical learning algorithms given their high dimensionality. This thesis describes GAINN, a neural network software …
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Immunoteratological Studies of Diabetic Embryopathy Using Gene Expression Analysis
… with type I diabetes. Immune defects in the pathogenesis of diabetic embryopathy have been suggested. We hypothesized that activated immune system can counteract diabetic effect and result in prevention of diabetic embryopathy. Diabetes was induced in pregnant ICR mice by streptozocin injection. …
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Chemosensory gene expression analysis in the argentine ant, linepithema humile
This experiment was conducted to determine expression patterns of a subset of chemosensory genes, including odorant receptors (Ors) and odorant binding proteins (OBPs), in the invasive Argentine ant, Linepithema humile. Fragments of two Ors were identified from a whole ant EST project, which …
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Highly Constrained Kinetic Models for Quantitative Single-Cell Gene Expression Analysis
Cells are for the most part genetically identical, and it is the gene expression which determines different cell types in the body. Transcription, the first step in gene expression, is a complex, multi-step process initiated by transcription factors (TFs) binding to DNA promoter regions, followed …
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Differential gene expression analysis of metolachlor treated human liver cells by microarray
1 PDF file (viii, 159 pages)
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Functional genomics through metabolite profiling and gene expression analysis in Arabidopsis thaliana
… is to take full advantage of the knowledge generated by the Arabidopsis thaliana genome project, and to employ state-of-the-art functional genomics techniques to assign function to each gene. This will be achieved through a complete understanding of what all cellular components do, and how …
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Skeletal element elongation and interdigital tissue regression in developing bat limbs: a gene expression analysis
… free digits. An understanding of the genes, interactions and events that shape bat limbs, will inform conventional models of development. This dissertation characterised differential expression of Meis2, in the context of interdigital regression, and the 5'HoxD genes in the context of …
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Differential gene expression analysis reveals functional roles of cryptic orange-pigmented organ in the colorless head kidney of Antarctic icefishes
… in Antarctic fishes or teleost fishes in general. To assess the tissue type and functions of this cryptic orange body, we performed RNA sequencing and analyzed the orange body transcriptome relative to the surrounding head kidney tissue. We found 5,263 differentially expressed genes in the …
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Human Embryonic Stem Cells - Constitutive Gene Expression and Differentiation Towards Definitive Endoderm and Posterior Foregut Endoderm
… types, presumably also beta cells. In order to generate therapeutically relevant beta cells, the scientific community focuses on recapitulating the embryonic processes behind beta cell development. In order to develop protocols that direct differentiation of hESCs along the developmental program …
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Contributions to Statistical Problems Related to Microarray Data
… is a high throughput technology to measure the gene expression. Analysis of microarray data brings many interesting and challenging problems. This thesis consists three studies related to microarray data. First, we propose a Bayesian model for microarray data and use Bayes Factors to identify …
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Characterizing physiological and genetic differences in the early immune response to Haemonchus contortus in resistant and susceptible sheep
… may provide better targets for differential gene expression analysis and eventual discovery of selectable markers for parasite resistance. Antibody levels of hair ewes and composite Dorset x Finnsheep-Rambouillet wool ewes were measured during breeding and again after parturition. Results …
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Molecular Basis of Sex Differences in Cardiac Hypertrophy and Heart Failure
… is at least in part mediated by differential expression of TGFβ family members. To test this hypothesis, we utilized an angiotensin II pump infusion rodent model of cardiac hypertrophy in both male and female mice, followed by gene expression analysis and gene expression analysis of …
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Hormones, Simulated Microgravity and Hypergravity affect Bone and other Physiological Systems in Zebrafish Larvae
… rerio) are increasingly used for physiological, genetic and developmental studies. Understanding the consequences of altered gravity on bone development and on general physiology in an entire organism remains to date incomplete. We used altered drug treatment and gravity experiments to evaluate …
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