Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Gene Expressions"”.
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Cytokine Gene Expressions of Peripheral Blood Mononuclear Cells in Acute Renal Allograft Rejection
… the participation of cytokines and related gene expression in allograft rejection. Tissues from allograft biopsy were used for assessing of these gene expressions in many previous studies. However, for rejection screening, allograft biopsy is too invasive to perform without a clinical clue. …
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On information organization and information extraction for the study of gene expressions by tissue microarray technique
… and the translation of genome sequences into gene functions, leading to the identification of highly informative genes and pathways with a potential impact on understanding disease development and progression. These technologies concurrently may improve diagnostic and treatment modalities and …
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A Study of Machine Learning Approaches for Biomedical Signal Processing
… to integrating multi-omics data such as gene expressions or clinical variables. We further explore the potential application of convex analysis of mixtures, a biologically inspired latent variable modeling strategy, to missing value imputation. The preliminary results on proteomics data …
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Robust methods for analyzing multivariate responses with application to time-course data
… network by studying the relationship between gene expressions and transcription factors. The gene expressions are taken as multivariate responses in such studies. The dissertation consists of three parts. The first part develops a robust score test for linear models by a modification of the …
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Functional profiles of growth-related genes during embryogenesis and postnatal development of chicken and mouse skeletal muscle
… to measure myostatin, follistatin, activin-B gene expressions during chicken embryonic development. Strong myostatin expression was found in the early chicken embryos (E 0, E 1) and the developmental expression pattern of myostatin mRNA coincided with the periods of primary and secondary …
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Appearance Based Stage Recognition of Drosophila Embryos
… host embryo, as well as spatial information of a gene expression region is indispensable input for the discovery of the pattern of gene-gene interaction. Manual labeling of stages is becoming a bottleneck under the circumstance of high throughput embryo images. Automatic recognition based on the …
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Identifying Cancer Subtypes Using Unsupervised Deep Learning
… unknown subtypes with pathway markers of gene expressions. In order to assess the performance of R-PathCluster, we conducted experiments with several clustering methods such as k-means, hierarchical clustering, and RBM models with different input data. R-PathCluster showed the best …
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Transcriptional regulation of glycosyltransferase genes in MCF-7 human breast cancer cell line following drug treatment
… regulation patterns of glycosyltransferase (GT) genes in breast cancer cell line following the treatment with a large set of Food and Drug Administration (FDA) approved drugs. This is based on the understanding that aberrant glycosylation in breast cancer tumours stem from altered GT gene …
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The Examination of Leptin Receptors, Matrix Metalloproteinases-2 and -9 and Tissue Inhibitors of Metalloproteinases in the Rat Cervix
… upregulated in the latter part of pregnancy. The gene expressions of MMP-2 and -9 were found to fluctuate during pregnancy with up-regulation of the MMPs in the last few days of pregnancy. Additional experiments showed that MMP-2 is decreased by progesterone whereas MMP-9 activity increases and …
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Prognostic and treatment predictive factors for radio- and chemotherapy resistance in breast cancer patients- a step towards personlized medicine
… The most promising result is the gene expression profile for “radioresistance” found in a patient cohort consisting of 100 lymph node negative patients operated with breast conservation surgery and either postoperative radiotherapy or not. The samples were analyzed with …
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The Impact of Dietary Fat and Phosphatidylcholine on Increased Trimethylamine-N-oxide Levels
… rejected. Future work addressing the impact of gene expressions of enzymes on the gut and the liver is needed. The use of another high TMA containing substrates such as choline and rats is recommended.
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Interpreting Deep Learning for cell differentiation. Supervised and Unsupervised models viewed through the lens of information and perturbation theory.
… from the models, by identifying relevant genes for cell differentiation. We then continue to explore the rules and mechanisms behind the models from a theoretical perspective. Using information theory to explain the learning process and applying perturbation theory to transform the results …
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Quantile Regression Approach For Analyzing Gene Expression Data
Temporal gene expression data contains ample information to characterize gene function and is now widely used in bio-medical research. A dense temporal gene ex- pression usually shows various patterns in expression levels under dfferent biological conditions. Existing literature models the gene …
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Modeling transcriptomic dynamics and epigenomic conservation
Gene regulatory networks control gene expression during various biological processes, including two sets with similarity: differentiation processes of embryonic stem (ES) cells and embryo development processes. This thesis work centers on two aspects in analyses of such gene expression patterns: …
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BIOINFORMATICS ANALYSIS OF FULL-LENGTH RNA NANOPORE SEQUENCING AT SINGLE CELL LEVEL TO STUDY TRANSCRIPTIONAL AND MUTATIONAL PATTERNS IN HUMAN LEUKEMIA
… cells, exhibits substantial intra-tumoral heterogeneity impacting disease development, prognosis, and treatment response. However, understanding the interplay between various layers of heterogeneity at the single-cell level remains limited due to technological constraints. To address this, a …
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Microfluidic-based Tools to Investigate Gene Expression and Regulation with Tissue-specificity during Aging in Caenorhabditis elegans
… important aspect of aging research is studying gene expression and regulation. Gene expression is age-, tissue-, and individual-dependent so it is important to capture all these pieces of information. While there are pooled-sample techniques that can measure the entire transcriptome (e.g., …
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An Insight Into the Microbial Diversity and Expression of Cysteine Protease Inhibitors (Cystatin) in <i>Rickettsia parkeri</i> Infected <i>Amblyomma maculatum</i>
… based on rickettsial <em>ompA</em> gene PCR. Our results showed <em>A. maculatum </em>harbors <em>R. parkeri, R. amblyommii, </em>and <em>R. endosymbiont of A. maculatum.</em> While only <em>R. parkeri</em> was detected in female salivary glands which suggest its ability to traffic …
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Multimodal data analysis applied to a medical setting
… as cancer, have traditionally been studied using genetic data, or images alone. To understand the biology of such diseases, joint analysis of multiple data modalities could provide interesting insights. We propose the use of canonical correlation analysis (CCA) as a preliminary discovery tool for …
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Modelling biological networks : topology, dynamics and generation
… representations, both topologies and dynamics of gene regulation systems in different species and cell types were studied in this thesis. The topological structure of linear regulatory chains (LRCs) within gene regulatory networks (GRNs) were explored. Network analyses were conducted using a …
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Serotonin and Threat: from Gene to Behaviour
… implicated in anxiety revealed serotonergic gene expressions corresponding to anxiety and fear-driven behaviours. Most notably, amygdala serotonin transporter expression was positively associated with anxious behaviour and was differentiated by the serotonin transporter polymorphism. Based on …
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