Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Gata3"”.
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The Role of Gata3 in Blood Stem Cell Emergence
… endothelium. Recently, it was reported that Gata3 plays a dual role in the development of sympathetic nervous system and haematopoietic system. In fact, Gata3 has proven to be crucial for the production of HSCs through regulation of catecholamine production from the co-developing sympathetic …
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Genomic Approaches for Pathway Identification in Regenerating Sensory Epithelia of the Inner Ear
… approaches to identify downstream targets of GATA3 in the avian utricle. The zinc finger transcription factor GATA3 is required for inner ear development and mutations cause sensory neural deafness in humans. In a previous study we had observed that GATA3 is expressed throughout the SE in the …
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THE ROLE OF THE IL4/13 PATHWAY IN THE GENETICS OF ASTHMA SEVERITY
… critical Th2 regulator GATA-binding protein 3 (GATA3) and other Th2 genes for association with baseline lung function, allergic symptoms, and health care utilization in non-Hispanic whites (n=437) and African-American (n=208) asthma patients in the Severe Asthma Research Program (SARP). Linear …
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Characterising the role of TET2 in oestrogen receptor positive breast cancer
… other proteins to regulate gene expression. GATA3 is a transcription factor that has been closely linked to ER function, although its precise contribution to ER biology is not fully understood. The initial aim of this thesis was to further investigate the role of GATA3 in ER signalling. In …
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Type I Interferon Mediates Th2 Reprogramming and Acute Suppression of Effector Functions
… function. The Th2 master transcription factor GATA3, promotes its own expression through a positive regulatory loop, uncoupling the cell from the requirement of IL-4 signaling. IFN-α/β inhibits this process by inducing epigenetic modifications within the GATA3 locus that prevent this positive …
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Dissecting the role of cathepsin V in breast cancer
… and its activities. Importantly, FoxA1 and GATA3, the crucial pioneer factors of ERα transcription, were also altered in cathepsin V depleted cells; therefore, it is plausible that cathepsin V may regulate ERα expression by mediating the expression of FoxA1 and GATA3. While the molecular …
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Ctla-4 transcriptional activation: regulation of induced expression
… T cells. The Th2 associated transcription factor GATA3 is both elevated and activated by phosphorylation after treatment with the proteasome inhibitor bortezomib, which in turn leads to CTLA-4 transcriptional activation in primary CD4 T cells. This finding may in part explain the increase in …
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Bmp-Signaling Regulates A Common Transcriptional Program to Control Facial Form and Skeletal Morphogenesis
… <em>Hand1, Gadd45</em><em>g</em> and <em>Gata3</em> that was bound by Smad1/5 in the developing mandible revealing direct, Smad-mediated regulation. These data indicate that Bmp-signaling regulates craniofacial skeletal development and facial form by balancing self-renewal and …
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Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
… define a key function for Bcl6 in repressing Gata3 function and miR-21 expression in Tregs, and provide greater understanding of the control of Th2 inflammatory responses by Treg cells.
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Transcriptional Regulation of T Helper Cell Differentiation in Autoimmunity
… production, and a reciprocal increase in GATA3 expression. We also observed a decrease in IL-23R expression both ex-vivo in splenocytes from siRNA T-bet treated mice and when cells were transfected with siRNA T-bet and subsequently activated in vitro. When T-bet was silenced we observed an …
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Identification of novel regulators of lymphocyte development and differentiation using CRISPR-Cas9 screens
… factor reporter mice (including Id2, T-bet, Gata3 and RORγt mice) identified additional potential novel regulators of the ILC developmental network. The application of functional CRISPR-Cas9 screens in primary immune cells has successfully identified new regulators of lymphocyte development …
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Investigation of neuron T cell interaction in central nervous system tuberculosis
… neurons induced expression of Tbet, RorγT and Gata3 T cell transcription factors through direct contact with T cells. These data highlighted the likelihood of neurons activating T cells upon mycobacterial stimulations. It may potentially be utilised to broaden the understanding of CNS immunity …
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Role of Notch Signaling in T Cell Polarization
… assays support that T-bet and ROR-γt, but not GATA3 are direct targets of Notch1 under Th17 differentiating conditions.</p><p>A role of Notch signaling in T cell differentiation is further validated using Experimental Autoimmune Encephalomyelitis (EAE) model in collaboration with Dr Barbara …
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Gene expression analysis in breast cancer
… specimens identified FOXA1, SPDEF, C1ORF34 and GATA3 expression to be highly correlated. Three sub-clusters were identified among the ER-negative cluster. One represented ERBB2 over-expressing cluster. Additionally two unique groups of patients, with significant differences in survival, …
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Determining the Signalling Pathways that Govern Human Naive Pluripotency
… signalling suppresses expression of GATA2 and GATA3 and upregulates KLF4 transcripts. Finally, I investigate whether ablation of PKCι is sufficient to replace the activity of the PKC inhibitor, Gö6983. Established naïve cultures that are PKCι null continue to express naïve markers and suppress …
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An integrated network of estrogen receptors alpha and beta, and coregulators, for deciphering estrogen signaling in breast cancer cells
… in which the actions of cofactors such as FOXA1, GATA3, and E2F enforce the selectivity and range of ERα and ERβ binding and gene regulatory actions, with the coregulators SRC3 and RIP140 preferentially supporting the stimulatory actions of both receptors on gene expression.
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Insights into Neuroblastoma Initiation and Disease Progression Through integrative Genomics and Epigenomics
… the newly evolved protective TATA allele ablates GATA3 binding and enhancer activity, and is associated with decreased total and allele-specific LMO1 expression in neuroblastoma primary tumors. These findings indicate that a recently evolved polymorphism within a super-enhancer element in the …
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Dietary Supplementation of Omega-3 Fatty Acids Influences the Equine Maternal Uterine Environment and Embryonic Development
… markers of endoderm differentiation, along with GATA3 and ELF3, markers of trophectoderm differentiation were greater (P< 0.05) in embryos from LCPUFA supplemented mares (n=5), than controls (n=5). These results indicate that algae-derived LCPUFA supplementation during the peri-conceptual period …
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Accurate Mutation Annotation and Functional Prediction Enhance The Applicability of -Omics Data In Precision Medicine
… deletion, <em>NR1H2</em> R175 insertion, and <em>GATA3</em> P409 insertion with different functional associations. Our study addresses a long-term challenge of explicitly distinguishing driver mutations from passengers, and nominates a set of putative driver mutations that possess diverse …
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