Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"Gcn5"”.
-
Characterization of the ADA/GCN5 transcriptional adaptor complex
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
-
Gcn5 Loss Impacts Myc-Driven Cancer In Mice and Human Cells
<p>GCN5 is the catalytic subunit in the acetyltransferase module of SAGA and ATAC, multiprotein complexes involved in the modification of histone and nonhistone proteins. GCN5 is most recognized as a co-activator of gene transcription. The SAGA complex is recruited to chromatin by transcription …
-
Isolation of GCN5 and ADA5 in a selection for transcriptional adaptors
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
-
Role of The Gcn5 Histone Acetyltransferase In Spinocerebellar Ataxia Type 7 and In Immature Neurons
… the effects of polyQ-ATXN7 on the activity of Gcn5, the HAT catalytic subunit of SAGA. Here I showed that reducing Gcn5 expression accelerates both cerebellar and retinal degeneration in a mouse model of SCA7. Deletion of Gcn5 in Purkinje cells in mice expressing wild type Atxn7, however, …
-
Understanding C/EBPbeta LAP/LIP Transcriptional and Adipogenic Potential Through Regulation by HDAC1 and GCN5
… manner. For instance, the acetyltransferases GCN5/PCAF and the deacetylase complex mSin3A/HDAC1 regulate C/EBPβ activity on the C/EBPa promoter. GCN5/PCAF-mediated acetylation of C/EBPβ was shown to positively affect its transcriptional activity in a steroid-dependent mechanism via the …
-
Gcn5 Impacts Fgf Signaling At Multiple Levels and Activates C-Myc Target Genes During Early Differentiation of Embryoid Bodies
… that proceed gastrulation, and report that GCN5, a histone acetyltransferase (HAT) essential for embryonic development, is required for proper expression of multiple genes encoding components of the FGF signaling pathway, and for normal activation of ERK and p38 downstream of FGF signaling …
-
Post-Translational Modifications of the Paired Box Transcription Factor 7 (Pax7) in Satellite Cells During the Repair of Injured Skeletal Muscle
… of amino acid synthesis protein 5-like 2 (GCN5), an acetyltransferase, is known to work in conjunction with Sirt1 modulating PGC-1&agr; in hepatic gluconeogenesis. With this information, it is logical to test if GCN5 also works with Sirt1 in the satellite cell response to muscle injury. The …
-
Lysine acetyltransferase Gcn5-B regulates the expression of crucial genes in Toxoplasma and its function is regulated through lysine acetylation
… is unusual among invertebrates in possessing two GCN5-family lysine acetyltransferases (KATs). While GCN5a is required for gene expression in response to alkaline stress, this KAT is dispensable for parasite proliferation in normal culture conditions. In contrast, GCN5b cannot be disrupted, …
-
Histone modifications and the Arabidopsis thaliana circadian clock
… movement and delayed fluorescence (DF) rhythms. GCN5/ HAG1 mutant plants (gcn5) exhibited erratic TOC1 expression in both constant dark (DD) and constant light (LL) conditions. Although TOC1 expression appeared to be rhythmic in both DD and LL conditions, the waveform of the rhythm was altered in …
-
Regulation of Mitochondrial Function by Histone Acetylation and Mitochondrial Acetyl-CoA Levels in Saccharomyces cerevisiae
… chaperone reporters, in a manner dependent on Gcn5, a histone acetyltransferase (HAT). Subsequent genetic and transcriptome analyses indicated that Gcn5 functions in the HAT module of the SAGA complex to regulate mitochondrial function and respiratory growth by promoting the TCA cycle, the …
-
The Novel Regulation of Histone Modification In Cancer Development
… recruits histone acetyltransferase (HAT) GCN5 for subsequent H3 acetylation. Genome-wide analysis of chromatin immunoprecipitation followed by sequencing (ChIP-seq) data sets reveals that NEDD4 regulates glucose-induced H3K9 acetylation at transcription starting site (TSS) and enhancer …
-
CRISPR-based Transcriptional Activators for Dissecting Human Gene-Regulatory Mechanisms
… activator toolbox to incorporate human CBP and GCN5 and tested their efficacy as transcriptional activators. For the optimization of the dCas9-toolbox, we showed that affinity-purification-mass spectrometry could be applied to identify the antagonistic gene for these dCas9-based tools in the …
-
Genome-wide analysis of transcription factors and chromatin in S. cerevisiae
… Taf17), and the SAGA histone-modifying complex (Gcn5, Taf17) were found not to be required for the transcription of all yeast genes but for distinct subsets of genes, revealing a surprising level of gene-specific regulation by the general transcription apparatus. The packaging of histones and DNA …
-
Chromatinstruktur und Regulation der Genexpression am Histidin/Adenin-Verzweigungspunkt in Hefe und Aspergillus
… Aktivität, die Nukleosomen GCN5-abhängig azetyliert. Darüberhinaus stellt ein Nukleosom, das sich direkt stromaufwärts des HIS7-Promotors befindet, eine Grenze zum vorhergehenden ARO4-Gen dar. Möglicherweise dient es dem Schutz vor transkriptioneller Interferenz zwischen …
-
The Role of E2F1 In The Response to Dna Double Strand Breaks
… foci formation of the histone acetyltransferase GCN5 in response to DNA double-strand breaks. E2F1 is phosphorylated at serine 31 (serine 29 in mouse) by the ATM kinase as part of the DNA damage response. To investigate the importance of this event, our lab developed an E2F1 serine 29 mutant …
-
Resolving the Role of POU1F1 in Human Growth Hormone Locus Activation
… Brg1 and with the histone acetyltransferase GCN5. These observations provide the first direct evidence for HSI POU1F1-mediated cofactor recruitment in the distal activation of hGH-N by a chromatin-modification mechanism. Finally, an inducible POU1F1-expression system was developed in …
-
Transcriptional Regulation Mediated by Human Papillomavirus E2 Protein
… with SWI/SNF chromatin remodeling complex, GCN5 histone acetyltransferase, and components of TFIID. These results indicate that full-length E2 may function as a transcriptional activator not only by directly recruiting components of the general transcription machinery to the promoter, but …
-
Transcriptional Regulatory Mechanisms of Ribosomal Protein Genes
… recruitment of TBP is dependent on SAGA (Spt-Ada-Gcn5-acetyltransferase). Like ribosomal protein genes, antisense transcription is also enhanced by TAFs. However, it remains unknown whether NuA4 also promotes TAF-regulated antisense transcription. The results illustrate that like ribosomal protein …
-
HISTONE POSTTRANSLATIONAL MODIFICATIONS AND GENE EXPRESSION IN SACCHAROMYCES CEREVISIAE
… is a bona fide subunit of SAGA (Spt3-Ada-Gcn5 acetyltransferase) co-activator complex and selectively regulates both di and trimethylation of histone H3K4 at the core promoter of a SAGA-dependent gene in vivo. However, over the open reading frames for a subset of constitutive genes H2B …
Page 1 of 2