Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Gastrointestinal Microbiome"”.
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Soy isoflavones and swine health
… an indirect route such as alteration of the gastrointestinal microbiome. For that reason, a third experiment was conducted to evaluate how the ingestion of soy isoflavones in the context of a PRRSV-infection affected the composition of the gastrointestinal microbiome across the entire growth …
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Unraveling the Microbiome Connection: Exploring the Nexus of Endometriosis, Anxiety, and Dysbiosis
… research suggests that alterations of the microbiome may play a key role in both endometriosis and anxiety. We hypothesized that individuals with endometriosis and co-occurring anxiety will exhibit differences in self-reported mental health symptoms, endometriosis/pelvic pain symptoms, and …
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Relationships between circadian rhythms, timing of eating behaviors, and the human gastrointestinal microbiota
… gained recent attention is the modulation of the gastrointestinal microbiota. Microbiota interventions have come into the spotlight because of the proposed relationships between the microbial community’s composition, function, and human health. One of the most common strategies for modulating the …
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Microbiome Dynamics in Broilers Infected with Infectious Bronchitis Virus and the Protective Role of Lactobacillus-Based Probiotics
… study first, we evaluated the respiratory and gastrointestinal microbiome dysbiosis at 6, 9 and 15 days post-infection (dpi) in commercial broiler chickens following challenge with IBV DMV/1639 strain. Trachea and cecal tonsils of IBV challenged group showed significantly higher …
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Immune Checkpoint Blockade Induces Gut Microbiota Translocation That Augments Extraintestinal Anti-Tumor Immunity
Gut microbiota are critical for effective immune checkpoint blockade therapy (ICT) for cancer. The mechanisms by which gut microbiota augment extraintestinal anti-cancer immune responses, however, are largely unknown. Here, we find that ICT induces the translocation of specific endogenous gut …
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Polysaccharide utilization by the human colonic bacterium, bacteroides intestinalis DSM 17393
The human gastrointestinal microbiome has co-evolved with the host for an extended period, generating an intrinsic metabolic network capable of modulating both the microbial community and host physiology. Changes in the gut environment shape the microbial community with one of the main driving …
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Colonocyte-Derived Lactate Promotes Enterobacteriaceae Fitness During Non-Infectious Colitis
… such as exchange of metabolites or resistance to gastrointestinal pathogens. In disease, however, the perturbation of these complex interactions can exacerbate pathogenesis. In this study, we examine the mechanisms promoting the disruption of normal host-microbe interactions after perturbances …
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Factors Governing Gastrointestinal Colonization of Candida albicans
Candida albicans can colonize the human gastrointestinal tract (GI) and cause disseminated infections in immunocompromised hosts. Depletion of specific gut commensal microbiota is associated with or results in increased C. albicans burden in the gut and increased likelihood of dissemination in …
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Changes in the Gut Metabolic Landscape Drive Inflammation-Associated Dysbiosis and Host Responses
The file named "HUGHES-PRIMARY-2022-1.pdf" is the primary dissertation file. Three (3) supplemental files are also available and are referenced in the dissertation file as appendices; the files are Microsoft Excel documents and may be viewed individually.
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Dysbiosis-Associated Changes in Host Metabolism Produce Lactate to Support Enterobacterial Expansion During Inflammation
The lumen of the gastrointestinal tract is heavily colonized by microbes, termed the gut microbiota. Under normal conditions, fermentative anaerobes constitute the majority of the gut microbiota. However, during inflammation there is a change in the nutritional environment of the gut that enables …
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Interplay Between Tryptophan Metabolites and the Virulence Factors of Enteric Pathogens
… have an impact on dictating the underlying gut microbiome composition. Gut bacterial populations effectively sense these molecular signatures and modulate gene expression to colonize this niche. An invading intestinal pathogen, to effectively colonize the gut, must sense and respond to the …