Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Gene co-expression networks"”.
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Gene network understanding and analysis
Gene regulatory network (GRN) is a collection of regulators that interact with each other in the cell to govern the gene expression levels of mRNA and proteins. These regulators can either be DNA, RNA, protein and their complex. Transcriptional gene regulation is an important mechanisms in which an …
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THE HOST-PATHOGEN INTERACTOME AND REGULATORY NETWORKS OF ASPERGILLUS FLAVUS PATHOGENESSIS OF ZEA MAYS: RESISTANCE IN MAIZE TO ASPERGILLUS EAR ROT AND TO AFLATOXIN ACCUMULATION
… between a pathogen and its host is a complex series of events that occurs at the molecular level and is controlled by transcriptional and protein interactions. To facilitate the understanding of these mechanisms in Aspergillus flavus and Zea mays, three approaches were taken: 1) the …
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Network-based approaches towards understanding the emergence of neurodevelopmental disorders
… challenge in psychiatry. This challenge is compounded by the complexity of neurobiological organization, spanning genes to brain systems, and by the interacting influence of environmental exposures. This thesis addresses these challenges using two complementary, network-based approaches …
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Understanding compound-induced histopathology in rat liver using gene expression network methods
Current drug discovery is a lengthy and costly pipeline; it takes between twelve and fifteen years and costs $1-2 billion (USD). As such, any compound failures represent a sunk cost – exacerbated if such failures occur later in the pipeline. Compound and drug induced liver injury is a significant …
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Grapesystress: Use of systems biology and new breeding technology approaches to study water stress-resistant in grapevine plants.
… Mediterranean climates. These challenges will be compounded by heightened pest pressure and crop loss. Even though irrigation systems will expand worldwide, they will still not be sufficient to overcome the damage as the main problem is the lack of water. Therefore, the scientific community is …
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Theoretical and Algorithmic Solutions for Null models in Network Theory
… of the data-driven structure and the dynamics of complex systems is rapidly imposing as the paramount paradigm [1] across a variety of disciplines, from economics to neuroscience, with biological -omics as a major example. In this framework, the concept of Null Model borrowed from the statistical …