Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 15232 for “"Gene"”.
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Bayesian Statistical Methods In Gene-Environment and Gene-Gene Interaction Studies
… diseases such as cancer result from multiple genetic changes and environmental exposures. Due to the rapid development of genotyping and sequencing technologies, we are now able to more accurately assess causal effects of many genetic and environmental factors. Genome-wide association studies …
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Characterization of Gene-by-Age Interaction and Gene-by-Gene Interaction In Coronary Artery Disease
… impact of age on coronary artery disease (CAD). Gene-by-age (GxAGE) interactions were tested at genome-wide scale, along with genes' marginal effects in age-stratified groups. Based on the interaction model, age plays the role as a modifier of the age-CAD relationship. SNPs associated with CAD in …
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Reconstructing gene function and gene regulatory networks in prokaryotes
… a complex environment lies with the network of genetic interactions that process information regarding the state of the cell and its local environment. The object of this study has been to better understand bacterial genetic regulatory networks, which conceptually consist of nodes (the genes) …
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Improving Viral Vectors for Gene Targeting in Gene Therapy
… one out of every hundred live births (WHO). Gene targeting is a term that is used describe the manipulation of genetic material, either by adding a gene in a specific locus, creating a mutation at a specific locus, or correcting a gene at a specific locus. Here, unless otherwise noted, we …
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Gene discovery in Catharanthus roseus using virus induced gene silencing
This thesis presents the use of Virus Induced Gene Silencing (VIGS) for the discovery of enzymes and transporters involved in monoterpene indole alkaloid (MIA) metabolism in the medicinal plant Catharanthus roseus. C. roseus is the source of a number of MIAs that are used as chemotherapeutic agents …
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Archaeal Gene Identification
… unique nor copious elements of the archaeal gene complement. In their stead were numerous proteins with no identified function and a significant literature describing biochemical reactions and phenotypes yet to be associated with genes. This thesis reports on several different projects, each …
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Microfluidic gene synthesis
… is highly desired by researchers, as synthetic genes and longer DNA constructs are enabling to numerous powerful applications in both traditional molecular biology and the emerging field of synthetic biology, from the synthesis of large sets of novel proteins to the complete re-writing of …
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Viral HSV1-TK gene, radiolabeled FIAU, and ganciclovir: combined gene targeted radiotherapy and suicide gene therapy for prostate cancer
The strategy of suicide gene therapy in cancer is based on the idea of enabling tumour cells, by gene transfer, to convert a non-toxic pro-drug into a toxic product. Previous work has shown that the combination of herpes simplex virus type 1 thymidine kinase gene (HSV1-tk) transfer with the …
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Functional gene analysis in cultured vertebrate cells using siRNA mediated gene silencing
Die Expression von Genen kann sequenzspezifisch durch small interfering RNAs (engl. kleine interferierende RNAs, siRNAs) in einem als RNA Interferenz (RNAi) bezeichneten Prozeß herunterreguliert werden. Die Anwendung von RNAi Technologie erlaubt die systematische Analyse von Genexpression und …
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Characterisation of a protease-dependent gene regulation system for gene therapy applications
Gene therapy is a promising approach for the treatment of a wide range of chronic diseases. These therapies typically utilise strong, constitutively active promoters to drive high levels of recombinant protein expression. Unregulated gene expression is a key issue limiting clinical translation of …
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Light-activated gene expression
A method for activating gene expression in cells by using photo-caged small molecules was developed. This method uses the Nuclear Hormone Receptor (NHR) family as a model system. This tool provided an opportunity to study the spatial and temporal control of genes by using small synthetic molecules …
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Gene polymorphisms in SLE
… (SLE) is an autoimmune disease, with a strong genetic component. It is characterised by hyperactive T and B cells, chronic inflammation and the production of antinuclear autoantibodies. SLE affects mostly women of child baring age, with a 9:1 ratio, women to men and has been reported to be more …
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TrkB and gene expression
… in understanding how neurotrophins regulate gene expression and, in particular, how BDNF does this through its high affinity receptor TrkB during neurogenesis. In order to answer this question, I planned to adopt the following approaches. First, to analyze global changes in gene expression …
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Gene misexpression in humans
Gene misexpression is the unexpected transcription of a gene in a context where it is usually inactive. In humans, gene misexpression has been implicated in cancers and several rare diseases, for example congenital limb malformations, congenital hyperinsulinism and monogenic severe childhood …
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Gene expression array simulator
Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, June 2002.
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Synthesising executable gene regulatory networks in haematopoiesis from single-cell gene expression data
… in biology is to understand the complex gene regulatory networks which control tissue development in the mammalian embryo, and maintain homoeostasis in the adult. The cell fate decisions underlying these processes are ultimately made at the level of individual cells. Recent experimental …
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Using co-expression to redefine functional gene sets for gene set enrichment analysis
Manually curated gene sets related to a biological function often contain genes that are not tightly co-regulated transcriptionally. which obscures the evidence of coordinated differential expression of these gene sets in relevant experiments. To address this problem, we explored strategies to …
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Gene-supplemented collagen scaffolds for non-viral gene delivery for brain tissue engineering
… vehicle with therapeutic molecules, cells and/or genes has yielded promising results for brain injury repair. The purpose of this thesis was to develop a collagen scaffold for the non-viral delivery of the gene encoding for Glial Cell-Derived Neurotrophic Factor (GDNF); hence to provide a local, …
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