Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Gasdermins"”.
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Characterization of GSDMD as a Positive Regulator of Breast Cancer Cell Proliferation and Mammary Tumorigenesis
… and the main cause of BC-related death. The gasdermins (GSDMs) are a newly characterized gene family expressed in a wide array of human tissues and regulate many cellular roles, namely cell proliferation and cell death. The GSDMs are most famous for inducing a pro-inflammatory, lytic form of …
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OROPOUCHE VIRUS DISRUPTION OF HOST CELL FUNCTIONS: PYROPTOSIS INDUCTION AND TRANSCRIPTIONAL SUPPRESSION
… macrophages fail to activate caspases, cleave Gasdermins, or produce IL-1β upon infection. These results indicate that OROV infection triggers NLRP3-mediated IL-1β maturation and release via pyroptosis in macrophages, underscoring their potential role in OROV pathogenesis, which requires …