Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"Gene duplications"”.
-
Functional overlap in gene duplications of the yeast Saccharomyces cerevisiae
… of DNA. The presence of extra copies of some genes can result in certain genes performing similar or identical functions as their duplicated counterparts. This study reveals phenotypes for functionally overlapping genes and classifies selected duplicated genes as functionally overlapping or …
-
Contribution of gene duplications to the evolution of genetic networks
Exploring the forces that drive evolution at the gene network level and investigating underlying principles behind this process are fundamental questions in the context of understanding how evolution shapes transcriptional circuits. In this thesis I present two different explorations along these …
-
NANOGP1 as a Model to Study the Consequences of Gene Duplications on Human Pluripotency and Development
Gene duplication events play an important role in genome evolution; they can also create developmental strategies that differ between species. However, the functional contribution of duplicated genes in early human development and pluripotency is poorly understood. To address this knowledge gap, I …
-
Correlation of HAS2-associated gene duplications with biological aggressiveness of mast cell tumors in Chinese Shar-Pei dogs
… hyaluronan, a protein associated with angiogenesis and tumor cell motility in multiple human and canine neoplasms. Cutaneous mucinosis in Shar-Pei has been associated with gene duplications upstream of the hyaluronic acid synthase 2 gene (HAS2). The objective of this study was to evaluate …
-
Gene duplication and the evolution of the higher diptera
<p>Gene duplication is an important source of evolutionary innovation. Using the publicly available genomic information, I studied lineage-specific gene duplications in <i>Drosophila melanogaster</i> (fruit fly), <i>Anopheles gambiae</i> (mosquito), <i>Tribolium castaneum</i> (red flour beetle), …
-
The evolutionary history and impact of polyploidy in mustard crops and their relatives
Gene duplications provide raw material for the emergence of novel traits. The two primary mechanisms for gene duplication are polyploidy events, which result in whole genome duplications or triplications (WGD, WGT), and small-scale duplications (SSD). Together, these processes play a crucial role …
-
Environmentally Influenced Duplication Patterns Followed by Functional Shifts Fueling the Evolution of Metazoan Sensory Systems
… environment have been extensively studied. How gene duplications have played an important role in sensory evolution by duplication followed by functional shifts resulting in neofunctionalisation has been analysed. This extensive neofunctionalisation allows for an expansion in the number of …
-
Genome reconstruction and combinatoric analyses of rearrangement evolution
… major current focus of biomedical research. Next generation sequencing technologies can be used nowadays to generate high-resolution data-sets of these alterations in cancer genomes. This project has been developed along two main lines: 1) the reconstruction of cancer aberrant karyotypes, together …
-
Landscape genomics of tropical high altitude plant species
… involve demographic processes that occur over generations and affect allele frequencies within populations, leading to patterns of genetic restructuring. The specific genetic structuring patterns that will be observed as a consequence depend on explicit geographical features, such as topography …
-
Global and chromosome-specific consequences of aneuploidy in Saccharomyces cerevisiae
… We performed high-throughput screens for genes whose deletion has a synthetic fitness cost in aneuploid Saccharomyces cerevisiae cells containing single extra chromosomes. This analysis identified genes that when deleted decrease the fitness of specific disomic strains as well as those …
-
Homeobox gene and microRNA duplication in Chelicerata
… morphological phenotypes that has probably been generated by the evolution of core development toolkit genes. The expansion of these toolkits via gene duplications is correlated with the evolution of multi-cellilarly and morphological complexity in metazoans. Small tandem duplications are a …
-
Function and evolution of seminal fluid components in Drosophila
… with lineage-specific gains, losses, and gene duplications shaping the complement of reproductive fluids. Despite this rapid turnover, conservation of functional classes is frequently seen, suggesting evolutionary constraint on fundamental reproductive processes. One such functional class …
-
Adaptive Evolution of Surface Proteins in Microbial Pathogens: Lyme Disease Pathogens (Borreliella sp.) and Human Immunodeficiency Virus Type 1 (HIV-1)
… Pathogens respond to host immune pressures with genetic changes in surface proteins through mechanisms including point mutations, recombination, gene duplication and loss, and lateral gene transfer, resulting in novel antigenic variants and antigenic diversity. This continuous adaptation helps …
-
Investigating the duplication and evolution of essential fertilization proteins
Duplication processes such as whole gene duplication and tandem domain expansion are important for the evolution and functional diversification of essential protein families. While whole gene duplications are well established sources of new genes and biological novelty, less attention has been paid …
-
COMPARATIVE GENOMICS OF CHEMOSENSORY GENE FAMILIES AMONG MEMBERS OF THE HELIOTHINAE
… of genomic tools that enable investigation into genetic mechanisms of host plant and mate recognition, and applies these tools to examine inter- and intraspecific diversity of chemosensory genes among members of the Heliothinae.In chapter 2, I produced a novel Illumina short read C. subflexa …
-
Convergent evolution of betalains in Caryophyllales
… I re-examine the phylogeny of DODA, a key gene in the betalain biosynthesis pathway, and show that the distribution of betalain-related enzyme activity is consistent with multiple origins of high activity following repeated gene duplications, consistent with inferred origins of betalains. I …
-
Phylogeny Inference in the Presence of Incomplete Lineage Sorting, Gene Duplication and Loss and Hybridization
… their most recent common ancestral species. A gene tree captures the evolutionary history of an individual gene or, more generally, non-recombining genomic region. A very complex relationship exists between the phylogeny of a set of species and the trees of genes in the genomes of those …
-
Functional and evolutionary analysis of sugar transporters in Kluyveromyces marxianus
… the sugar better than others. To understand the genetic basis that accounts for these differences, a detailed analysis of lactose utilisation was performed. The K. marxianus genome was found to encode four copies of the lactose permease (LAC12) gene, which are present in both good and poor …
-
The evolution of ribosomal protein paralogues and their roles in development
… with little to no independent influence on gene expression. However, translation is now known to be highly regulated, and growing evidence has shown that ribosomes can be heterogeneous in composition and may contribute to this regulation. In eukaryotes, cytoplasmic ribosomes consist of two …
-
Isolation and Characterization of Regulatory Peptides from Two Tetraploid Species, the Pallid Sturgeon, Scaphirhynchus albus, and the African Clawed Frog, Xenopus laevis
… an organism, results in twice the number of each gene present in the original diploid genome. Over time, the multiple copies of a single gene may accumulate different mutations and produce proteins or peptides with differences in their primary structures. The isolation of multiple forms of …
Page 1 of 2