Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Gastro- Oesophageal Reflux"”.
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Exploring Gastro-oesophageal Reflux in Infants and Children
Background: Gastro-oesophageal reflux in babies, young children and teenagers is a frequent cause of symptoms, parental concern and paediatric referrals. Sequelae can include failure to thrive, haematemesis, and recurrent aspiration. Current conservative management includes reassurance, feeding …
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Reasonability of gastro-oesophageal reflux study requests (contrast swallows and milk scans) for the detection of gastro-oesophageal reflux disease at Red Cross War Memorial Children's Hospital - a retrospective analysis
… variety of signs that are often attributed to gastro-oesophageal reflux disease (GORD). The difficulty lies in distinguishing between physiological gastro-oesophageal reflux (GOR) and GORD and none of the tests available can, alone, give conclusive evidence for the latter. Clinicians are often …
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Pharmacological control of transient lower oesophageal sphincter relaxations / Ilmars Lidums.
… sphincter relaxations as a treatment of gastro-oesophageal reflux. Two major classes of pharmaceutical agents were explored; anticholinergic agents and the GABAb agonist, baclofen.
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The role of lipid laden macrophages in airways disease
… of the airway and is often associated with Gastro-Oesophageal Reflux (GOR). Lipid laden macrophages (LLM) in the airway have previously been reported indicative of aspiration secondary to GOR. We hypothesised that lipid droplets from undigested or partially digested food may be aspirated …
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The involvement of bacteria in the progression of Barrett’s oesophagus to adenocarcinoma of the oesophagus
Barrett's oesophagus (BO) arises from chronic gastro-oesophageal reflux disease(GORD). Patients have an increased risk of adenocarcinoma (ADC), which is the sixth most common cause of cancer mortality in the UK. All ADC develop from BO, and over the last twenty years there has been a marked …
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Investigation of liquid sodium alginates as mucoadhesive bandages coating the oesophageal mucosa and protecting it from gastric reflux
Gastro-oesophageal Reflux Disease (GORD), is generally caused by excess gastric reflux back to the oesophagus where damage to the mucosa results in injury. GORD is a very common disease in western countries, more than a quarter of western people are suffering from this disease and there is a trend …
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Triage-driven diagnosis for early detection of oesophageal cancer
… my work to advance the early detection of oesophageal adenocarcinoma by investigating translational aspects of a minimally invasive oesophageal cell sampling technology for the detection of Barrett oesophagus. Most oesophageal adenocarcinoma patients present with advanced disease, requiring …
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The oesophageal mucosa in reflux disease - endoscopic appearance and tissue structure
Gastro-oesophageal reflux disease (GORD) is very common in especially the western world. The cardinal symptoms are heartburn or regurgitations and are caused by the reflux of noxious compounds from the stomach/duodenum to the oesophagus. The first-choice diagnostic method is endoscopy with the …
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ETD: Symptoms and Intraoperative findings in patients undergoing revision fundoplication
Approximately 20% of patients who undergo anti-reflux surgery will report a recurrence of reflux symptoms or develop new symptoms, with 5% ultimately requiring revision fundoplication. The aim of this study is to document symptoms at representation, pre-operative work-up and intraoperative findings …
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Current tele-audiology services in clinical practice and the influence of the Covid-19 pandemic on audiologists? perceptions of tele-audiology
Approximately 20% of patients who undergo anti-reflux surgery will report a recurrence of reflux symptoms or develop new symptoms, with 5% ultimately requiring revision fundoplication. The aim of this study is to document symptoms at representation, pre-operative work-up and intraoperative findings …
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Understanding the molecular mechanism through which aspirated bile triggers chronic Pseudomonas aeruginosa infections in respiratory disease
… been the subject of intensive research efforts. Gastro-oesophageal reflux (GOR) has recently emerged as a major co-morbidity in CF and a range of other respiratory conditions and is associated with the presence of bile acids in the lungs of CF patients, a consequence of micro-aspiration of …
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A Comprehensive Assesment of Eosinophilic Oesophagitis
… EoE from its primary differential diagnosis, gastro-oesophageal reflux disease (GORD). The lack of a diagnostic adjunct further compounds this issue, although immunoglobulin G4 (IgG4) staining has recently shown some potential. The onset of disease has been established in both children and …
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Risk and pathogenesis of dysphagia related to antireflux surgery
… or drink, is experienced by some patients with gastro-oesophageal reflux disease and is a common adverse effect of antireflux surgery, a procedure involving diaphragmatic hiatal repair and fundoplication. Dysphagia after surgery in the absence of recognisable anatomical abnormalities is poorly …
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Aspects of paediatric gastro oesophageal scintigraphy
… foregut motility in paediatric patients; notably oesophageal transit during swallowing, gastro oesophageal reflux (GOR) and stomach emptying as measured by the gastric contents 30 and 120 minutes after deglutition of liquid. Relevant anatomy, physiology, pathophysiology and non-radioisotopic …
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Cоx-2 inhibitоrѕ in Оeѕоphаgeаl Cаncer
Introduction and Aims: The incidence of Oesophageal cancer (OC) has doubled in the last three decades and is increasing. Due to their poor outcome, strategies are being devised to prevent this disease and look into any association between pre-existing risk factors and medications which may …
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Assessment of the autonomic nervous system through the study of cardiovascular autonomic reflexes and their association with inflammation in three clinical settings.
… a. Influenza vaccination b. Reduction in oesophageal inflammation c. Reduction in weight The aim of the first study was to assess the link between inflammation resulting from the influenza vaccination and the associated changes on heart rate variability. 71 healthy volunteers opting to …
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Monitoring Tissue Function Dynamics in vitro with Bioelectronics: Towards Understanding Barrett’s Oesophagus Pathogenesis
… specialised intestinal metaplasia of the oesophageal mucosa and a precursor of oesophageal adenocarcinoma (EAC). EAC is a particularly aggressive cancer with a high mortality rate, and as such, early intervention and prevention is considered to be imperative. In order to entertain such …
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Die laparoskopische Fundoplikatio zur Therapie der gastro-ösophagealen Refluxerkrankung : eine retrospektive Studie
… an unerwünschten Nebenwirkungen und effektiver Refluxkontrolle überzeugt hat.
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Klinische und funktionelle Langzeitergebnisse nach offener chirurgischer Therapie der gastro-oesophagealen Refluxkrankheit
… Nissen fundoplication is effective therapy for gastroesophageal reflux disease. In this study, the outcomes in 115 patients treated with antireflux Surgery between 16.01.1986 - 15.12.1998 was evaluated for up to 11 Years after surgery to ascertain whether similar positive results could be …