Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 28 for “"Gene co-expression"”.
-
THE HOST-PATHOGEN INTERACTOME AND REGULATORY NETWORKS OF ASPERGILLUS FLAVUS PATHOGENESSIS OF ZEA MAYS: RESISTANCE IN MAIZE TO ASPERGILLUS EAR ROT AND TO AFLATOXIN ACCUMULATION
… between a pathogen and its host is a complex series of events that occurs at the molecular level and is controlled by transcriptional and protein interactions. To facilitate the understanding of these mechanisms in Aspergillus flavus and Zea mays, three approaches were taken: 1) the …
-
Network-based approaches towards understanding the emergence of neurodevelopmental disorders
… challenge in psychiatry. This challenge is compounded by the complexity of neurobiological organization, spanning genes to brain systems, and by the interacting influence of environmental exposures. This thesis addresses these challenges using two complementary, network-based approaches …
-
Gene network understanding and analysis
Gene regulatory network (GRN) is a collection of regulators that interact with each other in the cell to govern the gene expression levels of mRNA and proteins. These regulators can either be DNA, RNA, protein and their complex. Transcriptional gene regulation is an important mechanisms in which an …
-
Defining a Neuroprotective Pathway for the Treatment of Ataxias
Spinocerebellar Ataxias (SCAs) are a group of genetic diseases characterized by progressive ataxia caused by neurodegeneration of specific cell types, namely Purkinje Cells (PCs) of the cerebellum. Mouse models of SCA Type 1 (SCA1) can be used to study the molecular mechanisms underlying PC …
-
Exploring flowering gene networks in soybean and arabidopsis through transcriptome analysis
… success. Flowering transition is triggered by coincidence of various external and internal cues. The overall purpose of this thesis was to explore the flowering gene networks in soybean through an RNASeq based transcriptome analysis. Chapter One discusses the effect of three photoperiod …
-
Human protein-protein interaction prediction
… methods to define the human interactome generate high quality results, but are expensive and slow. Computational methods play an important role to fill the gap.To further this goal, the prediction of human protein-protein interactions was investigated by the development of new predictive …
-
Efficient Identification and Comprehension of Molecular Pathways Associated with Irradiation Induced Hepatic Carcinogenesis
As human exploration into deep space continues to expand in the future, risk prediction for irradiation-induced diseases will become an increasingly important task. It will be critical to identify the biological effects of high-charge, high energy (HZE) and low energy 137Cs γ rays, which are the …
-
Mechanisms of defective insulin secretion in type 2 diabetes
… 2 diabetes (T2D). There is a strong hereditary component in type T2D, but the underlying pathophysiology remains largely unknown. This thesis uses a combination of gene network analysis and cell-physiological techniques to explore the genetic and cellular basis for impaired insulin secretion in …
-
The transciptomic landscape of HIV-TB
The thesis consists of four main parts. In Part 1 of this thesis I provide a broad overview of HIVTB with an emphasis on systems approaches followed by an overview of a systems-level study aiming at addressing hypotheses relating to transcriptional differences in active tuberculosis and HIV-1 …
-
A multidisciplinary investigation into the function of NFXL1
… unique to our species, are essential for communication, cognitive development, and societal function. Disorders affecting these abilities are associated with learning disabilities, reduced academic achievement, and social challenges. Despite their significance, the molecular genetic basis …
-
Characterising the Role of the Calcium-dependent Citrullinating Enzyme Peptidyl Arginine Deiminase 2 in Ovarian Cancer
… ovarian cancer (EOC) represents the fifth most common cause of cancer mortality among women worldwide and accounts for the highest fatalities amongst gynaecological malignancies. The dysregulation of calcium-dependent peptidyl arginine deiminase 2 (PADI2) plays a key role in the tumorigenesis of …
-
Prediction method of condition-specific protein-protein interactions using gene expression profiles
… PPIs를 정확히 이해하는데 제약점이 되고 있다. 한편, 유전자 발현 프로파일(GEP, gene expression profiles) 데이터는 여러 세포조건을 가지고 있지만 이를 이용한 조건 특이적인 PPIs 예측정도를 조사한 연구는 많지 않다. 본 연구에서는 줄기세포 및 종양세포에서 조건 특이적인 PPIs 데이터를 구축하고, 이 중 배아 줄기세포(ESC, embryonic stem cell)의 GEP 를 이용한 ESC-특이적 PPIs 예측정도를 여러 정규화 방법 (Normalization methods) 및 유전자 공동 …
-
Understanding factors that affect gene co-regulation patterns
… with behavior disorders and immune system can be complex and challenging. Gene expression and network analysis can help to elucidate the main molecules and pathways that influence complex traits. The goal of these studies is to understand factors that affect gene co-regulation patterns related to …
-
Understanding compound-induced histopathology in rat liver using gene expression network methods
Current drug discovery is a lengthy and costly pipeline; it takes between twelve and fifteen years and costs $1-2 billion (USD). As such, any compound failures represent a sunk cost – exacerbated if such failures occur later in the pipeline. Compound and drug induced liver injury is a significant …
-
Transcriptional variation in muscle from cattle with alternative NCAPG/LCORL QTL genotypes
The NCAPG/LCORL locus is a major QTL on bovine chromosome 6 (BTA6) that influences growth and composition in cattle. Genetic variation at this locus is associated with alterations in the developmental program of individuals throughout life that may be detected through transcriptional variation. …
-
Investigating CD8+ T-cell gene expression signatures as disease prognostic biomarkers in paediatric inflammatory bowel disease.
… tailored therapy. Previous investigation of gene expression profiles from CD8+ T-cells in adult IBD cohorts identified promising signatures, including a T-cell exhaustion signature, to predict disease outcome in these patients. Hypothesis and aim: We hypothesised that adult CD8+ T-cell …
-
Transcriptional regulation of glycosyltransferase genes in MCF-7 human breast cancer cell line following drug treatment
Bioinformatics is a subfield in computational science that is principally focused on developing methods and performing data analytics in the areas of proteomics and genomics. In this thesis I draw a link between proteomics and genomics by focusing on the regulation patterns of glycosyltransferase …
-
Evolutionary fingerprints in genome-scale networks
… evolutionary dynamics responsible for today's composition of organisms. Computer simulations either propose an evolutionary mechanism and thus reproduce a recent finding or rebuild an evolutionary process in order to learn about its mechanism. The quest for evolutionary fingerprints in …
-
Grapesystress: Use of systems biology and new breeding technology approaches to study water stress-resistant in grapevine plants.
… Mediterranean climates. These challenges will be compounded by heightened pest pressure and crop loss. Even though irrigation systems will expand worldwide, they will still not be sufficient to overcome the damage as the main problem is the lack of water. Therefore, the scientific community is …
-
Dimensionality Reduction, Feature Selection and Visualization of Biological Data
… insight. Thus, dimensionality reduction becomes an imperative pre-processing step in analyzing and visualizing high-dimensional biological data. Two major approaches to dimensionality reduction in genomic analysis and biomarker identification studies are: Feature extraction, creating new …
Page 1 of 2