Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 378 for “"Gastrointestinal tract"”.
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Nitric oxide in the rat gastrointestinal tract
… and the role of nitric oxide (NO) in the rat gastrointestinal tract. The major objectives were (i) to characterise NOS isoforms in the gastric glandular mucosa, (ii) to localise NOS isoforms in the rat gastric glandular mucosa, (iii) to investigate the role of NO in carbachol-stimulated …
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Optical diagnostics for oral and gastrointestinal tract pathologies
Oral potentially malignant disorders (OPMD) are a significant global health burden. They are a precursor to oral cancer and indicate a tissue with a higher risk of developing a malignancy. Early diagnosis can improve patient outcomes by minimally invasive treatment, reduced mortality rate and …
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The effects of metformin on the gastrointestinal tract
… formulations. These studies suggest that the gastrointestinal tract may also be an important site of metformin action. In this thesis, 2D monolayer cultures generated from intestinal organoids were used to investigate the mechanisms of metformin action in intestinal cells. Bulk RNA-sequencing …
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Real-Time Radiation Detection within the Gastrointestinal Tract
… describes radiation monitoring internal to the gastrointestinal tract, which could provide a means of alerting the individual to their surroundings or trigger a drug delivery response. Internal radiation monitoring also has benefits in radiation therapy applications where injury to the …
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Sodium sensitive sites in the gastrointestinal tract stimulate natriuresis
… a sensor may be located somewhere along the gastrointestinal tract. The gastrointestinal tract is an ideal location for a sodium sensor to alert the body to impending changes in plasma sodium concentration. A gastrointestinal sodium sensor capable of monitoring ingested sodium loads and …
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Studies on Glutathione Peroxidase of the Rat Gastrointestinal Tract
Made available in DSpace on 2015-05-12T22:36:30Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7514151.PDF: 2915447 bytes, checksum: 37da301df0cbf65b459a4f500e74f16c (MD5) Previous issue date: 1975
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Ingestible capsules for therapeutic injections in the gastrointestinal tract
… rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limits their administration to parenteral routes. An oral biologic delivery system must aid in both localization and permeation to achieve systemic drug uptake. In this thesis I will describe two oral capsules …
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Environmental signals that control T lymphocytes in the gastrointestinal tract
The Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) binds the Aryl Hydrocarbon Receptor (AHR) and also the Hypoxia Inducible Factor-1α (HIF-1α). Both the AHR and HIF-1α are key sensors of the microenvironment. Dietary tryptophan metabolites and microbiota catabolites are AHR ligands and …
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Delivery of macromolecule therapeutics via jetting in the gastrointestinal tract
… an empirical evaluation of jet interaction with gastrointestinal tissues, a millimeter-scale jetting device capable of autonomous drug delivery, and in-vivo studies in which the tested devices elicit substantial drops in blood glucose levels via the delivery of insulin across the gastric mucosa.
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Studies of the purine biosynthetic pathways in the gastrointestinal tract.
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Nutrition and Food Science, 1979.
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Investigation of mechanisms underpinning host-microbial interactions in the gastrointestinal tract
… host-bacterial interactions in both the gastrointestinal tract and in extra-intestinal tissues. In the first study (Chapter II) we identified the relative contributions of different pattern recognition receptors to the triggering of macrophage cytokine responses by the widely studied …
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Ultrastructure and function of the gastrointestinal tract in marine herbivorous fishes
The structure of the gastrointestinal tract (GIT) of temperate and tropical marine herbivorous fishes was described using histological and ultrastructural approaches. Radial distribution of endosymbiotic microbiota in the hindgut, and the association of microbiota with degradation of algal …
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Ecology of Lactobacillus in the gastrointestinal tract of the weanling piglet
… ecology of adherent Lactobacillus species in the gastrointestinal tract sixteen piglets were used. At 28 d of age four pigs were killed and served as the pre-weaning control (PW). Four pigs remained on the sow (Sow), four pigs were fed a corn-soy-lactose (CSL) diet and the remaining four pigs were …
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Endoscopic optical coherence tomography for clinical studies in the gastrointestinal tract
… OCT suitable for clinical research in the human gastrointestinal (GI) tract. Endoscopic OCT imaging is challenging because fast and stable optical scanning must be implemented inside a small imaging probe to acquire useable volumetric information from internal human bodies. Although several …
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Modeling Sporadic Tumor Formation Driven By Telomere Dysfunction In The Gastrointestinal Tract
… a mouse model of telomere ysfunction in the gastrointestinal tract through the conditional deletion of Pot1a that recapitulates the microscopic features seen in severe telomere attrition. Combined intestinal loss of Pot1a and p53 lead to formation of invasive adenocarcinomas in the small and …
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Nutritional strategies to control clostridium perfringens in gastrointestinal tract of broiler chickens
A series of experiments were conducted to examine the effect of chemical composition of the diet on intestinal Clostridium perfringens populations and necrotic enteritis (NE) in broiler chickens. In the first experiment, birds were fed high concentrations of dietary protein (fish meal or soy …
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