Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 64 for “"Gene Network"”.
-
Gene network understanding and analysis
Gene regulatory network (GRN) is a collection of regulators that interact with each other in the cell to govern the gene expression levels of mRNA and proteins. These regulators can either be DNA, RNA, protein and their complex. Transcriptional gene regulation is an important mechanisms in which an …
-
Oxygen -Responsive Gene Network Analyses in Saccharomyces Cerevisiae
*This dissertation is a compound document (contains both a paper copy and a CD as part of the dissertation). The CD requires the following system requirements: Microsoft Office.
-
Estimation of gene network parameters from imaging cytometry data
Synthetic biology endeavors to forward engineer genetic circuits with novel function. A major inspiration for the field has been the enormous success in the engineering of digital electronic circuits over the past half century. This dissertation approaches synthetic biology from the perspective of …
-
Phenotypic variation and bistability within flagellar gene network in Salmonella Typhimurium
… enterica serovar Typhimurium, more than 50 genes divided among at least 17 operons are involved in flagellar biogenesis and chemotaxis. One of the critical features of this process is coupling of the gene expression to assembly. Like flagellar assembly, gene expression also proceeds in a …
-
Causal Gene Network Inference from Genetical Genomics Experiments via Structural Equation Modeling
The goal of this research is to construct causal gene networks for genetical genomics experiments using expression Quantitative Trait Loci (eQTL) mapping and Structural Equation Modeling (SEM). Unlike Bayesian Networks, this approach is able to construct cyclic networks, while cyclic relationships …
-
Dual functions of the retinal determination gene network member EYES ABSENT as a transcription factor and protein phosphatase
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2004.
-
Investigating the roles of candidate gap genes from the neuroblast timer series during axial patterning in the beetle Tribolium
The gap genes encode transcription factors that play a central role in the process of segment patterning in Drosophila. Specifically, they interact to form the well-characterised ‘gap gene network’, which directs the formation of segment boundaries (through regulation of pair-rule genes), and the …
-
Expression-based reverse engineering of plant transcriptional networks
Regulation of gene transcription plays a major role in mediating cellular responses and physiological behavior in all known organisms. The finding that similar genes are often regulated in a similar manner (co-regulated or "co-expressed") has directed several "guilt-by-association" approaches in …
-
Development and evaluation of machine learning algorithms for biomedical applications
Gene network inference and drug response prediction are two important problems in computational biomedicine. The former helps scientists better understand the functional elements and regulatory circuits of cells. The latter helps a physician gain full understanding of the effective treatment on …
-
Identification And Characterization Of The Major Gene Ma And Its Associated Co-Expression Gene Networks Regulating Apple Fruit Acidity
… study attempts to identify and characterize the gene underpinning Ma and its associated co-expression gene networks. To achieve the goal, three sets of experiments were conducted. The first set of experiments was designed to identify the candidate gene for Ma and was summarized in Chapter 1. This …
-
THE TRANSCRIPTIONAL PROGRAM OF GOLGI BIOGENESIS
… transcriptional contribution to Golgi biogenesis remains poorly understood because of the lack of a robust method to induce large-scale production of new Golgi units. In this study, we developed an enzyme-based approach to eliminate the Golgi apparatus, triggering the de novo formation of …
-
Unsupervised gene regulatory network inference on microarray data
Obtaining gene regulatory networks (GRNs) from expression data is a challenging and crucial task. Many computational methods and algorithms have been developed to infer gene networks for gene expression data, which are usually obtained from microarray experiments. A gene network is a method to …
-
Knowledge-fused Identification of Condition-specific Rewiring of Dependencies in Biological Networks
Gene network modeling is one of the major goals of systems biology research. Gene network modeling targets the middle layer of active biological systems that orchestrate the activities of genes and proteins. Gene network modeling can provide critical information to bridge the gap between causes and …
-
Identification of glucocorticoid-regulated genes and inferring their network focused on the glucocorticoid receptor in childhood leukaemia, based on microarray data and pathway databases
… there are many controversial hypotheses about genes regulated by GCs and their gene networks. In particular, two main issues are investigated: (i) GC-regulated genes and (ii) the glucocorticoid receptor (GR) gene networks. Only few overlapping genes have been reported from previous studies. …
-
Leveraging biological pathways and gene networks to understand the genetic architecture of diseases and complex traits
… highlighted the role of biological pathways and gene networks in disease biology. In this thesis, we formally assess (1) the contribution of disease-associated gene pathways to disease heritability, (2) the contribution of genes with high network connectivity in known gene networks to disease …
-
Myelin Gene Expression: Implications for Alcohol Abuse and Dependence
… demonstrated differential myelin-associated gene expression (MAGE) in medial prefrontal cortex (PFC) as one potential mechanism influencing acute ethanol behaviors between C57BL/6J (B6) and DBA/2J (D2) mice. Our laboratory and others have also shown MAGE is reduced in PFC of alcoholics. …
-
Transcriptional variation in muscle from cattle with alternative NCAPG/LCORL QTL genotypes
… influences growth and composition in cattle. Genetic variation at this locus is associated with alterations in the developmental program of individuals throughout life that may be detected through transcriptional variation. Here, we propose to characterize how the landscape of transcriptomes …
-
Prediction of CYP3A4 metabolic activity from whole genome RNA-seq data with feature selection machine learning methods
… project are to identify hepatically-expressed genes that are associated with CYP3A4 metabolic activity in human liver tissue and to predict CYP3A4 activity using gene expression data from whole genome RNA sequences. Due to the high-dimensionality of the dataset, we applied lasso and elastic …
-
Non-parametric algorithms for evaluating gene expression in cancer using DNA microarray technology
… been applied to medical science in order to find gene expression markers that cluster diseased and normal tissues, genes affected by treatments, and gene network interactions. All methods of microarray data analysis can be summarized as a study of differential gene expression. This study addresses …
-
Collective excitations in low dimensional systems and stochastic control of population growth in a fluctuating environment
… in condensed matter physics, noise in gene network and stochastic control in biophysics. In the first area, I construct an effective field theory to describe Bose-Einstein Condensate (BEC) realized in an external potential. This theory explicitly explores the idea of spontaneous …
Page 1 of 4