Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Gating mechanism"”.
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Voltage-Gating Mechanism in Potassium Channels
… investigate the ion permeation, as well as the gating mechanism of voltage-gated potassium channels. The atomic-resolution structures of Kv1.2 in the active and resting state conformations are refined in an explicit representation of the membrane environment. The gating charge of the Kv1.2 …
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Voltage-Gating Mechanism in Potassium Channels
… investigate the ion permeation, as well as the gating mechanism of voltage-gated potassium channels. The atomic- resolution structures of Kv1.2 in the active and resting state conformations are refined in an explicit representation of the membrane environment. The gating charge of the Kv1.2 …
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Molecular Dynamics Studies of the *Gating Mechanism of a Mechanosensitive Channel
… of the sequence of motions involved in MscL gating, suggested the likely form of the open state, and identified residues crucial in setting MscL's tension threshold. The gating process was investigated through simulations of the bare protein under conditions of constant surface tension. Under …
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Molecular Dynamics Studies Of The Gating Mechanism Of A Mechanosensitive Channel
Submitted by Meng Tao (mengtao2@illinois.edu) on 2012-10-12T23:59:36Z No. of bitstreams: 1 Gullingsrud.pdf: 9847446 bytes, checksum: d830d33e4dfe17fd16751f5656ebd512 (MD5)
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Modulation of The Receptor Gating Mechanism and Allosteric Communication In Ionotropic Glutamate Receptors
… nature, large size of the protein, complex gating mechanism and inadequate knowledge regarding the conformational dynamics of the receptors during channel gating mechanism have been some of the limiting factors in elucidating the structure-function relation of iGluRs. Thus, to understand the …
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Gates and Latches: the mechanochemistry of ATP binding in kinesin 1 and Eg5
… along microtubule filaments by Kinesin 1. A gating mechanism is needed to coordinate ATP binding to the two catalytic domains within Kinesin 1 in order to prevent simultaneous binding, hydrolysis and detachment of both heads which could prematurely terminate cargo transport. The second system …
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Auditory Neurons in the Dorsal Cortex of the Inferior Colliculus: Responses to Contralateral Tone Bursts and Modulations by the Auditory Cortex
… My results suggest that the ICd may provide a gating mechanism that helps the auditory system to selectively process novel sounds in the acoustic environment.
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Mild Traumatic Brain Injuries and Their Implications on Changes in Event Related Potentials: A look into Visual Gating (P50)
… potentials (ERPs) associated with sensory gating and how this cognitive property is affected in those who have a self-reported concussion. Here we show that a visual attention and gating mechanism exists in both populations (control and concussed) as seen by the P50 ERP after the …
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Gated Transformer-Based Architecture for Automatic Modulation Classification
… incorporating a multi-head self-attention mechanism. We train our architecture extensively across a diverse range of signal-to-noise ratios (SNRs) from the RadioML 2018.01A dataset. We introduce a novel transformer-based architecture with a gated mechanism, designed as a runtime …
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Recurrent Neural Network Language Generation for Dialogue Systems
… Network (RNN)-based surface realiser and a gating mechanism applied to input semantics. The model is motivated by the Long-Short Term Memory (LSTM) network. The RNN-based surface realiser and gating mechanism use a neural network to learn end-to-end language generation decisions from input …
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New gating states of Cystic Fibrosis transmembrane conductance regulator discovered via studying pathogenic mutations, pharmacological reagents and ATP analogs.
… I applied patch-clamp technique to explore the gating function of CFTR. Specifically, in my thesis, we approached a more complete CFTR gating scheme through three different ways. First, we proposed two new states need to be added to the original gating scheme to address unexpected results …
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Ion current modulation in bio-mimetic channel systems
… ionic current modulation by removable peptide gating in nanopore (FraC), which has the application in biomedical engineering fields such as recognition amino acid sequence and analysis of amino acids and their post-translational modifications for therapeutic purposes. The all-atom simulation …
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Invasive and Noninvasive Brain Stimulation Strategies for the Treatment of Tinnitus
… colliculus, revealing at least one potential mechanism for gating relevant versus irrelevant sound inputs. Targeting this gating mechanism could provide a neuromodulation treatment for tinnitus and/or hyperacusis which are associated with hyperactivity across auditory centers. Finally, we …
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Molecular Mechanisms of Gating, Selectivity, and Transport in Membrane Channels and Carriers
… the substrate selectivity, gas permeability and gating mechanism of AQPs, as well as the substrate binding and induced translocation in AAC, are investigated. Two AQPs from the same organism with different functionalities are used to identify key structural features determining the substrate …
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Speech enhancement using multisensory cooperative computing
… contextually salient signals via a dendritic gating mechanism. Implemented on Xilinx Ultra- Scale+ MPSoC hardware, the system achieves substantial energy savings, up to 62% in semi-supervised settings and 1250× fewer energy demands per feedforward in supervised modes, by suppressing redundant …
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Interaction of a helical peptide with membrane: Study of alamethicin
… lysis of membrane. It also suggests a possible gating mechanism for alamethicin ion channels.
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Understanding the Atomic-Scale Mechanisms of the Human [alpha]4[beta]2 Nicotinic Acetylcholine Receptor
… to understand the basic principles underlying gating, subunit assembly, ligand recognition and ion selectivity of the human α4β2 nicotinic acetylcholine receptor. I developed multiple biochemical and biophysical methods that enabled the crystallization of the α4β2 receptor. The expression …
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Regulatory and Gating Mechanisms of TMEM16A Chloride Channel
… in current desensitization or rundown, the mechanism of which is unclear. In addition, recent structural studies of TMEM16 scramblases revealed yet another Ca2+ binding site in TM2 and TM10 whose functional relevance remains unknown. By combining electrophysiology, systematic mutagenesis and …
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Identification of novel gating mechanisms underlying pharmacological potentiation of NMDA receptors
… in a subtype-selective manner. We assessed the gating mechanism of PS modulation of GluN1/GluN2A receptors transiently expressed in HEK 293 cells using whole-cell and single-channel electrophysiology. Only a modest effect on the whole-cell responses was observed by PS in dialyzed …
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