Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Gene Expression Signatures"”.
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Generating Predictive Gene Expression Signatures for Alzheimer's Disease Using Postmortem Brain Tissue
… Disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-beta (Aβ) plaques and tau protein aggregates. These pathological features develop in specific brain regions, but why some areas are more vulnerable to early AD-related changes remains …
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Investigating CD8+ T-cell gene expression signatures as disease prognostic biomarkers in paediatric inflammatory bowel disease.
… tailored therapy. Previous investigation of gene expression profiles from CD8+ T-cells in adult IBD cohorts identified promising signatures, including a T-cell exhaustion signature, to predict disease outcome in these patients. Hypothesis and aim: We hypothesised that adult CD8+ T-cell …
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Characterization of The Growth Factor Receptor Network Oncogenes in Lung Cancer
… which contributes to complex lung tumor heterogeneity allowing for drug resistance development. In this study, gene expression signatures of six GFRN oncogenes overexpressed in human mammary epithelial cells (HMECs) were generated to interrogate this pathway’s downstream crosstalk, beyond …
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Gene Set Analysis of Post-Lactational Mammary Gland Involution Gene Signatures In Inflammatory and Triple Negative Breast Cancer
… involution period mimics wound healing and tumorigenesis like pathological conditions. This indicates that post-lactational involution may create the microenvironment that initiates the development of precancerous mammary cells and promotes the progression of precancerous cells into cancer cells. …
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Toward Cell-Specific Nanoparticle Delivery Systems
… predict the affinities between nanoparticles and gene expression signatures of cancer cells and (ii) optimize nanoparticle formulations for specific targets. NOCAP successfully predicts cellular affinity for previously unseen cancer cell lines. The findings demonstrate the potential of machine …
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A Systems Biology Approach to Characterizing Gene Fusion Pathways in Cancer
Gene fusions have long been known to drive cancer. Initial discovery of gene fusions was opportunistic, and functional assessment was done individually and experimentally. There is no comprehensive systems biology approach to understanding the impact of gene fusions on the signaling networks within …
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Streamlining and standardizing transcriptomic analysis in Amgen process development
… biological data; such as transcriptomic (gene expression), proteomic (protein levels), or metabolomic (metabolite levels). This thesis describes a streamlined workflow for analyzing transcriptomic data. This streamlined workflow not only reduced the barrier to conducting the analysis but …
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Postnatal specialization of astrocyte regional heterogeneity in the mammalian brain and improved tools for studying glia
… developmental trajectory of this regional heterogeneity requires further systematic study. Chapter 1 of this thesis provides a detailed literature review on the development of astrocyte regional heterogeneity. To address existing knowledge gaps, we used single-nucleus RNA sequencing to …
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Quantitative methods for linking transcriptional profiles to physiology
… this thesis focuses on the analysis of gene expression data as generated through DNA microarrays. Through the application of dimensional reduction methods such as PCA, and interactive pattern exploration, evidence for the existence of quantitative relations between gene expression …
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Temporal Regulation of LMP1 and Apoptosis Resistance After Primary EBV Infection
… in the settings of immune suppression, genetic, and/or environmental factors. While a highly successful pathogen based on prevalence, the ability of the virus to immortalize human B cells (a stage of infection thought to be critical for the establishment of latency) is quite poor. We …
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Using Tumour Evolution to Understand the Epigenetic and Transcriptional Adaptations of Cancer to Host Immunity
… system. The relevance of immunoediting in carcinogenesis, metastasis and immunotherapy resistance makes understanding the mechanisms of immunoediting essential in informing cancer therapy and prevention. Previous work on immunoediting has largely focussed on neoantigen loss, but this thesis aimed …
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Molecular pathogenesis of Helicobacter hepaticus induced liver disease
… active inflammation. We monitored hepatic global gene expression profiles and correlated them to histological liver lesions in H. hepaticus infected and control male A/JCr mice at 3 months, 6 months, and 1 year of age. We used an Affymetrix-based oligonucleotide microarray platform on the premise …
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Impact of Differentiation Status of Kidney Progenitors In Wilms Tumor Development
… that can give rise to Wilms tumors is unknown. Gene expression analysis of a large panel of Wilms tumor patients has identified different subsets of Wilms tumors that are distinct in their clinical outcomes and gene expression signatures. These subsets express specific genes that correspond to …
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Trim24 In Normal & Malignant Hematopoiesis
… treatment options include chemotherapy and allogeneic stem cell transplants, which also involves high-dose chemotherapy or radiation treatment. These options have little success in the long-run, as only an estimated 26% of patients survive five years post-diagnosis. In efforts to address this …
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Exploring the global gene expression programs and regulation in the response of quiescent human fibroblasts to distinct proliferative stimuli
… and identified a striking conservation in their gene expression signatures. However, there were specific differences among different stimuli with regard to signaling pathways that mediate these transcriptional programs. The use of a specific PI3-kinase pathway inhibitor suggested that this …
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Gene expression analysis of head and neck cancer development
… keratinocytes cultures using Affymetrix U133A/B genechips. The panel of cultures included normal cells, mortal and immortal cultures of dysplastic keratinocytes and mortal and immortal cultures from carcinomas, all grown to a standard protocol. The overall GEP revealed that many of the …
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Integrated Analysis of Molecular and Clinical Features in Melanoma Patients with Brain Metastases
… 2015 at our institution with bulk RNA-seq data generated from their MBMs. On univariate analysis, the expression of multiple immune gene signatures was associated with improved OS. The gene expression signatures of several immune cell types positively correlated with OS, except for higher …
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Machine Learning Methods for Brain Image Analysis
… of data, shortage of manpower along with heterogeneity of data following from various species all served as an added complexity to the already perplexing problem. The ability to process vast amount of brain data need to be performed automatically, yet with an accuracy close to manual human-level …
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Hypoxic gene regulation and oncogenic pathways in neuroblastoma
… patients show remarkable clinical heterogeneity, with courses ranging from spontaneous regression to fatal tumor progression despite intense multi-modal treatment. Previous studies have shown that hypoxia pushes neuroblastoma cells towards a more immature phenotype, which correlates to …
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Recognizing epigenetic patterns that mark the control of cell state in differentiation and disease
… programs during development as well as aberrant gene expression signatures in human disease is a central challenge to biology and pathology. Despite the advance of tools to chart the chromatin landscape, much is still unknown about how epigenetic signals are integrated in the transcriptional …
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