Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"Gene Expression Regulation, Developmental"”.
-
Transcriptional and Translational Regulation of Cardiac Progenitors in the Mouse and Zebrafish
… Hand2 in the cardiac neural crest progenitors. Generally, expression levels in vertebrates reflect the combined transcription of both alleles of the gene being transcribed. Although there are notable exceptions (i.e., X chromosome genes), the presence of only one functional copy or more than two …
-
Mash1 Defines Lineage Restricted Neuronal and Oligodendrocytic Precursor Cells in Spinal Cord Development
… pro-neural function. The transient nature of its expression limits the ability to trace Mash1+ progenitors. To study the developing neural tube from progenitor to adult neuron, transgenic mouse strains were generated that express GFP, Cre recombinase, and tamoxifen-inducible Cre recombinase. The …
-
Gene Regulatory Networks in Striated Muscle Pathologies
… discs. Both these tissues partake in force generation through contractile units called sarcomeres to support movement, respiration (skeletal muscle), and to pump oxygenated blood throughout the body (cardiac muscle). Gene regulatory networks, the interactions between lineage or …
-
Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance
Melanoma antigen (MAGE) genes are conserved in all eukaryotes and encode for proteins sharing a common MAGE homology domain. Although only a single MAGE gene exists in lower eukaryotes, the MAGE family rapidly expanded in eutherians and consists of more than 50 highly conserved genes in humans. A …
-
Apoptosis Determinants in Drosophila Melanogaster
The file named "chewsu.pdf" is the primary dissertation file. All other files ("*.mov") are supplemental files and may be viewed individually.
-
Transcriptional Regulation of Neonatal Heart Regeneration and Direct Cardiac Reprogramming
… adult mammalian heart has limited capacity for regeneration following injury, whereas the neonatal heart can readily regenerate within a short period after birth. Deciphering the molecular underpinnings of neonatal heart regeneration and the blockade to regeneration in later life may provide novel …
-
β-Globin Enhancers Regulate Bistable Gene Expression States
… enhancers can coordinately regulate a target gene to ensure robust expression. Under the failure rate model, each redundant enhancer contributes a probability of target gene expression in the cell, and genetic deletion will cause single-cell expression phenotypes. However, this model has been …
-
GATA Like Protein-1: A Somatic Cell Factor Required for Normal Ovarian Development and Function
Oogenesis and follicular maturation are processes that require organized and precisely timed communication through paracrine and endocrine signals of neighboring tissues. Deviations in the cross talk between ovarian cells, or aberrant gene expression within one of the cell populations, can lead to …
-
Nuclear Receptors in Lung Cancer
… and therapeutic information by studying of the expression of the nuclear receptor (NR) superfamily in lung cancer. Using quantitative real-time PCR, mRNA expression levels for the 48 members of the NR superfamily were profiled in 56 lung cell lines. Based on the resulting dataset, further …
-
Multifunctional Regulators of Cardiac Disease and Development
Embryogenesis requires delicate regulatory mechanisms. A single cell embryo divides into millions of daughter cells to form an organism comprised of various organs with different shapes and function. Organogenesis is mainly controlled by genes that are expressed in a tissue-specific manner. Thus, …
-
Epigenetic Regulation of Oligodendrocyte Development and Regeneration in the Central Nervous System
… requires precise coordination between epigenetic programming and transcriptional regulation. In this thesis, I present my findings on two epigenetic regulatory complexes Chd7/Sox10 and lncOL1/Suz12 in CNS myelination and remyelination. First, we show that chromatin remodeler Chd7 is …
-
Genome-Wide Analysis of Transcription Factors Ascl1 and Ptf1a in Development and Cancer
… factors to regulate tissue specific gene programs. Many of the same transcription factors can be found in multiple tissue types and are crucial for their development, and at other times these same factors can be misused in disease states. The basic helix-loop-helix (bHLH) factors …
-
Compensation Between Foxp Transcription Factors Maintains Proper Striatal Function
… factors expressed in SPNs can result in neurodevelopmental disorders (NDDs). Paralogous transcription factors Foxp1 and Foxp2, which are both expressed in the dopamine receptor 1 (D1) expressing SPNs, are known to have variants implicated in NDDs. Paralogous transcription factors are thought …
-
Post-Transcriptional Regulation of Maternal mRNA Shapes Early C. Elegans Embryogenesis
Much of early embryogenesis is controlled through complex networks comprised of maternally provided factors. Oocytes are packed with protein and RNA that are ready to spring into action after fertilization to guide early embryonic development. The regulation of maternally provided factors is …
-
Investigating the Transcriptional Regulation of PTF1A and the Function of PRDM13 to Specify Dorsal Spinal Interneurons
Transcriptional regulation is a fundamental process required for cell fate specification. During neural development, complex interactions of diverse transcription activators and repressors regulate lineage specific programs. The multitudes of neuronal subtypes generated during development is …
-
Investigating the Function of an Actin Nucleation-Promoting Factor N-WASP in Mammalian Myoblast Fusion
Pages 61-89 are misnumbered as pages 75-103, and pages 90-100 are misnumbered as pages 102-112.
-
Developmental Regulation of the Murine CD4 Gene
… the molecular mechanism for the control of CD4 expression during T cell development had not been determined, it is the focus of this dissertation. A series of recombinant DNA constructs were made to determine the contribution of putative transcriptional control elements in regard to CD4 …
-
Modulation of Transcription Factor Chromatin Association and Gene Transcription Program in Embryonic Stem Cell and Triple Negative Breast Cancer by Poly (ADP-Ribose) Polymerase 1
Pages ix-xvi are incorrectly numbered as pages xiv-xxi.
-
Identification and Characterization of Control Elements within the Murine CD4 Gene
<p>The control of CD4 gene expression is essential for T lymphocyte development. Since the molecular mechanism for the control of CD4 gene expression during T cell development had not been elucidated, a study of the factors that control CD4 gene expression may lead to further. Toward these goals, …
-
Molecular Dissection of Hand2 During the Formation of Pacemaker-Like Myocytes During Direct Reprogramming
Pages v-vi are misnumbered as pages vii-viii.
Page 1 of 2