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Showing 1 to 5 of 5 for “"Gelucire"”.
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Design and evaluation of hot melt extruded transdermal patches.
… methylcellulose, Xantural®75, Pluronic® F127, Gelucire 44/14) and hydration influence. Gelucire 44/14 containing formulations emerged as the most satisfactory systems which improved in vitro drug permeation profiles significantly by means of hydration. Intriguing structural changes upon …
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Development and physical characterisation of polyethylene glycol glycerides-based gel formulations for macromolecule delivery
… the bioavailability of protein/peptides. Gelucire 50/13 is a complex mixture of glycerides and PEG. It is mainly used in solid oral formulations for delivering small molecular weight drugs. The purpose of this project was to develop novel uses of Gelucire as a liquid crystalline-based …
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Preparation and Evaluation of Cefuroxime Axetil Gastro-Retentive Floating Drug Delivery System for Improved Delivery via Hot-Melt Extrusion Technology
… CA was highly soluble in Kolliphor® TPGS and Gelucire® 44/14, and solubility increased linearly as the concentration increased. All the extruded granules shofloating lag time of less than 5 seconds and floated for more than 12 h simulated gastric fluid. Optimized formulation was able to give a …
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Drug-Polymer and Drug-Lipid Miscibility for the Development of Amorphous Solid Dispersions and Solid Lipid Nanoparticles
… (glyceryl dibehenate, COM) were prepared with Gelucire (GEL) 44/14 or 50/13 as surfactant at 5:2 w/w (lipid:surfactant) and 2:1 w/w (FLT:lipids/surfactants). Miscibility of lipid and surfactant mixtures with and without FLT were investigated using MDSC. SLNs with and without drug-loading were …
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Characterisation of cysteamine prodrugs for the treatment of cystinosis and evaluation of liquid fill technology.
Cystinosis is a rare, autosomal, recessive disease characterised by raised levels of the amino acid cystine in the cells of most organs in the body which can cause organ damage. The treatment involves the oral administration of the aminothiol, cysteamine (Cystagon(TM)), but this has an offensive …