Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Gastric Adenocarcinoma"”.
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A morphologic and immunohistochemical analysis of gastric adenocarcinoma with regard to the presence of E-cadherin and localisation of β-catenin staining
Includes abstract. Includes bibliographical references.
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Helicobacter pylori and its Association with Gastric and Oesophageal Carcinomas
… in a chronic life-long inflammation in the gastric mucosa. The aim of our studies was to investigate the association between H. pylori seropositivity and the development of gastric and oesophageal carcinomas. Nested case-control studies were performed in the Malmö Preventive Medicine cohort …
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Uncovering Signalling Pathways Mediating Gastrointestinal Morphogenesis and Tumorigenesis
… pathway, and is frequently upregulated in gastric cancer, however, its role in tumorigenesis is unclear. By investigating the function of activated-YAP, I have shown its ability to induce gastric adenocarcinoma in a cell type-specific manner. Moreover, Yap deletion in a pre-clinical model …
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Expression of interleukin-16 in gastric mucosa: a possible role in the persistance of helicobacter pylori infection
Helicobacter pylori (H. pylori) infects the human gastric mucosa of >50% of humankind and causes chronic gastritis, peptic ulcers, and gastric adenocarcinoma. H. pylori infected gastric epithelial cells (GECs) produce an array of chemokines that recruit other cells. IL-16 is potentially a key …
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A genetic screen to identify novel Helicobacter pylori virulence factors using Saccharomyces cerevisiae as a model eukaryotic cell
… and is a major etiological agent of human gastric adenocarcinoma. Of infected individuals, only 10-15% develop severe gastric disease due to environmental factors, host genetic factors, and more significantly, genetic differences in the infecting H pylori strains. Type I strains of H pylori …
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Helicobacter pylori gene regulation by virulence region located sRNAs
… to gastrointestinal diseases such as ulcers and gastric adenocarcinoma. Helicobacter pylori strains are genetically variable, and some contain a DNA region called the cytotoxin associated gene pathogenicity island (cagPAI) that encodes virulence factors. Gastrointestinal disease associated with …
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Influence of chronic Helicobacter pylori infection on systemic and neuroinflammation and its impact on cognition
… etiological agent of peptic ulcer disease and gastric adenocarcinoma. Most animal models utilized for evaluating H. pylori infection have examined the gastric effects of chronic infection with regard to ulcer and cancer development. However, interest into the potential extra-gastric influences …
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A Retrospective Review of the Technical Success of Endoscopic Stenting for Malignant Gastric Outlet Obstruction
… advanced and irresectable malignancies causing gastric outlet obstruction (GOO) with the endoscopic placement of a self-expanding metal stent (SEMS) has become standard. Internationally, technical success rates are high. This study reviewed endoscopic stent placement for malignant GOO compared …
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"Positividad coproantigénica de Helicobacter pylori en estudiantes y docentes del Instituto Nacional El Carmen, municipio El Carmen, departamento de La Unión. Año 2019"
… such as chronic gastritis, peptic ulcer and gastric adenocarcinoma; This bacterium constantly evolves in humans and is transmitted from person to person through acquisition routes such as Oral-Oral, Fecal-Oral, Gastro-Oral and by vulnerable factors such as overcrowding, raw or undercooked …
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Regulating the stabilities of NOD1 and NOD2, two innate immune receptors, with sugars and chaperones
… NOD1 mutations have been correlated with gastric adenocarcinoma and lung cancer, while three single- nucleotide polymorphisms of NOD2 have a strong correlation with Crohn’s disease. ☐ Presented in this dissertation are approaches developed to express and purify NOD1-LRR recombinantly from …
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Regulation of RUNX3 in gastric and breast cancer
… the regulation of this tumor suppressor in gastric cancer and breast cancer. Chronic infection with cagA-positive Helicobacter pylori is the strongest risk factor for the development of gastric adenocarcinoma. The cagA gene product CagA is injected into gastric epithelial cells and disturbs …
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Identification and Characterization of the Helicobacter Pylori Vacuolating Cytotoxin Receptor
Chronic infection with the gastric pathogen Helicobacter pylori is a risk factor for the development of gastric ulcer disease or gastric adenocarcinoma in humans. The success of H. pylori in the harsh stomach environment is due largely to pathogen-mediated remodeling of gastric tissue by virulence …
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Biochemistry in healthy and neoplastic human tissues: metabolic alteration revealed by HR-MAS nuclear magnetic resonance spectroscopy
… (stomach and colon) neoplasms. The human healthy gastric mucosa, and the characteristics of the biochemical profile of human gastric adenocarcinoma in comparison with that of healthy gastric mucosa were analyzed using ex vivo HR-MAS NMR. Healthy human mucosa is mainly characterized by the presence …
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An assessment of gastric cancer associated factors and strategies for early case detection in patients seen at the university teaching hospital in Lusaka, Zambia.
ABSTRACT Gastric cancer is one of the leading causes of cancer related mortality globally. It carries a very poor prognosis with a one-year survival rate of less than 15%. The main objective of this study was to investigate environmental, biological and dietary factors associated with gastric …
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An assessment of gastric cancer associated factors and strategies for early case detection in patients seen at the university teaching hospital in Lusaka, Zambia.
ABSTRACT Gastric cancer is one of the leading causes of cancer related mortality globally. It carries a very poor prognosis with a one-year survival rate of less than 15%. The main objective of this study was to investigate environmental, biological and dietary factors associated with gastric …
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Molecular characterization of a sphingomyelin binding site in the vacuolating cytotoxin of H. pylori
… in cell binding to human-derived AZ-521 gastric epithelial cells. Interestingly, a W603A mutation is also present within a vacA allele associated with a lessened propensity for gastric disease, decreased toxin binding, and differences in cell specificity. This thesis proposes a novel …